Picotamide Knowpia

Picotamide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	B01AC03 (WHO) ;
Identifiers
	IUPAC name 4-methoxy-N,N'-bis(pyridin-3-ylmethyl)isophthalamide;
CAS Number	32828-81-2 ; 80530-63-8 (monohydrate);
PubChem CID	4814;
ChemSpider	4649 ;
UNII	654G2VCI4Q;
CompTox Dashboard (EPA)	DTXSID40186498 ;
ECHA InfoCard	100.046.572
Chemical and physical data
Formula	C21H20N4O3
Molar mass	376.416 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NCc1cccnc1)c3cc(C(=O)NCc2cccnc2)c(OC)cc3;
	InChI InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27) ; Key:KYWCWBXGRWWINE-UHFFFAOYSA-N ;
	(verify)

Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.^[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.^[2]

References edit

^ Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes". European Journal of Pharmacology. 355 (1): 77–83. doi:10.1016/S0014-2999(98)00467-1. PMID 9754941.
^ Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (February 2014). "Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation". Journal of Thrombosis and Haemostasis. 12 (2): 126–137. doi:10.1111/jth.12472. PMID 24298905.