POLE3 Knowpia

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267 MGI: 1933378 HomoloGene: 9694 GeneCards: POLE3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,410,675 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,443,305 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; monocyte; ; human penis; ; ganglionic eminence; ; rectum; ; bone marrow; ; cerebellar hemisphere; ; right adrenal gland; ; skin of abdomen; ; left adrenal gland;
	Top expressed in
	spermatocyte; ; yolk sac; ; secondary oocyte; ; seminiferous tubule; ; morula; ; molar; ; maxillary prominence; ; ganglionic eminence; ; medial ganglionic eminence; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; protein heterodimerization activity; histone acetyltransferase activity;
Cellular component	epsilon DNA polymerase complex; nucleus; nucleoplasm;
Biological process	DNA replication; histone H3 acetylation; DNA biosynthetic process; G1/S transition of mitotic cell cycle; cellular response to DNA damage stimulus; CENP-A containing chromatin assembly; cellular response to gamma radiation; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	54107
	59001
	ENSG00000148229
	ENSMUSG00000028394
	Q9NRF9
	Q9JKP7
	NM_001278255; NM_017443
	NM_021498
	NP_001265184; NP_059139
	NP_067473
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.^[5]^[6]^[7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[7]

Interactions edit

POLE3 has been shown to interact with SMARCA5.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
^ ^a ^b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
^ ^a ^b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Further reading edit

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Bolognese F, Imbriano C, Caretti G, Mantovani R (2000). "Cloning and characterization of the histone-fold proteins YBL1 and YCL1". Nucleic Acids Res. 28 (19): 3830–8. doi:10.1093/nar/28.19.3830. PMC 110757. PMID 11000277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10801849-5] Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

[pmid10880450-6] Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.

[entrez-7] "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

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[7]

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Summary

Interactions edit

References edit

Further reading edit