OR2L13 Knowpia

OR2L13
Identifiers
Aliases	OR2L13, OR2L14, olfactory receptor family 2 subfamily L member 13
External IDs	MGI: 3030000 HomoloGene: 88350 GeneCards: OR2L13
Gene location (Human)
Chr.	Chromosome 1 (human)
End	248,101,103 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	19,308,632 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; hypothalamus; ; endothelial cell; ; substantia nigra; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; amygdala; ; hippocampus proper;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	284521
	259071
	ENSG00000196071
	ENSMUSG00000056822
	Q8N349
	Q8VGX2
	NM_001304535; NM_175911; NM_001395936
	NM_147068
	NP_001291464; NP_787107
	NP_667279
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2L13 is a protein that in humans is encoded by the OR2L13 gene.^[5]

Function edit

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5] OR2L13 was recently implicated in regulating platelet reactivity and growth of abdominal aortic aneurysms ^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196071 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056822 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2L13 olfactory receptor, family 2, subfamily L, member 13".
^ Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P, et al. (May 2022). "Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms". The Journal of Clinical Investigation. 132 (9). doi:10.1172/JCI152373. PMC 9057618. PMID 35324479.