Summary
In enzymology, a N-acylmannosamine kinase (EC 2.7.1.60) is an enzyme that catalyzes the chemical reaction
| N-acylmannosamine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 N-acetylmannosamine kinase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.60 | ||||||||
| CAS no. | 9027-53-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- ATP + N-acyl-D-mannosamine ADP + N-acyl-D-mannosamine 6-phosphate
Thus, the two substrates of this enzyme are ATP and N-acyl-D-mannosamine, whereas its two products are ADP and N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acyl-D-mannosamine 6-phosphotransferase. Other names in common use include acylmannosamine kinase (phosphorylating), acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, N-acyl-D-mannosamine kinase, N-acetylmannosamine kinase, and ATP:N-acetylmannosamine 6-phosphotransferase. This enzyme participates in aminosugars metabolism.
Structural studies edit
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AA4.
References edit
- Banerjee S, Ghosh S (1969). "Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium". Eur. J. Biochem. 8 (2): 200–6. doi:10.1111/j.1432-1033.1969.tb00515.x. PMID 4889177.
- GHOSH S, ROSEMAN S (1961). "Enzymatic phosphorylation of N-acetyl-D-mannosamine". Proc. Natl. Acad. Sci. U.S.A. 47 (7): 955–8. doi:10.1073/pnas.47.7.955. PMC 221308. PMID 13704957.
- Kundig W, Ghosh S, Roseman S (1966). "The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver". J. Biol. Chem. 241 (23): 5619–26. doi:10.1016/S0021-9258(18)96389-1. PMID 5928201.
