MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:
Timed 25-Foot Walk (T25FT) - assessment of leg function by moving a short walking distance
9-Hole Peg Test (9HPT) - assessment of arm function using breadboard test
An integrated MSFC score is calculated using z-scores.[3]
Referencesedit
^ abcRudick RA, Cutter G, Reingold S (October 2002). "The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials". Multiple Sclerosis. 8 (5): 359–65. doi:10.1191/1352458502ms845oa. PMID 12356200. S2CID 31529508.
^Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi ML, et al. (November 2003). "Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite". Neurology. 61 (10): 1367–73. doi:10.1212/01.WNL.0000094315.19931.90. PMID 14638957. S2CID 17583827.
^Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T (March 2014). "Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis". BMC Neurology. 14 (1): 58. doi:10.1186/1471-2377-14-58. PMC3986942. PMID 24666846.