Phenylbiguanide

Summary

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Phenylbiguanide
Legal status
Legal status
  • UN: Unscheduled
Identifiers
  • 1-Phenylbiguanide
CAS Number
  • 102-02-3
PubChem CID
  • 4780
ChemSpider
  • 4616
UNII
  • W8PKA3T2I3
ChEBI
  • CHEBI:75377
ChEMBL
  • ChEMBL13791
CompTox Dashboard (EPA)
  • DTXSID90144508 Edit this at Wikidata
ECHA InfoCard100.002.726 Edit this at Wikidata
Chemical and physical data
FormulaC8H11N5
Molar mass177.211 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point135–142 °C (275–288 °F)
  • c1ccc(cc1)NC(=N)NC(=N)N
  • InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)
  • Key:CUQCMXFWIMOWRP-UHFFFAOYSA-N

Derivatives edit

  • Phenylbiguanide is used to make amanozine and benfosformin.[citation needed]

References edit

  1. ^ Higgins GA, Joharchi N, Sellers EM (March 1993). "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats". The Journal of Pharmacology and Experimental Therapeutics. Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1440–9. PMID 8450478.
  2. ^ Chen JP, van Praag HM, Gardner EL (March 1991). "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens". Brain Research. Brain Research. 543 (2): 354–7. doi:10.1016/0006-8993(91)90050-6. PMID 1711914. S2CID 37426395.