Org 28611

Summary

Org 28611 (SCH-900,111) is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors. It was developed with the aim of finding a water-soluble cannabinoid agonist suitable for intravenous use as an analgesic,[1] and while it achieved this aim and has progressed as far as Phase II clinical trials in humans as both a sedative and an analgesic, results against the comparison drugs (midazolam and morphine respectively) were not particularly favourable in initial testing.[2][3]

Org 28611
Legal status
Legal status
Identifiers
  • [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3S)-3,4-dimethylpiperazin-1-yl]methanone
CAS Number
  • 639068-99-8 ☒N
PubChem CID
  • 10091392
ChemSpider
  • 8266929 checkY
UNII
  • 1U7V49NTQG
ChEMBL
  • ChEMBL1209709 checkY
Chemical and physical data
FormulaC23H33N3O2
Molar mass383.536 g·mol−1
3D model (JSmol)
  • Interactive image
  • COc3cccc(c13)c(C(=O)N(CC2C)CCN2C)cn1CC4CCCCC4
  • InChI=1S/C23H33N3O2/c1-17-14-25(13-12-24(17)2)23(27)20-16-26(15-18-8-5-4-6-9-18)22-19(20)10-7-11-21(22)28-3/h7,10-11,16-18H,4-6,8-9,12-15H2,1-3H3/t17-/m0/s1 checkY
  • Key:ONXJNAIZJKLJGA-KRWDZBQOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

See also edit

References edit

  1. ^ Adam, J. M.; et al. (2010). "Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists". MedChemComm. Royal Society of Chemistry. 1: 54. doi:10.1039/c0md00022a.
  2. ^ Zuurman L, Passier PC, de Kam M, Kleijn HJ, Cohen AF, van Gerven JM (August 2009). "Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers". Journal of Psychopharmacology. 23 (6): 633–44. doi:10.1177/0269881108091551. PMID 18635703. S2CID 43609218.
  3. ^ A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery