Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.[5]
PTH2R | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | PTH2R, PTHR2, parathyroid hormone 2 receptor | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601469 MGI: 2180917 HomoloGene: 3701 GeneCards: PTH2R | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.[5]
The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.