OR2M3 Knowpia

OR2M3
Identifiers
Aliases	OR2M3, OR1-54, OR2M3P, OR2M6, OST003, olfactory receptor family 2 subfamily M member 3
External IDs	MGI: 3029998 HomoloGene: 51725 GeneCards: OR2M3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	248,212,925 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	19,132,814 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; rectum; ; endometrium; ; renal cortex; ; prefrontal cortex; ; fundus;
	Top expressed in
	spleen; ; uterus; ; thymus; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	127062
	258443
	ENSG00000228198
	ENSMUSG00000050742
	Q8NG83
	Q8VF87
	NM_001004689
	NM_146451
	NP_001004689
	NP_666662
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

OR2M3 has a copper binding pocket.^[6]

Ligands edit

3-Mercapto-2-methylpentan-1-ol ^[7]

This chemical is associated with characteristic smell of raw onions.

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000228198 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050742 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2M3 olfactory receptor, family 2, subfamily M, member 3".
^ Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (August 2019). "Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3". Cellular and Molecular Life Sciences. 77 (11): 2157–2179. doi:10.1007/s00018-019-03279-y. PMC 7256108. PMID 31435697.
^ Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (March 2017). "OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol". Chemical Senses. 42 (3): 195–210. doi:10.1093/chemse/bjw118. PMID 27916748.