Photobiotin is a derivative of biotin used as a biochemical tool. It is composed of a biotin group, a linker group, and a photoactivatable aryl azide group.
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IUPAC name
N-{3-[{3-[(4-Azido-2-nitrophenyl)amino]propyl}(methyl)amino]propyl}-5-[(3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
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Other names
Photoprobe biotin, Photoactivatable biotin
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3D model (JSmol)
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ChemSpider |
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PubChem CID
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UNII |
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CompTox Dashboard (EPA)
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Properties | |
C23H35N9O4S | |
Molar mass | 533.65 g·mol−1 |
Appearance | Orange to red powder |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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The photoactivatable group provides nonspecific labeling of proteins, DNA and RNA probes or other molecules. Biotinylation of DNA and RNA with photoactivatable biotin is easier and less expensive than enzymatic methods since the DNA and RNA does not degrade. Photobiotin is most effectively activated by light at 260-475 nm.