PA 562 begins at an intersection with US 422 Bus. in the borough of St. Lawrence in Berks County to the east of the city of Reading. From this intersection, the route heads east as two-lane undivided St. Lawrence Avenue, passing through business areas and crossing Antietam Creek. The road curves southeast into residential areas, soon turning to the east. PA 562 leaves St. Lawrence for Exeter Township and becomes Boyertown Pike, passing through the residential community of Jacksonwald. The road continues into a mix of farmland and woodland with some homes, curving southeast as it comes to the community of Stonersville. The route heads northeast into Amity Township and continues through agricultural areas, curving east and forming the border between Oley Township to the north and Amity Township to the south. In the community of Yellow House, PA 562 crosses PA 662.^[2][3]

The road continues east through farmland and becomes the border between Earl Township to the north and Amity Township to the south as it comes to the residential community of Earlville and crosses Manatawny Creek. The route bends south to fully enter Amity Township, where it runs between woodland to the north and residential subdivisions to the south. PA 562 continues east-northeast into Earl Township and passes through a mix of farms and woods with some homes, soon entering Douglass Township. The road becomes Reading Avenue and continues through rural areas, passing through the community of Greshville. The route heads northeast into Colebrookdale Township and intersects Farmington Avenue as it passes through the residential community of Morysville. PA 562 enters the borough of Boyertown and crosses Ironstone Creek as it continues past homes and some businesses on South Reading Avenue before it reaches its eastern terminus at PA 73 in the commercial downtown. North Reading Avenue continues past this intersection as State Route 2067, an unsigned quadrant route, to an interchange with PA 100 near New Berlinville.^[2][3]

When routes were legislated in Pennsylvania in 1911, present-day PA 562 was not legislated as part of a route.^[4] By 1926, the roadway between Yellow House and Boyertown was paved.^[5] In 1927, PA 62 (later PA 100) was designated to follow Reading Avenue through Boyertown north of Farmington Avenue.^[6][7] The road between St. Lawrence and Yellow House was paved by 1928.^[7] PA 562 was designated by 1930 to run from Stonersville east to PA 62 southwest of Boyertown. The route followed Weavertown Road east to PA 662 in Amityville, where it turned north to Yellow House before continuing east along its current alignment.^[8] In the 1930s, PA 562 was extended west to US 422 (now US 422 Bus.) in St. Lawrence and was realigned to its current alignment between Stonersville and Yellow House, with an extension of PA 662 replacing the former alignment between Amityville and Yellow House.^[9] In 1964, PA 562 was extended to its current terminus at PA 73 in Boyertown, replacing a portion of PA 100 that was rerouted to a new divided highway alignment to the east.^[10][11] On June 28, 2018, a portion of PA 562 was named the General Carl A. Spaatz Memorial Highway in honor of Carl Spaatz, a World War II general. A dedication ceremony was held with State Representative David Maloney in attendance.^[12]

The entire route is in Berks County.

•   U.S. Roads portal
•   Pennsylvania portal

• Pennsylvania Highways: PA 562