Mycobacterium obuense is a species of soil-dwelling scotochromogenic Mycobacterium.[1] The cell wall of M. obuense contains 1-tetradecanol, 2-octadecanol, and 2-eicosanol,[2] and triacylated lipoproteins.
Mycobacterium obuense | |
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Scientific classification | |
Domain: | Bacteria |
Phylum: | Actinomycetota |
Class: | Actinomycetia |
Order: | Mycobacteriales |
Family: | Mycobacteriaceae |
Genus: | Mycobacterium |
Species: | M. obuense
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Binomial name | |
Mycobacterium obuense (ex Tsukamura and Mizuno 1971) Tsukamura and Mizuno 1981
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Preparations of heat-killed Mycobacterium obuense (such as IMM-101) are immunomodulatory and have been used to direct the immune response in the treatment of cancers - notably pancreatic cancer and malignant melanoma. Recent trials have been directed towards the treatment of colorectal cancer.[3] It has been shown that human myeloid dendritic cells, (antigen-presenting cells that serve as a bridge linking the adaptive and innate immune system), can detect mycobacterial triacylated lipoproteins via TLR2 and TLR1.[4]
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