Porokeratosis is a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the stratum corneum with a thin or absent granular layer.[1]: 532
Porokeratosis | |
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A porokeratosis lesion in a patient with disseminated superficial actinic porokeratosis. | |
Specialty | Pediatrics, dermatology |
Porokeratosis may be divided into the following clinical types:[1]: 532
Linear porokeratosis has been associated with mutations in the PMVK and MVD genes.[7] The PMVK gene encodes the enzyme phosphomevalonate kinase and the MVD gene encodes the enzyme diphosphomevalonate decarboxylase.
Porokeratosis has a characteristic histomorphologic feature known as a cornoid lamella.
Dermabrasion