POU4F2 Knowpia

POU4F2
Identifiers
Aliases	POU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs	OMIM: 113725 MGI: 102524 HomoloGene: 20959 GeneCards: POU4F2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	146,642,474 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pons; ; pancreatic ductal cell; ; sensory ganglion; ; trigeminal ganglion; ; ventral tegmental area; ; medulla oblongata; ; superior vestibular nucleus; ; testicle; ; renal cortex;
	Top expressed in
	trigeminal ganglion; ; superior colliculus; ; morula; ; otolith organ; ; inferior colliculus; ; utricle; ; ganglion cell layer; ; pontine nuclei; ; neural tube; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription coactivator activity; transcription corepressor activity; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding;
Cellular component	nucleoplasm; nucleus; nuclear speck; cytoplasm; plasma membrane; membrane; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; axonogenesis; neuromuscular process controlling balance; sensory perception of sound; transcription, DNA-templated; MAPK cascade; axon guidance; retina development in camera-type eye; positive regulation of cell differentiation; spermatogenesis; neuron differentiation; axon extension; intracellular estrogen receptor signaling pathway; retinal ganglion cell axon guidance; regulation of signal transduction by p53 class mediator; transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of programmed cell death; negative regulation of cell differentiation; positive regulation of osteoclast differentiation; positive regulation of axon extension; regulation of DNA-binding transcription factor activity; cellular response to cytokine stimulus; cellular response to estradiol stimulus; intrinsic apoptotic signaling pathway by p53 class mediator; regulation of retinal ganglion cell axon guidance; negative regulation of amacrine cell differentiation; dorsal root ganglion development; positive regulation of transcription regulatory region DNA binding; apoptotic process; multicellular organism development; cell differentiation; negative regulation of transcription by RNA polymerase II; heart development; regulation of gene expression; positive regulation of cardiac muscle cell apoptotic process; cellular response to insulin stimulus; positive regulation of glucose import; cellular response to oxygen levels; negative regulation of adipose tissue development;
	Sources:Amigo / QuickGO
Orthologs
	5458
	18997
	ENSG00000151615
	ENSMUSG00000031688
	Q12837
	Q63934
	NM_004575
	NM_138944
	NP_004566
	NP_620394
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.^[4]^[5]

Function edit

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]^[5]

Interactions edit

POU4F2 has been shown to interact with Estrogen receptor alpha.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151615 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
^ ^a ^b "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
^ Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.