Palazzo Baldassini is a palace in Rome, Italy, designed by the Renaissance architect Antonio da Sangallo the Younger in about 1516–1519. It was designed for the papal jurist from Naples, Melchiorre Baldassini. The ground floor was used for shops or workshops, and the piano nobile consisted of private apartments.

Palazzo Baldassini
Gate of Palazzo Baldassini
General information
Architectural style	Renaissance
Location	Rome, Italy
Design and construction
Architect(s)	Antonio da Sangallo the Younger

The interior was frescoed by Giovanni da Udine, Perin del Vaga, Polidoro da Caravaggio and Maturino da Firenze.