POLD2 Knowpia

POLD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E0J
Identifiers
Aliases	POLD2, DNA polymerase delta 2, accessory subunit
External IDs	OMIM: 600815 MGI: 1097163 HomoloGene: 4538 GeneCards: POLD2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,124,358 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,828,292 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of liver; ; body of pancreas; ; skin of abdomen; ; ganglionic eminence; ; anterior pituitary; ; gastrocnemius muscle; ; left uterine tube; ; tibial nerve; ; popliteal artery;
	Top expressed in
	yolk sac; ; internal carotid artery; ; maxillary prominence; ; external carotid artery; ; medial ganglionic eminence; ; abdominal wall; ; primitive streak; ; dermis; ; endocardial cushion; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-directed DNA polymerase activity;
Cellular component	nucleoplasm; nucleus; delta DNA polymerase complex;
Biological process	nucleotide-excision repair, DNA gap filling; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; telomere maintenance; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; DNA strand elongation involved in DNA replication; cellular response to DNA damage stimulus; telomere maintenance via semi-conservative replication; DNA mismatch repair; DNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5425
	18972
	ENSG00000106628
	ENSMUSG00000020471
	P49005
	O35654
	NM_001127218; NM_001256879; NM_006230
	NM_008894; NM_001361942
	NP_001120690; NP_001243808; NP_006221
	NP_032920; NP_001348871
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^[5]^[6] It is a component of the DNA polymerase delta complex.

Interactions edit

POLD2 has been shown to interact with PCNA.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106628 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020471 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
^ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
^ Lu X, Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27). United States: 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310.

Further reading edit

Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)". Genomics. 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID 9286699.
Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID 10811112.
Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724.
Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta. 1493 (1–2): 231–6. doi:10.1016/s0167-4781(00)00153-6. PMID 10978529.
Szekely AM, Chen YH, Zhang C, Oshima J, Weissman SM (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. Bibcode:2000PNAS...9711365S. doi:10.1073/pnas.97.21.11365. PMC 17206. PMID 11027336.
He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
Lu X, Tan CK, Zhou JQ, You M, Carastro LM, Downey KM, So AG (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. PMID 11986310.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tsurimoto T, Shinozaki A, Yano M, Seki M, Enomoto T (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.