Phenylmercuric_nitrate Knowpia

Phenylmercuric nitrate
Names
	IUPAC name nitrooxy(phenyl)mercury
Identifiers
CAS Number	55-68-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:136021;
ChemSpider	13854801 ;
ECHA InfoCard	100.000.221
EC Number	200-242-9;
PubChem CID	16682924;
RTECS number	OW8400000;
UNII	CG8692ZN14 ;
UN number	1895
CompTox Dashboard (EPA)	DTXSID6044569 ;
	InChI InChI=1S/C6H5.Hg.NO3/c1-2-4-6-5-3-1;;2-1(3)4/h1-5H;;/q;+1;-1 Key: PDTFCHSETJBPTR-UHFFFAOYSA-N;
	SMILES C1=CC=C(C=C1)[Hg]O[N+](=O)[O-];
Properties
Chemical formula	C6H5HgNO3
Molar mass	339.702 g/mol
Melting point	176–186 °C (349–367 °F; 449–459 K)
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Toxic
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H301, H314, H372, H410
Precautionary statements	P260, P264, P270, P273, P280, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P314, P321, P330, P363, P391, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Phenylmercuric nitrate is an organomercury compound with powerful antiseptic and antifungal effects.^[1] It was once commonly used as a topical solution for disinfecting wounds, but as with all organomercury compounds it is highly toxic, especially to the kidneys, and is no longer used in this application. However it is still used in low concentrations as a preservative in eye drops for ophthalmic use, making it one of the few organomercury derivatives remaining in current medical use.^[2]

References edit

^ Xu, Y.; He, Y.; Li, X.; Gao, C.; Zhou, L.; Sun, S.; Pang, G. (2013). "Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi". Diagnostic Microbiology and Infectious Disease. 75 (1): 64–7. doi:10.1016/j.diagmicrobio.2012.09.008. PMID 23102555.
^ Kaur, I. P.; Lal, S.; Rana, C.; Kakkar, S.; Singh, H. (2009). "Ocular preservatives: Associated risks and newer options". Cutaneous and Ocular Toxicology. 28 (3): 93–103. doi:10.1080/15569520902995834. PMID 19505226. S2CID 9806996.

[1] Xu, Y.; He, Y.; Li, X.; Gao, C.; Zhou, L.; Sun, S.; Pang, G. (2013). "Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi". Diagnostic Microbiology and Infectious Disease. 75 (1): 64–7. doi:10.1016/j.diagmicrobio.2012.09.008. PMID 23102555.

[2] Kaur, I. P.; Lal, S.; Rana, C.; Kakkar, S.; Singh, H. (2009). "Ocular preservatives: Associated risks and newer options". Cutaneous and Ocular Toxicology. 28 (3): 93–103. doi:10.1080/15569520902995834. PMID 19505226. S2CID 9806996.

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Summary

See also edit

References edit