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POLD4

Summary

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene.[5] It is a component of the DNA polymerase delta complex.

POLD4
Identifiers
AliasesPOLD4, POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit
External IDsOMIM: 611525 MGI: 1916995 HomoloGene: 10909 GeneCards: POLD4
Orthologs
SpeciesHumanMouse
Entrez

57804

69745

Ensembl

ENSG00000175482

ENSMUSG00000024854

UniProt

Q9HCU8

Q9CWP8

RefSeq (mRNA)

NM_001256870
NM_021173

NM_027196

RefSeq (protein)

NP_001243799
NP_066996

NP_081472

Location (UCSC)Chr 11: 67.35 – 67.36 MbChr 19: 4.28 – 4.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024854 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: polymerase (DNA-directed)".

Further reading edit

  • Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme". Biochemistry. 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614.
  • Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta". Nucleic Acids Res. 36 (16): 5166–79. doi:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.
  • Bae SH, Bae KH, Kim JA, Seo YS (2001). "RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes". Nature. 412 (6845): 456–61. doi:10.1038/35086609. PMID 11473323. S2CID 4337704.
  • Matsumoto Y, Kim K, Hurwitz J, et al. (1999). "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins". J. Biol. Chem. 274 (47): 33703–8. doi:10.1074/jbc.274.47.33703. PMID 10559261.
  • Liu G, Warbrick E (2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
  • Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
  • Wood RD, Shivji MK (1997). "Which DNA polymerases are used for DNA-repair in eukaryotes?". Carcinogenesis. 18 (4): 605–10. doi:10.1093/carcin/18.4.605. PMID 9111189.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huang QM, Akashi T, Masuda Y, et al. (2010). "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells". Biochem. Biophys. Res. Commun. 391 (1): 542–6. doi:10.1016/j.bbrc.2009.11.094. PMID 19931513.
  • Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
  • Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). "Identification of a fourth subunit of mammalian DNA polymerase delta". J. Biol. Chem. 275 (25): 18739–44. doi:10.1074/jbc.M001217200. PMID 10751307.