Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene.[5] It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.[6]
PIEZO2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PIEZO2, C18orf30, C18orf58, DA3, DA5, FAM38B, FAM38B2, HsT748, HsT771, MWKS, piezo type mechanosensitive ion channel component 2, DAIPT | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 613629 MGI: 1918781 HomoloGene: 49695 GeneCards: PIEZO2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.[7] Its structure is resolved via a mouse version in 2019, showing the predicted homotrimeric propeller.[8]
PIEZO2 is typically found in cell types that respond to physical touch, such as Merkel cells,[9] and is thought to regulate light touch response.[10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.