Mulholland or Mullholland (/mʌlˈhɒlənd/ mul-HOL-ənd) is a surname. Anglicized form of Gaelic Ó Maolchalann ‘descendant of Maolchalann’, a personal name meaning ‘chief of the calends’,

Notable people with the surname include:

• Alan Mulholland, Irish Gaelic footballer and manager
• Bob Mulholland, "senior advisor and longtime chief spokesperson" of the California Democratic Party
• Clara Mulholland (1849–1934), Irish writer
• Colm Mulholland, Irish Gaelic footballer
• Dale Mulholland, former US professional soccer player
• Danielle Mulholland, politician, Australia
• Frank Mulholland, Lord Mulholland PC KC (born 1959), Scottish judge
• Greg Mulholland, Liberal Democrat politician in the United Kingdom
• Inez Mullholland, suffragist, labor lawyer, World War I correspondent, and public speaker
• Jimmy Mulholland (born 1938), Scottish footballer
• Joe H. Mulholland, American politician
• Joan Trumpauer Mulholland, Civil Rights / integration activist
• John Mulholland (disambiguation), human name disambiguation page
• Peter Mulholland (c.1953–2021), Australian rugby league football coach
• Robert Mulholland, politician and businessman of Ontario
• Rosanne Mulholland, Brazilian actress
• St. Clair Augustine Mulholland, American Civil War colonel
• Terry Mulholland, former Major League Baseball pitcher
• Tom Mulholland (disambiguation), human name disambiguation page
• William Mulholland, civil engineer in Los Angeles circa 1900