Shakes-Drayton was born in east London to Christian parents from Grenada, and grew up in Bow, where she continues to reside.^[3] She attended Holy Family R.C. Primary School in Poplar and Bishop Challoner Catholic Collegiate School in Stepney.^[3] She studied sports science at Brunel University,^[3] where she graduated with a 2:1. She married high-jump athlete Mike Olayemi Edwards in London in June 2019. Shakes welcomed her first child with Edwards on 26 August 2020.^[4]

Shakes-Drayton came to prominence at the English Schools Championships where she set a UK junior record time in the 400 m hurdles.^[5] She made her first major international appearance at the 2006 World Junior Championships in Athletics where she finished eighth, achieving a new personal best of 57.52 seconds.^[6] She took the silver medal at the 2007 European Athletics Junior Championships with a time of 56.46 s, a national junior record in the event.^[7][8]

Shakes-Drayton won the 400 m hurdles at the 2008 Olympic Games GB trials, but veteran Tasha Danvers was instead chosen to represent Great Britain, and went on to win the bronze medal.^[9] Despite the non-selection, Shakes-Drayton was considered to be a medal prospect for the next Olympics in 2012.^[6] At the 2009 British Championships in Birmingham, she finished second in the 400 metres behind reigning world champion Christine Ohuruogu, setting a new personal best. Further success came on the junior circuit at the 2009 European Athletics U23 Championships, where she won the 400 m hurdles gold medal with a run of 55.26 seconds, another personal best. Having secured a place on the Great Britain team, she set her sights on the 2009 World Championships in Athletics, remarking: "I like people talking about me. It means I must be doing some things right. Now I have to live up to the hype because hype is pointless if you don't live up to it."^[10]

She ran at the 2009 World Championships in Athletics in Berlin and reached the semi-finals of the competition. However, she finished seventh in the race with a time of 57.57 seconds and did not compete in the final. She ran a personal best of 54.91 seconds for the 400 m hurdles to win at the Memorial Primo Nebiolo in June 2010.^[11]

In the absence of Tasha Danvers, Shakes-Drayton and Eilidh Child were the sole representatives for Great Britain at the 2010 European Athletics Championships. Shakes-Drayton finished 2nd in her heat, with a time of 55.35. She then finished 3rd in her semi-final to qualify for the final in a new personal best of 54.73. In the final she finished third to win the bronze medal with a new personal best of 54.18.

At the 2012 London Grand Prix, the final Diamond League meeting prior to the 2012 London Olympic Games, Shakes-Drayton recorded another personal best for the 400 m hurdles of 53.77, a time that put her second in the world rankings for the year and also made her the second-fastest British athlete of all time in the event, behind only Sally Gunnell.^[12] However, in the Olympic 400 m hurdles she was unable to reach the final, finishing third in her semi-final heat.^[13] She was also part of the GB 4 × 400 m relay team which finished fifth in the final of that event.^[14]

At the 2013 European Athletics Indoor Championships in Gothenburg, Shakes-Drayton went on to win gold in the Women's 400 m final with a Personal Best of 50.85, ahead of another Great Britain runner Eilidh Child. She was also part of the Women's 4 × 400 m team (along with Eilidh Child, Shana Cox and Christine Ohuruogu) that won gold at the same championships.^[15]

In 2020, she announced her retirement from her athletics career.^[16]

• Official website
• Perri Shakes-Drayton at World Athletics  
• Agency website