Genera within the family Myidae include:

• Cryptomya (Conrad, 1848)
  • Cryptomya californica (Conrad, 1837) – California softshell
• Indosphenia (Oliver, Hallan & Jayachandran, 2018)
  • Indosphenia kayalum (Oliver, Hallan & Jayachandran, 2018)
• Mya Linnaeus, 1758
  • Mya arenaria Linnaeus, 1758 – soft-shell clam
  • Mya baxteri Coan and Scott, 1997
  • Mya elegans (Eichwald, 1871)
  • Mya japonica Jay, 1856
  • Mya priapus (Tilesius, 1822)
  • Mya profundior Grant and Gale, 1931
  • Mya pseudoarenaria Schlesch, 1931
  • Mya truncata Linnaeus, 1758
  • Mya uzenensis Nomura and Zimbo, 1937
• Paramya Conrad, 1860
  • Paramya subovata (Conrad, 1845)
• Platyodon
  • Platyodon cancellatus (Conrad, 1837) – boring softshell
• Sphenia Turton, 1822
  • Sphenia antillensis Dall and Simpson, 1901
  • Sphenia binghami Turton, 1822
  • Sphenia luticola (Valenciennes, 1846)
  • Sphenia ovoidea Carpenter, 1864
  • Sphenia sincera Hanks and Packer, 1985
  • Sphenia tumida J. E. Lewis, 1968

• "Myidae". Integrated Taxonomic Information System.