PA 926 begins at an intersection with PA 10 in Upper Oxford Township, Chester County, heading northeast on two-lane undivided Street Road. The road passes through farmland with some trees and homes, crossing the East Branch Big Elk Creek into Londonderry Township. The route continues east through rural areas and passes near a few residential developments before it intersects PA 796 in the community of Daleville. PA 926 runs past more farms and reaches a junction with PA 41. Past this intersection, the road curves southeast and parallels PA 41 for a short distance before turning to the east. The route becomes the border between West Marlborough Township to the north and London Grove Township to the south, passing to the north of a landfill before it continues through more agricultural areas with some woods and homes, intersecting PA 841. Farther east, PA 926 fully enters West Marlborough Township and crosses the East Branch White Clay Creek before it reaches the community of London Grove, where it briefly turns south at an intersection with Newark Road prior to turning east again. The road continues through rural areas and briefly becomes the border between West Marlborough Township to the north and East Marlborough Township to the south before fully entering East Marlborough Township, where it passes to the north of the University of Pennsylvania's New Bolton Center and crosses the West Branch Red Clay Creek. PA 926 runs to the south of a residential development before intersecting PA 82 in Willowdale.^[2][3]

Following this intersection, the route runs east through a mix of farmland and woodland with some residential areas, heading across the East Branch Red Clay Creek. PA 926 crosses into Pennsbury Township and immediately intersects PA 52, at which point it heads more to the east-northeast. The road passes through wooded areas with some fields and residences, crossing into Pocopson Township. The route intersects Pocopson Road and crosses an East Penn Railroad line at-grade in the community of Pocopson. Past this, PA 926 crosses the Brandywine Creek into Birmingham Township. Just after crossing the Brandywine Creek, the route intersects Creek Road. The road continues northeast and runs through a mix of residential developments, fields, and woods. PA 926 becomes the border between Westtown Township to the northwest and Thornbury Township to the southeast as it passes through more suburban development with some farms. The route crosses US 202/US 322 in the community of Darlington Corners, where it passes near some commercial development.^[2][3]

The road heads through wooded areas of residential neighborhoods and reaches the community of Westtown, where it crosses the Chester Creek and passes over the West Chester Railroad before heading across the East Branch Chester Creek. PA 926 runs past residential areas with some farm fields as it passes to the north of the Cheyney University of Pennsylvania campus, with access to the university provided by Cheyney Road. The route becomes the border between Westtown Township, Chester County, to the northwest and Thornbury Township, Delaware County, to the southeast as it runs past more residential subdivisions and intersects PA 352. Past the PA 352 intersection, the road turns north to fully enter Westtown Township, Chester County, passing fields and woods. The route curves northeast again and crosses into Willistown Township, where it passes through wooded areas of homes. PA 926 reaches its eastern terminus at an intersection with PA 3, with Garrett Mill Road heading north on the other side of PA 3.^[2][3]

Street Road dates back to colonial times, when a straight road in Marlborough Township was laid out by William Penn and was named Marlborough Street, running from Pennsbury Township to the Marlborough Friends Meetinghouse. In 1815, a road was surveyed between Market Street in Philadelphia and McCalls Ferry on the Susquehanna River to facilitate the westward expansion of settlers. This new road followed the alignment of Marlborough Street. This road became known as Street Road, named after Marlborough Street that it followed.^[4] When Pennsylvania first legislated its routes in 1911, Street Road was not given a route number.^[5] By 1928, Street Road existed as a paved road between London Grove and Red Lion and from US 122/PA 29 (now US 202/US 322) in Thornbury to PA 352 in Tanguy. PA 129 was designated along the portion of road between US 122/PA 29 and PA 352. PA 926 was first designated by 1928 to run from US 122/PA 29 east to PA 129 along unpaved Oakbourne Road and paved Concord Road and Westbourne Road.^[6] By 1930, PA 926 was realigned to follow Street Road between US 122 and PA 352, replacing the PA 129 designation on this stretch which was shifted to a road further south.^[7] In 1937, PA 926 was extended along Street Road to its current length between US 122 (now PA 10) near Russellville and PA 3 near Westtown.^[8][9] By 1940, the entire route was paved.^[9] PA 926 has remained along the same alignment since.^[3]

On January 22, 2024, construction began on a roundabout at the PA 41 intersection in Londonderry Township. The roundabout is planned to cost $6.3 million and be completed in the later part of 2024.^[10]

Pennsylvania Route 926 Alternate Truck was a truck route bypassing a weight-restricted bridge over Radley Run in Thornbury Township, on which trucks over 36 tons and combination loads over 40 tons are prohibited. Formed in 2013, it followed PA 52, US 1, and US 202/US 322. In 2020, the bridge was reconstructed, and the route was decommissioned.^[11][12]

•   U.S. Roads portal
•   Pennsylvania portal

• Pennsylvania Highways: PA 926
• PA 926 at AARoads.com