McEachern studied the violin at the Toronto Conservatory of Music as a boy, and played his first concert recital at Massey Hall at age 12. As a teenager Murray studied both the saxophone and clarinet, playing with Lucio Agostini and also appearing on CRBC with Percy Faith. Over time McEachern became proficient on several instruments, including the trombone, bass and trumpet.

In 1936, he went to Chicago in search of work, and got a break as soloist on trombone for Benny Goodman's big band. He also worked with the Jack Hylton orchestra and then with the Casa Loma Orchestra^[1] (led by Glen Gray) from 1937-41. In 1941, McEachern joined the Paul Whiteman orchestra^[2] and shortly after began entertaining U.S. troops during World War II. In 1947, he worked with the Phil Moore orchestra.

McEachern did studio work in his later career for Hollywood films, including solo performances in The Glenn Miller Story, Paris Blues and The Benny Goodman Story.

A successful recording artist as leader, McEachern also toured Europe in 1972 and briefly worked with the Duke Ellington orchestra in 1973 and was owner/director of the Tommy Dorsey orchestra from 1974-77. In the 1960s he was also in the Morey Amsterdam Orchestra for the Morey Amsterdam Show on Television Station KTLA in Los Angeles.

• "Murray McEachern...and friends" (Klavier)
• "Music for Sleepwalkers Only" (Key)
• "Caress" (Cap)
• "Warm Trombone" (Dot)

with Anita O'Day and Billy May:

• Anita O'Day and Billy May Swing Rodgers and Hart (Verve)

with Benny Goodman:

• "Benny Goodman Performance Recordings" (MGM)

with Phil Moore:

• "Phil Moore - Concerto For Piano And Orchestra - Concerto For Trombone And Orchestra" (Discovery)

• Murray McEachern recordings at the Discography of American Historical Recordings.