OR2AG1 Knowpia

OR2AG1
Identifiers
Aliases	OR2AG1, OR11-79, OR2AG3, olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene), olfactory receptor family 2 subfamily AG member 1
External IDs	MGI: 3030539 HomoloGene: 128075 GeneCards: OR2AG1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,791,558 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	106,476,098 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; sural nerve; ; superior frontal gyrus; ; prefrontal cortex; ; temporal lobe; ; amygdala;
	Top expressed in
	respiratory epithelium; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; olfactory receptor activity; G protein-coupled receptor activity; protein binding;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	144125
	259034
	ENSG00000279486
	ENSMUSG00000109058
	Q9H205
	Q9EPF7
	NM_001004489
	NM_147032
	NP_001004489
	NP_667243
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands edit

Amyl butyrate is a reported ligand for this receptor. ^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000279486 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109058 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1".
^ Shepard BD, Pluznick JL (May 2016). "How does your kidney smell? Emerging roles for olfactory receptors in renal function". Pediatric Nephrology (Berlin, Germany). 31 (5): 715–23. doi:10.1007/s00467-015-3181-8. PMC 4752438. PMID 26264790.