PA 114 begins at an intersection with PA 944 in Silver Spring Township, Cumberland County, heading south on two-lane undivided Conodoguinet Parkway. The road heads through areas of farms and woods, passing west of a park and ride lot and reaching a diamond interchange with I-81, where it becomes a four-lane divided highway. From this point, the route heads southeast and crosses the Conodoguinet Creek, continuing south into business areas and intersecting US 11 in Hogestown. Past this intersection, PA 114 becomes two-lane undivided Hogestown Road and runs through agricultural areas with some housing developments, curving southeast. The road heads through residential areas as it turns south and comes into the borough of Mechanicsburg, with the road name becoming North York Street. Here, the route passes industrial areas to the west and homes to the east. PA 114 enters residential and business areas as it crosses Norfolk Southern's Shippensburg Secondary railroad line at-grade and intersects PA 641, turning east to form a concurrency with that route on West Main Street. The road runs through the commercial downtown, with PA 114 splitting from PA 641 by turning south onto South Market Street.^[2][3]

The route continues past several homes, crossing into Upper Allen Township. The road briefly becomes the border between Upper Allen Township to the west and Mechanicsburg to the east before fully entering Upper Allen Township again and running through areas of farmland and housing developments, crossing over I-76 (Pennsylvania Turnpike). PA 114 continues south through residential subdivisions with some commercial establishments, reaching a diamond interchange with the US 15 freeway. The route continues southeast past more suburban development, turning east onto East Lisburn Road in Bowmansdale. PA 114 heads north-northeast into agricultural areas, turning southeast to pass under Norfolk Southern's Lurgan Branch railroad line before resuming north-northeast. The road continues east through a mix of farmland and woodland with some homes, crossing into Lower Allen Township and running through the residential community of Lisburn on Main Street.^[2][3]

PA 114 crosses the Yellow Breeches Creek into Fairview Township in York County and becomes Cedars Road, heading through rural areas with a few residences. The route intersects PA 382 and turns to the north onto Lewisberry Road, curving northeast into forested areas with some homes. PA 114 comes to an intersection with PA 262 in Bunches and turns northwest to continue along Lewisberry Road. The road passes through more wooded areas before turning north and running through a mix of fields and residential development. The route curves northeast near Fair Acres and heads through more rural residential areas as it comes to a partial cloverleaf interchange with I-83. Past this, the route runs through woods and crosses under the Pennsylvania Turnpike. PA 114 runs through more residential areas prior to ending at SR 1003 (Old York Road) west of the Capital City Airport near New Market.^[2][4]

When Pennsylvania legislated routes in 1911, the portion of present-day PA 114 east of current PA 382 was designated as part of Legislative Route 250, which ran between York and the Harrisburg area. By this time, the current route east of Mechanicsburg was an unpaved road, with a small paved section to the west of the Yellow Breeches Creek.^[5] PA 114 was designated in 1928 to run from US 11 in Hogestown south and east to Lisburn, where an unnumbered, unpaved road continued east to PA 24 (now PA 382). The present-day route east of there was designated as the northernmost part of PA 24, which reached its northern terminus at US 111 (Old York Road) in New Market. At this time, the entire length of PA 114 along with this section of PA 24 was paved.^[6] By 1930, the road between Wertzville and Hogestown was an unnumbered, unpaved road.^[7] In the 1930s, the unnumbered roads between Wertzville and Hogestown and Lisburn and PA 24 were paved.^[8] PA 114 was extended east from Lisburn to PA 24 in the 1940s.^[9] In the 1950s, the northern terminus of PA 24 was cut back to an interchange with I-83/US 111 southwest of New Market, resulting in the road between I-83/US 111 and Old York Road becoming unnumbered.^[10] The eastern portion of PA 114 was extended north from PA 382 to Old York Road in New Market in the 1960s, replacing that portion of PA 24.^[11] In the 1970s, the route was extended north from US 11 in Hogestown to PA 944 in Wertzville, with an interchange at I-81; the portion of the road between I-81 and US 11 was widened into a divided highway.^[12]

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• Pennsylvania Highways: PA 114