Opticin Knowpia

OPTC
Identifiers
Aliases	OPTC, OPT, opticin
External IDs	OMIM: 605127 MGI: 2151113 HomoloGene: 8652 GeneCards: OPTC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,508,949 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	133,835,737 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; smooth muscle tissue; ; placenta; ; myometrium; ; left uterine tube; ; urinary bladder; ; sensory organ; ; face; ; gastric mucosa;
	Top expressed in
	ascending aorta; ; aortic valve; ; lens; ; urinary bladder; ; iris; ; uterus; ; left colon; ; duodenum; ; stomach; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	extracellular region; extracellular matrix;
Biological process	extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
	26254
	269120
	ENSG00000188770
	ENSMUSG00000010311
	Q9UBM4
	Q920A0
	NM_014359
NM_001160420; NM_001160421; NM_001160422; NM_054076; NM_001395557;
	NM_001395558
	NP_055174
NP_001153892; NP_001153893; NP_001153894; NP_473417; NP_001382486;
	NP_001382487
	Wikidata
View/Edit Human	View/Edit Mouse

Opticin is a protein that in humans is encoded by the OPTC gene.^[5]^[6]

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188770 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010311 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN (Feb 2000). "Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix". J Biol Chem. 275 (3): 2123–9. doi:10.1074/jbc.275.3.2123. PMID 10636917.
^ ^a ^b "Entrez Gene: OPTC opticin".

Further reading edit

Hobby P, Wyatt MK, Gan W, et al. (2000). "Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye". Mol. Vis. 6: 72–8. PMID 10837509.
Friedman JS, Ducharme R, Raymond V, Walter MA (2000). "Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection". Invest. Ophthalmol. Vis. Sci. 41 (8): 2059–66. PMID 10892843.
Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS (2001). "Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity". Int. Arch. Allergy Immunol. 126 (1): 78–90. doi:10.1159/000049497. PMID 11641609. S2CID 45610233.
Friedman JS, Faucher M, Hiscott P, et al. (2002). "Protein localization in the human eye and genetic screen of opticin". Hum. Mol. Genet. 11 (11): 1333–42. doi:10.1093/hmg/11.11.1333. PMID 12019215.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Le Goff MM, Hindson VJ, Jowitt TA, et al. (2003). "Characterization of opticin and evidence of stable dimerization in solution". J. Biol. Chem. 278 (46): 45280–7. doi:10.1074/jbc.M303117200. PMID 12951322.
Ramesh S, Bonshek RE, Bishop PN (2004). "Immunolocalisation of opticin in the human eye". The British Journal of Ophthalmology. 88 (5): 697–702. doi:10.1136/bjo.2003.031989. PMC 1772128. PMID 15090426.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Acharya M, Mookherjee S, Bhattacharjee A, et al. (2007). "Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change". BMC Mol. Biol. 8: 21. doi:10.1186/1471-2199-8-21. PMC 1838427. PMID 17359525.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188770 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010311 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10636917-5] Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN (Feb 2000). "Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix". J Biol Chem. 275 (3): 2123–9. doi:10.1074/jbc.275.3.2123. PMID 10636917.

[entrez-6] "Entrez Gene: OPTC opticin".

[5]

[6]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit