Panayiotis was born in a small village named Koutifari close to Kalamata in the Peloponnese region. His father's name was Nicholas. Panayiotis family moved to Zakynthos when he was a young age. His parents signed an agreement with famous painter Leos Moskos to teach him painting. He traveled with the artist to Venice. Panayiotis married into the Bon family she was catholic. They had eight children. He had six daughters and two sons. His two sons Nicholas and Demetrios became famous painters.^[4]

By age thirty, he was a soldier. He fought for the Venetian Empire. He fought in the Peloponnese region for five years against the Ottoman Empire. In 1699, he traveled to Venice and studied Italian painting for five years. He started to become a theoretical painter. He became interested in the science of painting. He settled in Kalamata with his family until 1715. When the area was invaded he fled with his family to Lefkada and in 1720 he traveled back to Venice.^[5]

While Panayiotis was in Venice he translated books into Greek from Italian. He translated Trattato de la pittura de Leonardo da Vinci. Panayiotis admired Leonardo da Vinci and some of his works resemble Leonardo's Virgin of the Rocks. He also translated the works of Leon-Battista Alberti, Andrea Pozzo, and a massive catalog with the most famous painters in the world. His book Common Teaching (Keni Didaskalia) was inspired by Marco Boschini's, Le Ricche Minere della Pittura Veneziana.^[6]

In 1721, the Venetian government gave Panayiotis land in Lefkada, but in 1722 he preferred to move to Corfu. While he was in Corfu. Panayiotis published his book Common Teaching (Keni Didaskalia) in 1726. One year later he painted Agios Spiridonas church. He also painted the ceiling of Panagia Faniromeni in Zakynthos. The work was a masterpiece resembling Michelangelo's Sistine Chapel ceiling. He died in 1729. Panayiotis is considered one of the masters of theoretical painting in the 18th century. He inspired many Greek and Italian painters.^[7][8][9]

Panayioti's work signals a departure from Greek painting, namely the Cretan school and maniera greca towards Western European Renaissance art. Many Greek artists already started this transition namely: Ioannis Permeniates, Thomas Bathas, Michael Damaskinos, Theodore Poulakis and Elias Moskos to name a few. Panayiotis admired the Italian masters particularly Leonardo da Vinci, whose book Art of painting (Trattato della pittura) he translated into Greek.^[10]

In 1726, he wrote the famous, albeit controversial and debated theoretical text On painting (Περί ζωγραφίας). He addressed the need for Greek art to depart from Byzantine maniera greca towards Western European art. The article was originally published after Doxaras's death in 1871. His article is debated among scholars namely in Greece.^[11]

He was one of the first Greek painters that tried to realistically depict human faces in religious themes. Doxaras also introduced oil painting into Greek iconography. He tried to replace the old method of mixing pigments with egg yolk.^[12] He painted the roof of Agios Spyridonas in Corfu. He was inspired by the works of Paolo Veronese. The images faded and in the middle of the 19th century and were replaced with newer ones painted by Nikolaos Aspiotis.^[13] Doxaras also painted some portraits, his most famous portrait was that of Count Graf von der Schulenburg, leader of the Venetian army and defendant of Corfu, which he signed Panagiotis Doxaras, Lacedaemonian Horseman, 1725, May 15th (Hellenomnemon, p. 19).

•  
  Count Johann Matthias von der Schulenburg
•  
  Matthias von der Schulenburg
•  
  Archangel Michael
•  
  Saint Spyridon Church
•  
  Virgin Mary
•  
  Holy Family
•  
  The liturgy of St Spyridon, Byzantine museum, Athens
•  
  Alexander the Great

• Trattato dela Pittura de Leonardo da Vinci Greek Translation
• On painting (Περί ζωγραφίας) 1726

• Christ Megas Lady of the Angels, Zakynthos
• Saint Demetrios The Museum of Christian Art Lefkada
• The Holy Family (Doxaras) National Gallery of Athens

• Heptanese School
• Byzantine Art
• Nikolaos Kallergis