OR2T11 Knowpia

OR2T11
Identifiers
Aliases	OR2T11, OR2T11Q, olfactory receptor family 2 subfamily T member 11 (gene/pseudogene), olfactory receptor family 2 subfamily T member 11
External IDs	HomoloGene: 84585 GeneCards: OR2T11
Gene location (Human)
Chr.	Chromosome 1 (human)
End	248,635,091 bp
RNA expression pattern
	Top expressed in
	kidney; ; kidney;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; olfactory receptor activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	127077
	n/a
	ENSG00000279301
	n/a
	Q8NH01
	n/a
	NM_001001964
	n/a
	NP_001001964
	n/a
	Wikidata
View/Edit Human

Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene.^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[3]

Ligands edit

tert-Butylthiol (the response is enhanced by the presence of ionic copper).^[4]
Ethanethiol (the response is enhanced by the presence of ionic copper).^[4]
2-Propenethiol (allyl mercaptan) (the response is enhanced by the presence of ionic copper).^[4]
Thietane (the response is enhanced by the presence of ionic copper).^[4]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000279301 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
^ ^a ^b ^c ^d Li, S.; et al. (2016). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID 27659093.