PFKFB1 Knowpia

PFKFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790 MGI: 107816 HomoloGene: 105654 GeneCards: PFKFB1
Gene location (Human)
Chr.	X chromosome (human)
End	54,998,534 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	149,426,874 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gastrocnemius muscle; ; vastus lateralis muscle; ; biceps brachii; ; triceps brachii muscle; ; deltoid muscle; ; adipose tissue; ; subcutaneous adipose tissue; ; abdominal fat; ; tibialis anterior muscle;
	Top expressed in
	sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; masseter muscle; ; tibialis anterior muscle; ; temporal muscle; ; digastric muscle; ; gastrocnemius muscle; ; right ventricle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; fructose-6-phosphate binding; kinase activity; catalytic activity; protein binding; identical protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; ATP binding; 6-phosphofructo-2-kinase activity; kinase binding;
Cellular component	cytosol; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;
Biological process	gluconeogenesis; response to glucagon; glycolytic process; phosphorylation; fructose metabolic process; response to glucocorticoid; carbohydrate phosphorylation; response to insulin; positive regulation of glucokinase activity; fructose 2,6-bisphosphate metabolic process; animal organ regeneration; response to starvation; metabolism; response to cAMP; dephosphorylation; negative regulation of glycolytic process; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5207
	18639
	ENSG00000158571
	ENSMUSG00000025271
	P16118
	P70266
	NM_001271804; NM_001271805; NM_002625
NM_008824; NM_001374170; NM_001374171; NM_001374172; NM_001374173;
	NM_001374175
	NP_001258733; NP_001258734; NP_002616
NP_032850; NP_001361099; NP_001361100; NP_001361101; NP_001361102;
	NP_001361104
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.^[5]^[6]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158571 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025271 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
^ ^a ^b "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

Further reading edit

Lange AJ, Pilkis SJ (1990). "Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Nucleic Acids Res. 18 (12): 3652. doi:10.1093/nar/18.12.3652. PMC 331036. PMID 2163524.
Marker AJ, Colosia AD, Tauler A, et al. (1989). "Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression". J. Biol. Chem. 264 (12): 7000–4. doi:10.1016/S0021-9258(18)83531-1. PMID 2540168.
Algaier J, Uyeda K (1988). "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase". Biochem. Biophys. Res. Commun. 153 (1): 328–33. doi:10.1016/S0006-291X(88)81226-9. PMID 2837207.
Lee YH, Li Y, Uyeda K, Hasemann CA (2003). "Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". J. Biol. Chem. 278 (1): 523–30. doi:10.1074/jbc.M209105200. PMID 12379646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158571 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025271 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119406-5] Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.

[entrez-6] "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

[5]

[6]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit