Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research. It is one of the few opioid antagonists available that is highly selective for the κ-opioid receptor, and blocks this receptor without affecting the μ- or δ-opioid receptors,[1][2] although it is less selective in vivo than in isolated tissues.[3] nor-BNI blocks the effects of κ-opioid agonists in animal models,[4][5] and produces antidepressant[6] and anxiolytic-like effects.[2]
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Formula | C40H43N3O6 |
Molar mass | 661.799 g·mol−1 |
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