Blome was born in Bonn. He studied at the Henri-Nannen-Schule in Hamburg. From 1991 to 1993, he worked for newspaper Der Tagesspiegel. From 1993 to 2013, he worked for German newspaper Bild. From 2013 to 2015, Blome worked as journalist for the news magazine Der Spiegel. As of 2015^[update], Blome has been working again for Bild, this time in the position of the vice editor-in-chief. He was also editor-in-chief of the Bild offshoot Bild Politik.

• International Journalists' Programmes (IJP), Member of the Board of Trustees^[1]

• Faul, korrupt und machtbesessen? Warum Politiker besser sind als ihr Ruf. wjs Verlag, Berlin 2008, ISBN 978-3-937989-42-6.
• Der kleine Wählerhasser. Was Politiker wirklich über die Bürger denken. Pantheon Verlag, Munich 2011, ISBN 978-3-570-55140-0.
• Angela Merkel. Die Zauder-Künstlerin. Pantheon Verlag, Munich 2013, ISBN 978-3-570-55201-8.

• Arthur-F.-Burns-Fellowship (1993)
• Förderpreis by Friedrich und Isabel Vogel-Stiftung (1994)^[2]
• Förderpreis for Wirtschaftspublizistik by Ludwig-Erhard-Stiftung (1995)^[3]
• Deutsch-Französischer Journalistenpreis – Special award by Asko Europa-Stiftung (1996)^[4]
• Theodor Wolff Prize (2007)
• State Street-Award for Finanzjournalisten (2011)
• Herbert Quandt Medien-Award (2011)
• Henri Nannen Prize (2014) for best investigative work (together with nine other journalists at SPIEGEL)

• Literature by and about Nikolaus Blome in the German National Library catalogue
• Works by and about Nikolaus Blome in the Deutsche Digitale Bibliothek (German Digital Library)
• Articles by Nikolaus Blome (Spiegel Online)