Ōkubo (大久保), also Okubo, Ookubo and Ohkubo, is a Japanese surname. Notable people with the surname include:

• Ōkubo clan
  • Ōkubo Tadayo (1532–1594), Japanese daimyō of the Sengoku period
  • Ōkubo Tadasuke (1537–1613), Japanese daimyō of the Sengoku and Edo periods
  • Ōkubo Nagayasu (1545–1613), Japanese samurai of the Edo period
  • Ōkubo Tadachika (1553–1628), Japanese daimyō of the Sengoku and Edo periods
  • Ōkubo Tadataka (1560–1639), Japanese samurai of the Sengoku and Edo periods
  • Ōkubo Tadazane (1778–1837), Japanese daimyō of the late Edo period
  • Ōkubo Toshimichi (1830–1878), Japanese samurai and later leader of the Meiji restoration

Contemporary

• Atsushi Ōkubo, Japanese manga author
• Benji Okubo, American artist
• Hiroshi Okubo, Japanese video game music composer
• James K. Okubo, American Medal of Honor recipient
• Ōkubo Haruno, Japanese general
• Hideo Ohkubo, Japanese businessman
• Jin Okubo (大久保 陣, born 1988), Japanese cyclist
• Katsutoshi Okubo (大久保 勝利, born 1943), Japanese Nordic combined skier
• Kayoko Okubo, Japanese comedian
• Kiyoshi Ōkubo, Japanese serial killer
• Mariko Okubo, Japanese actress
• Miné Okubo, American artist
• Tsutomu Okubo, Japanese politician
• Susumu Ōkubo, who proposed the Gell-Mann–Okubo mass formula
• Yasuhiro Okubo (大久保 康裕, born 1961), Japanese sport wrestler
• Yukishige Okubo, Japanese politician
• Yuri Okubo (大久保 勇利, born 2000), Japanese snowboarder

Footballers

• Goshi Okubo, Japanese footballer
• Makoto Okubo, Japanese footballer
• Takuo Ōkubo, Japanese footballer
• Tetsuya Ōkubo, Japanese footballer
• Yoshito Ōkubo, Japanese footballer
• Yuki Okubo, Japanese footballer