Along its path, State Route 568 passes through eastern Hancock County and northwestern Wyandot County. There are no segments of State Route 568 that are incorporated within the National Highway System, a network of highways deemed most important for the economy, mobility and defense of the country.^[4] The road acts as an original to route to travel from Carey to Findlay, but now acts as an overflow road. It has mainly local cars and trucks traveling on it.

State Route 568 was established in 1965. With the completion of a new four-lane divided expressway from Interstate 75 south of Findlay and U.S. Route 23/State Route 103 south of Carey, the State Route 15 designation, which had utilized a two-lane roadway between downtown Findlay and downtown Carey to that point, was transferred onto the new expressway, which parallels the two-lane road to the south. Consequently, this two-lane highway became known as State Route 568. The route has utilized the same alignment from inception to this day, and has not seen any significant changes since its original designation.^[2][3]

Prior to the presently designated Route 568, a previous Route 568 traversed northern Lucas County and Fulton County. Established around 1939, its western terminus was the Ohio–Michigan line west of Lyons and the eastern terminus was at U.S. Route 25 (North Detroit Avenue) in Toledo.^[5] However, within a year, the part west of old U.S. 223 (present day Monroe Street and Alexis Road in Sylvania) was renamed Route 120 due to difference of traffic.^[6] Subsequently only the portion east of Monroe Street remained as Route 568, entirely encompassing Alexis Road. It was decommissioned as a state route around 1953 and designated as a bypass for U.S. 24 and U.S. 25.^[7] It was recommissioned as State Route 184 in 1969.^[8][9]