OR51E2 Knowpia

OR51E2
Identifiers
Aliases	OR51E2, OR51E3P, OR52A2, PSGR, olfactory receptor family 51 subfamily E member 2, HPRAJ
External IDs	OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	4,697,854 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	102,408,678 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; popliteal artery; ; prostate; ; right coronary artery; ; smooth muscle tissue; ; transverse colon; ; rectum; ; left coronary artery; ; placenta; ; myometrium;
	Top expressed in
	belly cord; ; carotid body; ; trigeminal ganglion; ; digastric muscle; ; extraocular muscle; ; temporal muscle; ; triceps brachii muscle; ; respiratory epithelium; ; olfactory epithelium; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; olfactory receptor activity; G protein-coupled receptor activity; steroid hormone receptor activity; signaling receptor activity;
Cellular component	membrane; integral component of membrane; plasma membrane; early endosome membrane; intracellular organelle; endosome;
Biological process	sensory perception of smell; steroid hormone mediated signaling pathway; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; positive regulation of blood pressure; cellular response to fatty acid; positive regulation of renin secretion into blood stream; G protein-coupled receptor signaling pathway; cell migration; melanocyte differentiation; positive regulation of cAMP-mediated signaling; melanocyte proliferation;
	Sources:Amigo / QuickGO
Orthologs
	81285
	170639
	ENSG00000167332
	ENSMUSG00000043366
	Q9H255
	Q8VBV9
	NM_030774
	NM_001168503; NM_130866
	NP_110401
	NP_001161975; NP_570936
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.^[5]^[6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

Structure edit

Structure of the olfactory receptor OR51E2 (green) complexed with miniGs399 and a propionic acid ligand (orange).^[7]

Its structure was determined in 2023, the first elucidation of the structure of a human olfactory receptor.^[7]^[8]^[9]

Ligands edit

OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.^[10]

OR51E2 responds to short-chain fatty acids,^[11] including in particular propionic acid.^[10]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167332 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043366 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. (December 2000). "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Research. 60 (23): 6568–6572. PMID 11118034.
^ ^a ^b "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2".
^ ^a ^b PDB: 8F76; Billesbølle CB, de March CA, van der Velden WJ, Ma N, Tewari J, Del Torrent CL, et al. (March 2023). "Structural basis of odorant recognition by a human odorant receptor". Nature. 615 (7953): 742–749. Bibcode:2023Natur.615..742B. doi:10.1038/s41586-023-05798-y. PMC 10580732. PMID 36922591. S2CID 254975795.
^ Kim SE (2023). "Scientists sniff out the structure of a human olfactory receptor". Chemical & Engineering News. 101 (10): 6. doi:10.1021/cen-10110-scicon3.
^ Parry W (1 May 2023). "How a Human Smell Receptor Works Is Finally Revealed". Quanta Magazine.
^ ^a ^b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
^ Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.