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Phytoalexin

Summary

Phytoalexins are antimicrobial substances, some of which are antioxidative as well. They are defined, not by their having any particular chemical structure or character, but by the fact that they are defensively synthesized de novo by plants that produce the compounds rapidly at sites of pathogen infection. In general phytoalexins are broad spectrum inhibitors; they are chemically diverse, and different chemical classes of compounds are characteristic of particular plant taxa. Phytoalexins tend to fall into several chemical classes, including terpenoids, glycosteroids, and alkaloids; however the term applies to any phytochemicals that are induced by microbial infection.

Capsidiol is a phytoalexin produced by certain plants in response to pathogenic attack

Function edit

Phytoalexins are produced in plants to act as toxins to the attacking organism. They may puncture the cell wall, delay maturation, disrupt metabolism or prevent reproduction of the pathogen in question. Their importance in plant defense is indicated by an increase in susceptibility of plant tissue to infection when phytoalexin biosynthesis is inhibited. Mutants incapable of phytoalexin production exhibit more extensive pathogen colonization as compared to wild types. As such, host-specific pathogens capable of degrading phytoalexins are more virulent than those unable to do so.[1]

When a plant cell recognizes particles from damaged cells or particles from the pathogen, the plant launches a two-pronged resistance: a general short-term response and a delayed long-term specific response.[citation needed]

As part of the induced resistance, the short-term response, the plant deploys reactive oxygen species such as superoxide and hydrogen peroxide to kill invading cells. In pathogen interactions, the common short-term response is the hypersensitive response, in which cells surrounding the site of infection are signaled to undergo apoptosis, or programmed cell death, in order to prevent the spread of the pathogen to the rest of the plant.[citation needed]

Long-term resistance, or systemic acquired resistance (SAR), involves communication of the damaged tissue with the rest of the plant using plant hormones such as jasmonic acid, ethylene, abscisic acid, or salicylic acid. The reception of the signal leads to global changes within the plant, which induce expression of genes that protect from further pathogen intrusion, including enzymes involved in the production of phytoalexins. Often, if jasmonates or ethylene (both gaseous hormones) are released from the wounded tissue, neighboring plants also manufacture phytoalexins in response. For herbivores, common vectors for plant diseases, these and other wound response aromatics seem to act as a warning that the plant is no longer edible.[citation needed] Also, in accordance with the old adage, "an enemy of my enemy is my friend", the aromatics may alert natural enemies of the plant invaders to the presence thereof.

Recent research edit

Allixin (3-hydroxy-5-methoxy-6-methyl-2-pentyl-4H-pyran-4-one), a non-sulfur-containing compound having a γ-pyrone skeletal structure, was the first compound isolated from garlic as a phytoalexin, a product induced in plants by continuous stress.[2] This compound has been shown to have unique biological properties, such as anti-oxidative effects,[2] anti-microbial effects,[2] anti-tumor promoting effects,[3] inhibition of aflatoxin B2 DNA binding,[4] and neurotrophic effects.[4] Allixin showed an anti-tumor promoting effect in vivo, inhibiting skin tumor formation by TPA in DMBA initiated mice.[3] Herein, allixin and/or its analogs may be expected to be useful compounds for cancer prevention or chemotherapy agents for other diseases.[citation needed]

Role of natural phenols in the plant defense against fungal pathogens edit

Polyphenols, especially isoflavonoids and related substances, play a role in the plant defense against fungal and other microbial pathogens.

In Vitis vinifera grape, trans-resveratrol is a phytoalexin produced against the growth of fungal pathogens such as Botrytis cinerea[5] and delta-viniferin is another grapevine phytoalexin produced following fungal infection by Plasmopara viticola.[6] Pinosylvin is a pre-infectious stilbenoid toxin (i.e. synthesized prior to infection), contrary to phytoalexins which are synthesized during infection. It is present in the heartwood of Pinaceae.[7] It is a fungitoxin protecting the wood from fungal infection.[8]

Sakuranetin is a flavanone, a type of flavonoid. It can be found in Polymnia fruticosa[9] and rice, where it acts as a phytoalexin against spore germination of Pyricularia oryzae.[10] In Sorghum, the SbF3'H2 gene, encoding a flavonoid 3'-hydroxylase, seems to be expressed in pathogen-specific 3-deoxyanthocyanidin phytoalexin synthesis,[11] for example in Sorghum-Colletotrichum interactions.[12]

6-Methoxymellein is a dihydroisocoumarin and a phytoalexin induced in carrot slices by UV-C,[13] that allows resistance to Botrytis cinerea[14] and other microorganisms.[15]

Danielone is a phytoalexin found in the papaya fruit. This compound showed high antifungal activity against Colletotrichum gloesporioides, a pathogenic fungus of papaya.[16]

Stilbenes are produced in Eucalyptus sideroxylon in case of pathogen attacks. Such compounds can be implied in the hypersensitive response of plants. High levels of polyphenols in some woods can explain their natural preservation against rot.[17]

Avenanthramides are phytoalexins produced by Avena sativa in its response to Puccinia coronata var. avenae f. sp. avenae, the oat crown rust.[18][19] (Avenanthramides were formerly called avenalumins.)[20]

See also edit

References edit

  1. ^ Glazebrook, J; Ausubel, F M (1994). "Isolation of phytoalexin-deficient mutants of Arabidopsis thaliana and characterization of their interactions with bacterial pathogens". PNAS. 91 (19): 8955–8959. Bibcode:1994PNAS...91.8955G. doi:10.1073/pnas.91.19.8955. PMC 44725. PMID 8090752.
  2. ^ a b c Kodera Y, Matuura H, Yoshida S, Sumida T, Itakura Y, Fuwa T, Nishino H (1989). "Allixin, a stress compound from garlic". Chem. Pharm. Bull. 37 (6): 1656–1658. doi:10.1248/cpb.37.1656.
  3. ^ a b Nishino H, Nishino A, Takayama J, Iwashima A, Itakura Y, Kodera Y, Matsuura H, Fuwa T (1990). "Antitumor promoting activity of allixin, a stress compound produced by garlic". Cancer J. 3: 20–21.
  4. ^ a b Yamasaki T.; Teel R. W.; Lau B. H. S. (1991). "Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1". Cancer Lett. 59 (2): 89–94. doi:10.1016/0304-3835(91)90171-D. PMID 1909211.
  5. ^ F. Favaron; M. Lucchetta; S. Odorizzi; A.T. Pais da Cunha; L. Sella (2009). "The role of grape polyphenols on trans-resveratrol activity against Botrytis cinerea and of fungal laccase on the solubility of putative grape PR proteins" (PDF). Journal of Plant Pathology. 91 (3): 579–588. Retrieved 2011-01-22.
  6. ^ Timperio, Anna Maria; d’Alessandro, Angelo; Fagioni, Marco; Magro, Paolo; Zolla, Lello (2012). "Production of the phytoalexins trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions". Plant Physiology and Biochemistry. 50 (1): 65–71. doi:10.1016/j.plaphy.2011.07.008. PMID 21821423.
  7. ^ Hovelstad, Hanne; Leirset, Ingebjorg; Oyaas, Karin; Fiksdahl, Anne (2006). "Screening Analyses of Pinosylvin Stilbenes, Resin Acids and Lignans in Norwegian Conifers". Molecules. 11 (1): 103–14. doi:10.3390/11010103. PMC 6148674. PMID 17962750.
  8. ^ Lee, S.K.; Lee, H.J.; Min, H.Y.; Park, E.J.; Lee, K.M.; Ahn, Y.H.; Cho, Y.J.; Pyee, J.H. (2005). "Antibacterial and antifungal activity of pinosylvin, a constituent of pine". Fitoterapia. 76 (2): 258–60. doi:10.1016/j.fitote.2004.12.004. PMID 15752644.
  9. ^ "Structure and Data for Sakuranetin (NSC 407228)". home.ncifcrf.gov. Archived from the original on 2018-12-03. Retrieved 2012-04-13.
  10. ^ Kodama, Osamu; Miyakawa, Junichi; Akatsuka, Tadami; Kiyosawa, Shigehisa (1992). "Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves". Phytochemistry. 31 (11): 3807–3809. Bibcode:1992PChem..31.3807K. doi:10.1016/S0031-9422(00)97532-0.
  11. ^ Chun-Hat Shih; Ivan K. Chu; Wing Kin Yip; Clive Lo (2006). "Differential Expression of Two Flavonoid 3'-Hydroxylase cDNAs Involved in Biosynthesis of Anthocyanin Pigments and 3-Deoxyanthocyanidin Phytoalexins in Sorghum". Plant and Cell Physiology. 47 (10): 1412–1419. doi:10.1093/pcp/pcl003. PMID 16943219.
  12. ^ Chopra, Surinder; Gaffoor, Iffa; Ibraheem, Farag. "Biosynthesis and regulation of 3-deoxyanthocyanidin phytoalexins induced during Sorghum-Colletotrichum interaction: Heterologous expression in maize". Archived from the original on 2011-07-25.
  13. ^ Mercier, J.; Arul, J.; Ponnampalam, R.; Boulet, M. (1993). "Induction of 6-Methoxymellein and Resistance to Storage Pathogens in Carrot Slices by UV-C". Journal of Phytopathology. 137: 44–54. doi:10.1111/j.1439-0434.1993.tb01324.x.
  14. ^ Hoffman, R.; Heale, J.B. (1987). "Cell death, 6-methoxymellein accumulation, and induced resistance to Botrytis cinerea in carrot root slices". Physiological and Molecular Plant Pathology. 30: 67–75. doi:10.1016/0885-5765(87)90083-X.
  15. ^ Kurosaki, Fumiya; Nishi, Arasuke (1983). "Isolation and antimicrobial activity of the phytoalexin 6-methoxymellein from cultured carrot cells". Phytochemistry. 22 (3): 669. Bibcode:1983PChem..22..669K. doi:10.1016/S0031-9422(00)86959-9.
  16. ^ Echeverri, Fernando; Torres, Fernando; Quiñones, Winston; Cardona, Gloria; Archbold, Rosendo; Roldan, Javier; Brito, Ivan; Luis, Javier G.; Lahlou, El-Hassane (1997). "Danielone, a phytoalexin from papaya fruit". Phytochemistry. 44 (2): 255–256. Bibcode:1997PChem..44..255E. doi:10.1016/S0031-9422(96)00418-9. PMID 9004541.
  17. ^ Hart, John H.; Hillis, W. E. (1974). "Inhibition of wood-rotting fungi by stilbenes and other polyphenols in Eucalyptus sideroxylon". Phytopathology. 64 (7): 939–48. doi:10.1094/Phyto-64-939.
  18. ^ Mayama, S.; Bordin, A.P.A.; Morikawa, T.; Tanpo, H.; Kato, H. (1995). "Association of avenalumin accumulation with co-segregation of victorin sensitivity and crown rust resistance in oat lines carrying the Pc-2 gene". Physiological and Molecular Plant Pathology. 46 (4): 263–274. doi:10.1006/pmpp.1995.1021. S2CID 82948086.
  19. ^ Mayama, S.; Matsuura, Y.; Iida, H.; Tani, T. (1982). "The role of avenalumin in the resistance of oat to crown rust, Puccinia coronata f. sp. avenae". Physiological Plant Pathology. 20 (2): 189–199. doi:10.1016/0048-4059(82)90084-4.
  20. ^ Hammerschmidt, Ray (1999). "Phytoalexins: What Have We Learned After 60 Years?". Annual Review of Phytopathology. 37 (1): 285–306. doi:10.1146/annurev.phyto.37.1.285. PMID 11701825.

Further reading edit

  • Moriguchi, Toru; Matsuura, Hiromichi; Itakura, Yoichi; Katsuki, Hiroshi; Saito, Hiroshi; Nishiyama, Nobuyoshi (1997). "Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity". Life Sciences. 61 (14): 1413–1420. doi:10.1016/S0024-3205(97)00687-5. PMID 9335231.
  • Kodera, Yukihiro; Ichikawa, Makoto; Yoshida, Jiro; Kashimoto, Naoki; Uda, Naoto; Sumioka, Isao; Ide, Nagatoshi; Ono, Kazuhisa (2002). "Pharmacokinetic Study of Allixin, a Phytoalexin Produced by Garlic". Chemical and Pharmaceutical Bulletin. 50 (3): 354–363. doi:10.1248/cpb.50.354. PMID 11911198.

External links edit

  • Signals Regulating Multiple Responses to Wounding and Herbivores Guy L. de Bruxelles and Michael R Roberts
  • The Myriad Plant Responses to Herbivores Linda L. Walling
  • The Chemical Defenses of Higher Plants Gerald A. Rosenthal
  • Induced Systemic Resistance (ISR) Against Pathogens in the Context of Induced Plant Defences Martin Heil
  • Notes from the Underground Donald R. Strong and Donald A. Phillips
  • Relationships Among Plants, Insect Herbivores, Pathogens, and Parasitoids Expressed by Secondary Metabolites Loretta L. Mannix

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