Naftifine

Summary

Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections).

Naftifine
Clinical data
Trade namesExoderil, Naftin
AHFS/Drugs.comMonograph
MedlinePlusa688020
ATC code
Identifiers
  • (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
CAS Number
  • 65472-88-0 checkY
PubChem CID
  • 47641
DrugBank
  • DB00735 checkY
ChemSpider
  • 66071 ☒N
UNII
  • 4FB1TON47A
ChEBI
  • CHEBI:7451 ☒N
ChEMBL
  • ChEMBL626 ☒N
CompTox Dashboard (EPA)
  • DTXSID6048545 Edit this at Wikidata
Chemical and physical data
FormulaC21H21N
Molar mass287.406 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Naftifine was invented at the Sandoz Research Institute in Vienna, Austria. It was the first successful antifungal medication of the allylamine class.[1]

Naftifine has triple action: antifungal, antibacterial, and anti-inflammatory. Its fungistatic activity is believed to be based on inhibition of the squalene-2,3-epoxidase enzyme, which in turn results in the shortage of ergosterol required for the formation of fungal cell membranes. With some fungal species, there is also fungicidal activity from a resulting accumulation of squalenes, leading to damage of the fungal cell membranes, including at the endoplasmatic reticulum.[1][2][3] Naftifine shows mostly fungicidal activity toward dematophytes and molds, and mostly fungistatic activity toward yeasts. It is also effective as an antibacterial agent in treating pyoderma.[citation needed]

Naftifine is almost completely metabolized in the human body, with a half-life of 2–3 days.[3] Its metabolytes do not have antifungal activity, and they are excreted with urine and feces.[4]

References edit

  1. ^ a b Mühlbacher JM (1991). "Naftifine: a topical allylamine antifungal agent". Clinics in Dermatology. 9 (4): 479–85. doi:10.1016/0738-081x(91)90076-w. PMID 1822408.
  2. ^ Robertson DB, Maibach HI (2009). "Dermatologic Pharmacology.". In Katzung BG, Masters SB, Trevor AJ (eds.). Basic and Clinical Pharmacology (11th ed.). New York: McGraw Hill Medical. ISBN 978-0-07-160406-2.
  3. ^ a b Naftifine Hydrochloride. Micromedex DRUGDEX Drug Point (Report). 18 February 2010..
  4. ^ Sebela Pharmaceuticals Inc. (April 2018). "NAFTIN®- naftifine hydrochloride gel" (PDF). www.accessdata.fda.gov. Retrieved 2022-07-03.