• Painkiller (video game), a 2004 first-person shooter for the PC and Xbox
  • Painkiller: Resurrection, an expansion pack for the 2004 game
  • Painkiller: Hell & Damnation, a remake of the 2004 game

Bands edit

• Painkiller (band), a band led by John Zorn and Bill Laswell

Albums edit

• Pain Killer (Energy Orchard album), 1995
• Pain Killer (Krokus album), 1978
• Pain Killer (Little Big Town album), 2014
• Pain Killer (Moumoon album), 2013
• Painkiller (Jim Bianco album), 2006
• Painkiller (Judas Priest album), 1990
• Painkiller, a 2012 re-release edition of the EP Russian Roulette, or the song
• Painkillers (EP), a 1993 EP by Babes in Toyland

Songs edit

• "Pain Killer" (Iceage song), 2018
• "Painkillerr" a song by Polish band Mech
• "Pain Killer" (Little Big Town song), 2015
• "Pain Killer" (Turin Brakes song), 2003
• "Painkiller" (Freestylers song), 2006
• "Painkiller" (Jason Derulo song), 2015
• "Painkiller" (Judas Priest song), 1990
• "Painkiller" (Ruel song), 2019
• "Painkiller" (Three Days Grace song), 2014
• "Painkiller", a song by Depeche Mode, the B-side of "Barrel of a Gun"
• "Painkiller", a song by Dreamers from This Album Does Not Exist

• Painkiller (TV series), a 2023 American drama limited series
• "Painkiller" (Black Lightning episode)
• Painkiller (Arrowverse)

• Painkiller (cocktail), a rum cocktail
• Painkiller (comics), a fictional DC Comics supervillain
• Painkiller (magazine), a Chinese heavy metal music magazine
• The Painkiller (play), by Sean Foley, adapted from Francis Veber's Le Contract
• Painkiller, a 2011 short film starring Benedict Wong
• Painkillers (film), a 2018 film directed by Roxy Shih