NCR1 Knowpia

NCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OLL, 1P6F
Identifiers
Aliases	NCR1, CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1
External IDs	OMIM: 604530 MGI: 1336212 HomoloGene: 3551 GeneCards: NCR1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,916,140 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,348,163 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; bone marrow cells; ; monocyte; ; placenta; ; liver; ; right lobe of liver; ; lymph node; ; right lung; ; upper lobe of left lung;
	Top expressed in
	blood; ; morula; ; spleen; ; right lung lobe; ; submandibular gland; ; extensor digitorum longus muscle; ; uterus; ; upper arm; ; triceps brachii muscle; ; jejunum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; SWI/SNF complex; membrane;
Biological process	cellular defense response; natural killer cell activation; signal transduction; regulation of immune response; regulation of natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	9437
	17086
ENSG00000273535; ENSG00000277629; ENSG00000273916; ENSG00000275156; ENSG00000277824;
	ENSG00000277334; ENSG00000278362; ENSG00000275637; ENSG00000274053; ENSG00000275521; ENSG00000275822; ENSG00000277442; ENSG00000189430; ENSG00000284113; ENSG00000273506; ENSG00000276450; ENSG00000278025; ENSG00000288651
	ENSMUSG00000062524
	O76036
	Q8C567
	NM_001145457; NM_001145458; NM_001242356; NM_001242357; NM_004829
	NM_010746; NM_001368364
	NP_001138929; NP_001138930; NP_001229285; NP_001229286; NP_004820
	NP_034876; NP_001355293
	Wikidata
View/Edit Human	View/Edit Mouse

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.^[5]^[6] NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.^[7]

References edit

^ ^a ^b ^c ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 GRCh38: Ensembl release 89: ENSG00000273535, ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med. 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMC 3207313. PMID 9730896.
^ "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".
^ "NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI".

Further reading edit

Biassoni R, Cantoni C, Marras D, et al. (2004). "Human natural killer cell receptors: insights into their molecular function and structure". J. Cell. Mol. Med. 7 (4): 376–87. doi:10.1111/j.1582-4934.2003.tb00240.x. PMC 6740120. PMID 14754506.
Sivori S, Vitale M, Morelli L, et al. (1997). "p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation". J. Exp. Med. 186 (7): 1129–36. doi:10.1084/jem.186.7.1129. PMC 2211712. PMID 9314561.
Vitale M, Bottino C, Sivori S, et al. (1998). "NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis". J. Exp. Med. 187 (12): 2065–72. doi:10.1084/jem.187.12.2065. PMC 2212362. PMID 9625766.
Cantoni C, Bottino C, Vitale M, et al. (1999). "NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily". J. Exp. Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
Vankayalapati R, Wizel B, Weis SE, et al. (2002). "The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium". J. Immunol. 168 (7): 3451–7. doi:10.4049/jimmunol.168.7.3451. PMID 11907104.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
Ponassi M, Cantoni C, Biassoni R, et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. doi:10.1016/j.bbrc.2003.08.007. PMID 12951052.
Foster CE, Colonna M, Sun PD (2003). "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors". J. Biol. Chem. 278 (46): 46081–6. doi:10.1074/jbc.M308491200. PMID 12960161.
Arnon TI, Achdout H, Lieberman N, et al. (2004). "The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46". Blood. 103 (2): 664–72. doi:10.1182/blood-2003-05-1716. PMID 14504081.
Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. S2CID 40345630.
Carbone E, Neri P, Mesuraca M, et al. (2005). "HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells". Blood. 105 (1): 251–8. doi:10.1182/blood-2004-04-1422. PMID 15328155.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005). "Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)". Clin. Exp. Immunol. 139 (2): 287–96. doi:10.1111/j.1365-2249.2004.02686.x. PMC 1809301. PMID 15654827.
Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
Zilka A, Landau G, Hershkovitz O, et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry. 44 (44): 14477–85. doi:10.1021/bi051241s. PMID 16262248.
Hermann E, Alonso-Vega C, Berthe A, et al. (2006). "Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells". Pediatr. Res. 60 (1): 38–43. doi:10.1203/01.pdr.0000220335.05588.ea. PMID 16690951.

External links edit

NCR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: O76036 (Natural cytotoxicity triggering receptor 1) at the PDBe-KB.

[refGRCh38Ensembl-1] ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 GRCh38: Ensembl release 89: ENSG00000273535, ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062524 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9730896-5] Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med. 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMC 3207313. PMID 9730896.

[entrez-6] "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".

[7] "NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit

External links edit