Pan Am Cargo or Clipper Cargo was a subsidiary cargo airline of Pan American World Airways. Pan Am Cargo first used piston-engined aircraft such as the Douglas DC-4. On 5 January 1952 the larger DC-6 model was used on the company's first transatlantic all-cargo service. In 1963, Pan Am's all-cargo jet service began with Boeing 707-321Cs that henceforth dominated Pan Am's freight operations.

Pan Am stopped Pan Am Cargo operations in 1983.^[1]