Most people who experience traumatic events do not develop PTSD. People who experience interpersonal violence such as rape, other sexual assaults, being kidnapped, stalking, physical abuse by an intimate partner, and incest or other forms of childhood sexual abuse are more likely to develop PTSD than those who experience non-assault based trauma, such as accidents and natural disasters. Those who experience prolonged trauma, such as slavery, concentration camps, or chronic domestic abuse, may develop complex post-traumatic stress disorder (C-PTSD). C-PTSD is similar to PTSD but has a distinct effect on a person's emotional regulation and core identity.
Prevention may be possible when counselling is targeted at those with early symptoms but is not effective when provided to all trauma-exposed individuals whether or not symptoms are present. The main treatments for people with PTSD are counselling (psychotherapy) and medication.Antidepressants of the SSRI or SNRI type are the first-line medications used for PTSD and are moderately beneficial for about half of people. Benefits from medication are less than those seen with counselling. It is not known whether using medications and counselling together has greater benefit than either method separately. Medications, other than some SSRIs or SNRIs, do not have enough evidence to support their use and, in the case of benzodiazepines, may worsen outcomes.
In the United States, about 3.5% of adults have PTSD in a given year, and 9% of people develop it at some point in their life. In much of the rest of the world, rates during a given year are between 0.5% and 1%. Higher rates may occur in regions of armed conflict. It is more common in women than men.
Symptoms of PTSD generally begin within the first three months after the inciting traumatic event, but may not begin until years later. In the typical case, the individual with PTSD persistently avoids either trauma-related thoughts and emotions or discussion of the traumatic even and may even have amnesia of the event. However, the event is commonly relived by the individual through intrusive, recurrent recollections, dissociative episodes of reliving the trauma ("flashbacks"), and nightmares (50 to 70%). While it is common to have symptoms after any traumatic event, these must persist to a sufficient degree (i.e., causing dysfunction in life or clinical levels of distress) for longer than one month after the trauma to be classified as PTSD (clinically significant dysfunction or distress for less than one month after the trauma may be acute stress disorder). Some following a traumatic event experience post-traumatic growth.
Associated medical conditions
Trauma survivors often develop depression, anxiety disorders, and mood disorders in addition to PTSD.
Substance use disorder, such as alcohol use disorder, commonly co-occur with PTSD. Recovery from post-traumatic stress disorder or other anxiety disorders may be hindered, or the condition worsened, when substance use disorders are comorbid with PTSD. Resolving these problems can bring about improvement in an individual's mental health status and anxiety levels.
In children and adolescents, there is a strong association between emotional regulation difficulties (e.g. mood swings, anger outbursts, temper tantrums) and post-traumatic stress symptoms, independent of age, gender, or type of trauma.
Persons considered at risk include combat military personnel, victims of natural disasters, concentration camp survivors, and victims of violent crime. Persons employed in occupations that expose them to violence (such as soldiers) or disasters (such as emergency service workers) are also at risk. Other occupations that are at higher risk include police officers, firefighters, ambulance personnel, health care professionals, train drivers, divers, journalists, and sailors, in addition to people who work at banks, post offices or in stores.
PTSD has been associated with a wide range of traumatic events. The risk of developing PTSD after a traumatic event varies by trauma type and is highest following exposure to sexual violence (11.4%), particularly rape (19.0%). Men are more likely to experience a traumatic event (of any type), but women are more likely to experience the kind of high-impact traumatic event that can lead to PTSD, such as interpersonal violence and sexual assault.
Motor vehicle collision survivors, both children and adults, are at an increased risk of PTSD. Globally, about 2.6% of adults are diagnosed with PTSD following a non-life threatening traffic accident, and a similar proportion of children develop PTSD. Risk of PTSD almost doubles to 4.6% for life-threatening auto accidents. Females were more likely to be diagnosed with PTSD following a road traffic accident, whether the accident occurred during childhood or adulthood.
Post-traumatic stress reactions have been studied in children and adolescents. The rate of PTSD might be lower in children than adults, but in the absence of therapy, symptoms may continue for decades. One estimate suggests that the proportion of children and adolescents having PTSD in a non-wartorn population in a developed country may be 1% compared to 1.5% to 3% of adults. On average, 16% of children exposed to a traumatic event develop PTSD, varying according to type of exposure and gender. Similar to the adult population, risk factors for PTSD in children include: female gender, exposure to disasters (natural or manmade), negative coping behaviours, and/or lacking proper social support systems.
Predictor models have consistently found that childhood trauma, chronic adversity, neurobiological differences, and familial stressors are associated with risk for PTSD after a traumatic event in adulthood. It has been difficult to find consistently aspects of the events that predict, but peritraumatic dissociation has been a fairly consistent predictive indicator of the development of PTSD. Proximity to, duration of, and severity of the trauma make an impact. It has been speculated that interpersonal traumas cause more problems than impersonal ones, but this is controversial. The risk of developing PTSD is increased in individuals who are exposed to physical abuse, physical assault, or kidnapping. Women who experience physical violence are more likely to develop PTSD than men.
Intimate partner violence
An individual that has been exposed to domestic violence is predisposed to the development of PTSD. However, being exposed to a traumatic experience does not automatically indicate that an individual will develop PTSD. There is a strong association between the development of PTSD in mothers that experienced domestic violence during the perinatal period of their pregnancy.
Those who have experienced sexual assault or rape may develop symptoms of PTSD. PTSD symptoms include re-experiencing the assault, avoiding things associated with the assault, numbness, and increased anxiety and an increased startle response. The likelihood of sustained symptoms of PTSD is higher if the rapist confined or restrained the person, if the person being raped believed the rapist would kill them, the person who was raped was very young or very old, and if the rapist was someone they knew. The likelihood of sustained severe symptoms is also higher if people around the survivor ignore (or are ignorant of) the rape or blame the rape survivor.
Military service is a risk factor for developing PTSD. Around 78% of people exposed to combat do not develop PTSD; in about 25% of military personnel who develop PTSD, its appearance is delayed.
Refugees are also at an increased risk for PTSD due to their exposure to war, hardships, and traumatic events. The rates for PTSD within refugee populations range from 4% to 86%. While the stresses of war affect everyone involved, displaced persons have been shown to be more so than others.
Challenges related to the overall psychosocial well-being of refugees are complex and individually nuanced. Refugees have reduced levels of well-being and a high rates of mental distress due to past and ongoing trauma. Groups that are particularly affected and whose needs often remain unmet are women, older people and unaccompanied minors. Post-traumatic stress and depression in refugee populations also tend to affect their educational success.
Unexpected death of a loved one
Sudden, unexpected death of a loved one is the most common traumatic event type reported in cross-national studies. However, the majority of people who experience this type of event will not develop PTSD. An analysis from the WHO World Mental Health Surveys found a 5.2% risk of developing PTSD after learning of the unexpected death of a loved one. Because of the high prevalence of this type of traumatic event, unexpected death of a loved one accounts for approximately 20% of PTSD cases worldwide.
Medical conditions associated with an increased risk of PTSD include cancer, heart attack, and stroke. 22% of cancer survivors present with lifelong PTSD like symptoms. Intensive-care unit (ICU) hospitalization is also a risk factor for PTSD. Some women experience PTSD from their experiences related to breast cancer and mastectomy. Loved ones of those who experience life-threatening illnesses are also at risk for developing PTSD, such as parents of child with chronic illnesses.
Women who experience miscarriage are at risk of PTSD. Those who experience subsequent miscarriages have an increased risk of PTSD compared to those experiencing only one. PTSD can also occur after childbirth and the risk increases if a woman has experienced trauma prior to the pregnancy. Prevalence of PTSD following normal childbirth (that is, excluding stillbirth or major complications) is estimated to be between 2.8 and 5.6% at six weeks postpartum, with rates dropping to 1.5% at six months postpartum. Symptoms of PTSD are common following childbirth, with prevalence of 24-30.1% at six weeks, dropping to 13.6% at six months. Emergency childbirth is also associated with PTSD.
There is evidence that susceptibility to PTSD is hereditary. Approximately 30% of the variance in PTSD is caused from genetics alone. For twin pairs exposed to combat in Vietnam, having a monozygotic (identical) twin with PTSD was associated with an increased risk of the co-twin's having PTSD compared to twins that were dizygotic (non-identical twins). Women with a smaller hippocampus might be more likely to develop PTSD following a traumatic event based on preliminary findings. Research has also found that PTSD shares many genetic influences common to other psychiatric disorders. Panic and generalized anxiety disorders and PTSD share 60% of the same genetic variance. Alcohol, nicotine, and drug dependence share greater than 40% genetic similarities.
Several biological indicators have been identified that are related to later PTSD development. Heightened startle responses and, with only preliminary results, a smaller hippocampal volume have been identified as possible biomarkers for heightened risk of developing PTSD. Additionally, one study found that soldiers whose leukocytes had greater numbers of glucocorticoid receptors were more prone to developing PTSD after experiencing trauma.
PTSD symptoms may result when a traumatic event causes an over-reactive adrenaline response, which creates deep neurological patterns in the brain. These patterns can persist long after the event that triggered the fear, making an individual hyper-responsive to future fearful situations. During traumatic experiences, the high levels of stress hormones secreted suppress hypothalamic activity that may be a major factor toward the development of PTSD.
The maintenance of fear has been shown to include the HPA axis, the locus coeruleus-noradrenergic systems, and the connections between the limbic system and frontal cortex. The HPA axis that coordinates the hormonal response to stress, which activates the LC-noradrenergic system, is implicated in the over-consolidation of memories that occurs in the aftermath of trauma. This over-consolidation increases the likelihood of one's developing PTSD. The amygdala is responsible for threat detection and the conditioned and unconditioned fear responses that are carried out as a response to a threat.
The HPA axis is responsible for coordinating the hormonal response to stress. Given the strong cortisol suppression to dexamethasone in PTSD, HPA axis abnormalities are likely predicated on strong negative feedback inhibition of cortisol, itself likely due to an increased sensitivity of glucocorticoid receptors.
PTSD has been hypothesized to be a maladaptive learning pathway to fear response through a hypersensitive, hyperreactive, and hyperresponsive HPA axis.
Low cortisol levels may predispose individuals to PTSD: Following war trauma, Swedish soldiers serving in Bosnia and Herzegovina with low pre-service salivary cortisol levels had a higher risk of reacting with PTSD symptoms, following war trauma, than soldiers with normal pre-service levels. Because cortisol is normally important in restoring homeostasis after the stress response, it is thought that trauma survivors with low cortisol experience a poorly contained—that is, longer and more distressing—response, setting the stage for PTSD.
It is thought that the locus coeruleus-noradrenergic system mediates the over-consolidation of fear memory. High levels of cortisol reduce noradrenergic activity, and because people with PTSD tend to have reduced levels of cortisol, it has been proposed that individuals with PTSD cannot regulate the increased noradrenergic response to traumatic stress. Intrusive memories and conditioned fear responses are thought to be a result of the response to associated triggers. Neuropeptide Y (NPY) has been reported to reduce the release of norepinephrine and has been demonstrated to have anxiolytic properties in animal models. Studies have shown people with PTSD demonstrate reduced levels of NPY, possibly indicating their increased anxiety levels.
Other studies indicate that people that suffer from PTSD have chronically low levels of serotonin, which contributes to the commonly associated behavioral symptoms such as anxiety, ruminations, irritability, aggression, suicidality, and impulsivity. Serotonin also contributes to the stabilization of glucocorticoid production.
Several studies described elevated concentrations of the thyroid hormonetriiodothyronine in PTSD. This kind of type 2 allostatic adaptation may contribute to increased sensitivity to catecholamines and other stress mediators.
Hyperresponsiveness in the norepinephrine system can also be caused by continued exposure to high stress. Overactivation of norepinephrine receptors in the prefrontal cortex can be connected to the flashbacks and nightmares frequently experienced by those with PTSD. A decrease in other norepinephrine functions (awareness of the current environment) prevents the memory mechanisms in the brain from processing the experience, and emotions the person is experiencing during a flashback are not associated with the current environment.
There is considerable controversy within the medical community regarding the neurobiology of PTSD. A 2012 review showed no clear relationship between cortisol levels and PTSD. The majority of reports indicate people with PTSD have elevated levels of corticotropin-releasing hormone, lower basal cortisol levels, and enhanced negative feedback suppression of the HPA axis by dexamethasone.
Regions of the brain associated with stress and post-traumatic stress disorder
The amygdala is strongly involved in forming emotional memories, especially fear-related memories. During high stress, the hippocampus, which is associated with placing memories in the correct context of space and time and memory recall, is suppressed. According to one theory this suppression may be the cause of the flashbacks that can affect people with PTSD. When someone with PTSD undergoes stimuli similar to the traumatic event, the body perceives the event as occurring again because the memory was never properly recorded in the person's memory.
The amygdalocentric model of PTSD proposes that the amygdala is very much aroused and insufficiently controlled by the medial prefrontal cortex and the hippocampus, in particular during extinction. This is consistent with an interpretation of PTSD as a syndrome of deficient extinction ability.
The basolateral nucleus (BLA) of the amygdala is responsible for the comparison and development of associations between unconditioned and conditioned responses to stimuli, which results in the fear conditioning present in PTSD. The BLA activates the central nucleus (CeA) of the amygdala, which elaborates the fear response, (including behavioral response to threat and elevated startle response). Descending inhibitory inputs from the medial prefrontal cortex (mPFC) regulate the transmission from the BLA to the CeA, which is hypothesized to play a role in the extinction of conditioned fear responses. While as a whole, amygdala hyperactivity is reported by meta analysis of functional neuroimaging in PTSD, there is a large degree of heterogeniety, more so than in social anxiety disorder or phobic disorder. Comparing dorsal (roughly the CeA) and ventral(roughly the BLA) clusters, hyperactivity is more robust in the ventral cluster, while hypoactivity is evident in the dorsal cluster. The distinction may explain the blunted emotions in PTSD (via desensitization in the CeA) as well as the fear related component.
In a 2007 study Vietnam War combat veterans with PTSD showed a 20% reduction in the volume of their hippocampus compared with veterans having suffered no such symptoms. This finding was not replicated in chronic PTSD patients traumatized at an air show plane crash in 1988 (Ramstein, Germany).
Evidence suggests that endogenous cannabinoid levels are reduced in PTSD, particularly anandamide, and that cannabinoid receptors (CB1) are increased in order to compensate. There appears to be a link between increased CB1 receptor availability in the amygdala and abnormal threat processing and hyperarousal, but not dysphoria, in trauma survivors.
A 2020 study found no evidence for conclusions from prior research that suggested low IQ is a risk factor for developing PTSD.
PTSD can be difficult to diagnose, because of:
the subjective nature of most of the diagnostic criteria (although this is true for many mental disorders);
the potential for over-reporting, e.g., while seeking disability benefits, or when PTSD could be a mitigating factor at criminal sentencing
the potential for under-reporting, e.g., stigma, pride, fear that a PTSD diagnosis might preclude certain employment opportunities;
symptom overlap with other mental disorders such as obsessive compulsive disorder and generalized anxiety disorder;
association with other mental disorders such as major depressive disorder and generalized anxiety disorder;
substance use disorders, which often produce some of the same signs and symptoms as PTSD; and
substance use disorders can increase vulnerability to PTSD or exacerbate PTSD symptoms or both; and
PTSD increases the risk for developing substance use disorders.
the differential expression of symptoms culturally (specifically with respect to avoidance and numbing symptoms, distressing dreams, and somatic symptoms)
There are a number of PTSD screening instruments for adults, such as the PTSD Checklist for DSM-5 (PCL-5) and the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5).
There are also several screening and assessment instruments for use with children and adolescents. These include the Child PTSD Symptom Scale (CPSS), Child Trauma Screening Questionnaire, and UCLA Post-traumatic Stress Disorder Reaction Index for DSM-IV.
In addition, there are also screening and assessment instruments for caregivers of very young children (six years of age and younger). These include the Young Child PTSD Screen, the Young Child PTSD Checklist, and the Diagnostic Infant and Preschool Assessment.
PTSD was classified as an anxiety disorder in the DSM-IV, but has since been reclassified as a "trauma- and stressor-related disorder" in the DSM-5. The DSM-5 diagnostic criteria for PTSD include four symptom clusters: re-experiencing, avoidance, negative alterations in cognition/mood, and alterations in arousal and reactivity.
International classification of diseases
The International Classification of Diseases and Related Health Problems 10 (ICD-10) classifies PTSD under "Reaction to severe stress, and adjustment disorders." The ICD-10 criteria for PTSD include re-experiencing, avoidance, and either increased reactivity or inability to recall certain details related to the event.
The ICD-11 diagnostic description for PTSD contains three components or symptom groups (1) re-experiencing, (2) avoidance, and (3) heightened sense of threat. ICD-11 no longer includes verbal thoughts about the traumatic event as a symptom. There is a predicted lower rate of diagnosed PTSD using ICD-11 compared to ICD10 or DSM-5. ICD-11 also proposes identifying a distinct group with complex post-traumatic stress disorder (CPTSD), who have more often experienced several or sustained traumas and have greater functional impairment than those with PTSD.
A diagnosis of PTSD requires that the person has been exposed to an extreme stressor. Any stressor can result in a diagnosis of adjustment disorder and it is an appropriate diagnosis for a stressor and a symptom pattern that does not meet the criteria for PTSD.
The symptom pattern for acute stress disorder must occur and be resolved within four weeks of the trauma. If it lasts longer, and the symptom pattern fits that characteristic of PTSD, the diagnosis may be changed.
In extreme cases of prolonged, repeated traumatization where there is no viable chance of escape, survivors may develop complex post-traumatic stress disorder. This occurs as a result of layers of trauma rather than a single traumatic event, and includes additional symptomatology, such as the loss of a coherent sense of self.
Trauma-exposed individuals often receive treatment called psychological debriefing in an effort to prevent PTSD, which consists of interviews that are meant to allow individuals to directly confront the event and share their feelings with the counselor and to help structure their memories of the event. However, several meta-analyses find that psychological debriefing is unhelpful and is potentially harmful. This is true for both single-session debriefing and multiple session interventions. As of 2017 the American Psychological Association assessed psychological debriefing as No Research Support/Treatment is Potentially Harmful.
Risk-targeted interventions are those that attempt to mitigate specific formative information or events. It can target modeling normal behaviors, instruction on a task, or giving information on the event.
Reviews of studies have found that combination therapy (psychological and pharmacotherapy) is no more effective than psychological therapy alone.
A 2019 Cochrane review evaluated couples and family therapies compared to no care and individual and group therapies for the treatment of PTSD. There were too few studies on couples therapies to determine if substantive benefits were derived but preliminary RCTs suggested that couples therapies may be beneficial for reducing PTSD symptoms.
A meta-analytic comparison of EMDR and cognitive behavioral therapy (CBT) found both protocols indistinguishable in terms of effectiveness in treating PTSD; however, "the contribution of the eye movement component in EMDR to treatment outcome" is unclear. A meta-analysis in children and adolescents also found that EMDR was as efficacious as CBT.
Children with PTSD are far more likely to pursue treatment at school (because of its proximity and ease) than at a free clinic.
Cognitive behavioral therapy
The diagram depicts how emotions, thoughts, and behaviors all influence each other. The triangle in the middle represents CBT's tenet that all humans' core beliefs can be summed up in three categories: self, others, future.
CBT seeks to change the way a person feels and acts by changing the patterns of thinking or behavior, or both, responsible for negative emotions. Results from a 2018 systematic review found high strength of evidence that supports CBT-exposure therapy efficacious for a reduction in PTSD and depression symptoms, as well as the loss of PTSD diagnosis. CBT has been proven to be an effective treatment for PTSD and is currently considered the standard of care for PTSD by the United States Department of Defense. In CBT, individuals learn to identify thoughts that make them feel afraid or upset and replace them with less distressing thoughts. The goal is to understand how certain thoughts about events cause PTSD-related stress. The provision of CBT in an Internet-based format has also been studied in a 2018 Cochrane review. This review did find similar beneficial effects for Internet-based settings as in face-to-face but the quality of the evidence was low due to the small number of trials reviewed.
Exposure therapy is a type of cognitive behavioral therapy that involves assisting trauma survivors to re-experience distressing trauma-related memories and reminders in order to facilitate habituation and successful emotional processing of the trauma memory. Most exposure therapy programs include both imaginal confrontation with the traumatic memories and real-life exposure to trauma reminders; this therapy modality is well supported by clinical evidence. The success of exposure-based therapies has raised the question of whether exposure is a necessary ingredient in the treatment of PTSD. Some organizations[which?] have endorsed the need for exposure. The U.S. Department of Veterans Affairs has been actively training mental health treatment staff in prolonged exposure therapy and Cognitive Processing Therapy in an effort to better treat U.S. veterans with PTSD.
Recent research on contextually based third-generation behavior therapies suggests that they may produce results comparable to some of the better validated therapies. Many of these therapy methods have a significant element of exposure and have demonstrated success in treating the primary problems of PTSD and co-occurring depressive symptoms.
Eye movement desensitization and reprocessing
Eye movement desensitization and reprocessing (EMDR) is a form of psychotherapy developed and studied by Francine Shapiro. She had noticed that, when she was thinking about disturbing memories herself, her eyes were moving rapidly. When she brought her eye movements under control while thinking, the thoughts were less distressing.
In 2002, Shapiro and Maxfield published a theory of why this might work, called adaptive information processing. This theory proposes that eye movement can be used to facilitate emotional processing of memories, changing the person's memory to attend to more adaptive information. The therapist initiates voluntary rapid eye movements while the person focuses on memories, feelings or thoughts about a particular trauma. The therapists uses hand movements to get the person to move their eyes backward and forward, but hand-tapping or tones can also be used. EMDR closely resembles cognitive behavior therapy as it combines exposure (re-visiting the traumatic event), working on cognitive processes and relaxation/self-monitoring. However, exposure by way of being asked to think about the experience rather than talk about it has been highlighted as one of the more important distinguishing elements of EMDR.
There have been several small controlled trials of four to eight weeks of EMDR in adults as well as children and adolescents. There is moderate strength of evidence to support the efficacy of EMDR "for reduction in PTSD symptoms, loss of diagnosis, and reduction in depressive symptoms" according to a 2018 systematic review update. EMDR reduced PTSD symptoms enough in the short term that one in two adults no longer met the criteria for PTSD, but the number of people involved in these trials was small and thus results should be interpreted with caution pending further research. There was not enough evidence to know whether or not EMDR could eliminate PTSD in adults. In children and adolescents, a recent meta-analysis of randomized controlled trials using MetaNSUE to avoid biases related to missing information found that EMDR was at least as efficacious as CBT, and superior to waitlist or placebo. There was some evidence that EMDR might prevent depression. There were no studies comparing EMDR to other psychological treatments or to medication. Adverse effects were largely unstudied. The benefits were greater for women with a history of sexual assault compared with people who had experienced other types of traumatizing events (such as accidents, physical assaults and war). There is a small amount of evidence that EMDR may improve re-experiencing symptoms in children and adolescents, but EMDR has not been shown to improve other PTSD symptoms, anxiety, or depression.
The eye movement component of the therapy may not be critical for benefit. As there has been no major, high quality randomized trial of EMDR with eye movements versus EMDR without eye movements, the controversy over effectiveness is likely to continue. Authors of a meta-analysis published in 2013 stated, "We found that people treated with eye movement therapy had greater improvement in their symptoms of post-traumatic stress disorder than people given therapy without eye movements.... Secondly we found that that in laboratory studies the evidence concludes that thinking of upsetting memories and simultaneously doing a task that facilitates eye movements reduces the vividness and distress associated with the upsetting memories."
Other approaches, in particular involving social supports, may also be important. An open trial of interpersonal psychotherapy reported high rates of remission from PTSD symptoms without using exposure. A current, NIMH-funded trial in New York City is now (and into 2013) comparing interpersonal psychotherapy, prolonged exposure therapy, and relaxation therapy.[full citation needed]
While many medications do not have enough evidence to support their use, four (sertraline, fluoxetine, paroxetine, and venlafaxine) have been shown to have a small to modest benefit over placebo. With many medications, residual PTSD symptoms following treatment is the rule rather than the exception.
Benzodiazepines are not recommended for the treatment of PTSD due to a lack of evidence of benefit and risk of worsening PTSD symptoms. Some authors believe that the use of benzodiazepines is contraindicated for acute stress, as this group of drugs can cause dissociation. Nevertheless, some use benzodiazepines with caution for short-term anxiety and insomnia. While benzodiazepines can alleviate acute anxiety, there is no consistent evidence that they can stop the development of PTSD and may actually increase the risk of developing PTSD 2–5 times. Additionally, benzodiazepines may reduce the effectiveness of psychotherapeutic interventions, and there is some evidence that benzodiazepines may actually contribute to the development and chronification of PTSD. For those who already have PTSD, benzodiazepines may worsen and prolong the course of illness, by worsening psychotherapy outcomes, and causing or exacerbating aggression, depression (including suicidality), and substance use. Drawbacks include the risk of developing a benzodiazepine dependence, tolerance (i.e., short-term benefits wearing off with time), and withdrawal syndrome; additionally, individuals with PTSD (even those without a history of alcohol or drug misuse) are at an increased risk of abusing benzodiazepines. Due to a number of other treatments with greater efficacy for PTSD and less risks (e.g., prolonged exposure, cognitive processing therapy, eye movement desensitization and reprocessing, cognitive restructuring therapy, trauma-focused cognitive behavioral therapy, brief eclectic psychotherapy, narrative therapy, stress inoculation training, serotonergic antidepressants, adrenergic inhibitors, antipsychotics, and even anticonvulsants), benzodiazepines should be considered relatively contraindicated until all other treatment options are exhausted. For those who argue that benzodiazepines should be used sooner in the most severe cases, the adverse risk of disinhibition (associated with suicidality, aggression and crimes) and clinical risks of delaying or inhibiting definitive efficacious treatments, make other alternative treatments preferable (e.g., inpatient, residential, partial hospitalization, intensive outpatient, dialectic behavior therapy; and other fast-acting sedating medications such as trazodone, mirtazapine, amitripytline, doxepin, prazosin, propranolol, guanfacine, clonidine, quetiapine, olanzapine, valproate, gabapentin).
Prazosin, an alpha-1 adrenergic antagonist, has been used in veterans with PTSD to reduce nightmares. Studies show variability in the symptom improvement, appropriate dosages, and efficacy in this population.
Glucocorticoids may be useful for short-term therapy to protect against neurodegeneration caused by the extended stress response that characterizes PTSD, but long-term use may actually promote neurodegeneration.
Cannabis is not recommended as a treatment for PTSD because scientific evidence does not currently exist demonstrating treatment efficacy for cannabinoids.[b] However, use of cannabis or derived products is widespread among U.S. veterans with PTSD.
The cannabinoidnabilone is sometimes used for nightmares in PTSD. Although some short-term benefit was shown, adverse effects are common and it has not been adequately studied to determine efficacy. An increasing number of states permit and have legalized the use of medical cannabis for the treatment of PTSD.
Exercise, sport and physical activity
Physical activity can influence people's psychological and physical health. The U.S. National Center for PTSD recommends moderate exercise as a way to distract from disturbing emotions, build self-esteem and increase feelings of being in control again. They recommend a discussion with a doctor before starting an exercise program.
Play therapy for children
Play is thought to help children link their inner thoughts with their outer world, connecting real experiences with abstract thought. Repetitive play can also be one way a child relives traumatic events, and that can be a symptom of trauma in a child or young person. Although it is commonly used, there have not been enough studies comparing outcomes in groups of children receiving and not receiving play therapy, so the effects of play therapy are not yet understood.
In 2020, the United States Food and Drug Administration granted marketing approval for an Apple Watch app call NightWare. The app aims to improve sleep for people suffering from PTSD-related nightmares, by vibrating when it detects a nightmare in progress based on monitoring heart rate and body movement.
There is debate over the rates of PTSD found in populations, but, despite changes in diagnosis and the criteria used to define PTSD between 1997 and 2013, epidemiological rates have not changed significantly. Most of the current reliable data regarding the epidemiology of PTSD is based on DSM-IV criteria, as the DSM-5 was not introduced until 2013.
The United Nations' World Health Organization publishes estimates of PTSD impact for each of its member states; the latest data available are for 2004. Considering only the 25 most populated countries ranked by overall age-standardizedDisability-Adjusted Life Year (DALY) rate, the top half of the ranked list is dominated by Asian/Pacific countries, the US, and Egypt. Ranking the countries by the male-only or female-only rates produces much the same result, but with less meaningfulness, as the score range in the single-sex rankings is much-reduced (4 for women, 3 for men, as compared with 14 for the overall score range), suggesting that the differences between female and male rates, within each country, is what drives the distinctions between the countries.
As of 2017, the cross-national lifetime prevalence of PTSD was 3.9%, based on a survey were 5.6% had been exposed to trauma. The primary factor impacting treatment-seeking behavior, which can help to mitigate PTSD development after trauma was income, while being younger, female, and having less social status (less education, lower individual income, and being unemployed) were all factors associated with less treatment-seeking behaviour.
The National Comorbidity Survey Replication has estimated that the lifetime prevalence of PTSD among adult Americans is 6.8%, with women (9.7%) more than twice as likely as men (3.6%) to have PTSD at some point in their lives. More than 60% of men and more than 60% of women experience at least one traumatic event in their life. The most frequently reported traumatic events by men are rape, combat, and childhood neglect or physical abuse. Women most frequently report instances of rape, sexual molestation, physical attack, being threatened with a weapon and childhood physical abuse. 88% of men and 79% of women with lifetime PTSD have at least one comorbid psychiatric disorder. Major depressive disorder, 48% of men and 49% of women, and lifetime alcohol use disorder or dependence, 51.9% of men and 27.9% of women, are the most common comorbid disorders.
The United States Department of Veterans Affairs estimates that 830,000 Vietnam War veterans suffered symptoms of PTSD. The National Vietnam Veterans' Readjustment Study (NVVRS) found 15% of male and 9% of female Vietnam veterans had PTSD at the time of the study. Life-time prevalence of PTSD was 31% for males and 27% for females. In a reanalysis of the NVVRS data, along with analysis of the data from the Matsunaga Vietnam Veterans Project, Schnurr, Lunney, Sengupta, and Waelde found that, contrary to the initial analysis of the NVVRS data, a large majority of Vietnam veterans suffered from PTSD symptoms (but not the disorder itself). Four out of five reported recent symptoms when interviewed 20–25 years after Vietnam.
A 2011 study from Georgia State University and San Diego State University found that rates of PTSD diagnosis increased significantly when troops were stationed in combat zones, had tours of longer than a year, experienced combat, or were injured. Military personnel serving in combat zones were 12.1 percentage points more likely to receive a PTSD diagnosis than their active-duty counterparts in non-combat zones. Those serving more than 12 months in a combat zone were 14.3 percentage points more likely to be diagnosed with PTSD than those having served less than one year. Experiencing an enemy firefight was associated with an 18.3 percentage point increase in the probability of PTSD, while being wounded or injured in combat was associated with a 23.9 percentage point increase in the likelihood of a PTSD diagnosis. For the 2.16 million U.S. troops deployed in combat zones between 2001 and 2010, the total estimated two-year costs of treatment for combat-related PTSD are between $1.54 billion and $2.69 billion.
As of 2013, rates of PTSD have been estimated at up to 20% for veterans returning from Iraq and Afghanistan. As of 2013 13% of veterans returning from Iraq were unemployed.
The September 11 attacks took the lives of nearly 3,000 people, leaving 6,000 injured.First responders (police, firefighters, and emergency medical technicians), sanitation workers, and volunteers were all involved in the recovery efforts. The prevalence of probable PTSD in these highly exposed populations was estimated across several studies using in-person, telephone, and online interviews and questionnaires. Overall prevalence of PTSD was highest immediately following the attacks and decreased over time. However, disparities were found among the different types of recovery workers. The rate of probable PTSD for first responders was lowest directly after the attacks and increased from ranges of 4.8-7.8% to 7.4-16.5% between the 5-6 year follow-up and a later assessment. When comparing traditional responders to non-traditional responders (volunteers), the probable PTSD prevalence 2.5 years after the initial visit was greater in volunteers with estimates of 11.7% and 17.2% respectively. Volunteer participation in tasks atypical to the defined occupational role was a significant risk factor for PTSD. Other risk factors included exposure intensity, earlier start date, duration of time spent on site, and constant, negative reminders of the trauma. Additional research has been performed to understand the social consequences of the September 11 attacks. Alcohol consumption was assessed in a cohort of World Trade Center workers using the cut-annoyed-guilty-eye (CAGE) questionnaire for alcohol use disorder. Almost 50% of World Trade Center workers who self-identified as alcohol users reported drinking more during the rescue efforts. Nearly a quarter of these individuals reported drinking more following the recovery. If determined to have probable PTSD status, the risk of developing an alcohol problem was double compared to those without psychological morbidity. Social disability was also studied in this cohort as a social consequence of the September 11 attacks. Defined by the disruption of family, work, and social life, the risk of developing social disability increased 17-fold when categorized as having probable PTSD.
The United States provides a range of benefits for veterans that the VA has determined have PTSD, which developed during, or as a result of, their military service. These benefits may include tax-free cash payments, free or low-cost mental health treatment and other healthcare, vocational rehabilitation services, employment assistance, and independent living support.
In the UK, there are various charities and service organisations dedicated to aiding veterans in readjusting to civilian life. The Royal British Legion and the more recently established Help for Heroes are two of Britain's more high-profile veterans' organisations which have actively advocated for veterans over the years. There has been some controversy that the NHS has not done enough in tackling mental health issues and is instead "dumping" veterans on charities such as Combat Stress.
The 1952 edition of the DSM-I includes a diagnosis of "gross stress reaction", which has similarities to the modern definition and understanding of PTSD. Gross stress reaction is defined as a normal personality using established patterns of reaction to deal with overwhelming fear as a response to conditions of great stress. The diagnosis includes language which relates the condition to combat as well as to "civilian catastrophe".
A USAF study carried out in 1979 focused on individuals (civilian and military) who had worked to recover or identify the remains of those who died in Jonestown. The bodies had been dead for several days, and a third of them had been children. The study used the term "dysphoria" to describe PTSD-like symptoms.
Early in 1978, the diagnosis term "post-traumatic stress disorder" was first recommended in a working group finding presented to the Committee of Reactive Disorders. The condition was described in the DSM-III (1980) as posttraumatic stress disorder. In the DSM-IV, the spelling "posttraumatic stress disorder" is used, while in the ICD-10, the spelling is "post-traumatic stress disorder".
Statue, Three Servicemen, Vietnam Veterans Memorial
The correlations between combat and PTSD are undeniable; according to Stéphane Audoin-Rouzeau and Annette Becker, "One-tenth of mobilized American men were hospitalized for mental disturbances between 1942 and 1945, and, after thirty-five days of uninterrupted combat, 98% of them manifested psychiatric disturbances in varying degrees." In fact, much of the available published research regarding PTSD is based on studies done on veterans of the war in Vietnam. A study based on personal letters from soldiers of the 18th-century Prussian Army concludes that combatants may have had PTSD. Aspects of PTSD in soldiers of ancient Assyria have been identified using written sources from 1300–600 BCE. These Assyrian soldiers would undergo a three-year rotation of combat before being allowed to return home, and were reported to have faced immense challenges in reconciling their past actions in war with their civilian lives. Connections between the actions of Viking berserkers and the hyperarousal of post-traumatic stress disorder have also been drawn.
The researchers from the Grady Trauma Project highlight the tendency people have to focus on the combat side of PTSD: "less public awareness has focused on civilian PTSD, which results from trauma exposure that is not combat related... " and "much of the research on civilian PTSD has focused on the sequelae of a single, disastrous event, such as the Oklahoma City bombing, September 11th attacks, and Hurricane Katrina". Disparity in the focus of PTSD research affects the already popular perception of the exclusive interconnectedness of combat and PTSD. This is misleading when it comes to understanding the implications and extent of PTSD as a neurological disorder. Dating back to the definition of Gross stress reaction in the DSM-I, civilian experience of catastrophic or high stress events is included as a cause of PTSD in medical literature. The 2014 National Comorbidity Survey reports that "the traumas most commonly associated with PTSD are combat exposure and witnessing among men and rape and sexual molestation among women."
Because of the initial overt focus on PTSD as a combat related disorder when it was first fleshed out in the years following the war in Vietnam, in 1975 Ann Wolbert Burgess and Lynda Lytle Holmstrom defined rape trauma syndrome (RTS) in order to draw attention to the striking similarities between the experiences of soldiers returning from war and of rape victims. This paved the way for a more comprehensive understanding of causes of PTSD.
After PTSD became an official psychiatric diagnosis with the publication of DSM-III (1980), the number of personal injury lawsuits (tort claims) asserting the plaintiff suffered from PTSD increased rapidly. However, triers of fact (judges and juries) often regarded the PTSD diagnostic criteria as imprecise, a view shared by legal scholars, trauma specialists, forensic psychologists, and forensic psychiatrists. Professional discussions and debates in academic journals, at conferences, and between thought leaders, led to a more clearly-defined set of diagnostic criteria in DSM-IV, particularly the definition of a "traumatic event".
The DSM-IV classified PTSD under anxiety disorders, but the DSM-5 created a new category called "trauma and stressor-related disorders", in which PTSD is now classified.
The Diagnostic and Statistical Manual of Mental Disorders does not hyphenate "post" and "traumatic", thus, the DSM-5 lists the disorder as posttraumatic stress disorder. However, many scientific journal articles and other scholarly publications do hyphenate the name of the disorder, viz., "post-traumatic stress disorder". Dictionaries also differ with regard to the preferred spelling of the disorder with the Collins English Dictionary – Complete and Unabridged using the hyphenated spelling, and the American Heritage Dictionary of the English Language, Fifth Edition and the Random House Kernerman Webster's College Dictionary giving the non-hyphenated spelling.
Some authors have used the terms "post-traumatic stress syndrome" or "post-traumatic stress symptoms" ("PTSS"), or simply "post-traumatic stress" ("PTS") in the case of the U.S. Department of Defense, to avoid stigma associated with the word "disorder".
The comedian George Carlin criticized the euphemism treadmill which led to progressive change of the way PTSD was referred to over the course of the 20th century, from "shell shock" in the First World War to the "battle fatigue" in the Second World War, to "operational exhaustion" in the Korean War, to the current "post-traumatic stress disorder", coined during the Vietnam War, which "added a hyphen" and which, he commented, "completely burie[s] [the pain] under jargon". He also stated that the name given to the condition has had a direct effect on the way veteran soldiers with PTSD were treated and perceived by civilian populations over time.
Most knowledge regarding PTSD comes from studies in high-income countries.
To recapitulate some of the neurological and neurobehavioral symptoms experienced by the veteran population of recent conflicts in Iraq and Afghanistan, researchers at the Roskamp Institute and the James A Haley Veteran's Hospital (Tampa) have developed an animal model to study the consequences of mild traumatic brain injury (mTBI) and PTSD. In the laboratory, the researchers exposed mice to a repeated session of unpredictable stressor (i.e. predator odor while restrained), and physical trauma in the form of inescapable foot-shock, and this was also combined with a mTBI. In this study, PTSD animals demonstrated recall of traumatic memories, anxiety, and an impaired social behavior, while animals subject to both mTBI and PTSD had a pattern of disinhibitory-like behavior. mTBI abrogated both contextual fear and impairments in social behavior seen in PTSD animals. In comparison with other animal studies, examination of neuroendocrine and neuroimmune responses in plasma revealed a trend toward increase in corticosterone in PTSD and combination groups.
Researchers are investigating a number of experimental FAAH and MAGL-inhibiting drugs of hopes of finding a better treatment for anxiety and stress-related illnesses. In 2016, the FAAH-inhibitor drug BIA 10-2474 was withdrawn from human trials in France due to adverse effects.
Preliminary evidence suggests that MDMA-assisted psychotherapy might be an effective treatment for PTSD. However, it is important to note that the results in clinical trials of MDMA-assisted psychotherapy might be substantially influenced by expectancy effects given the unblinding of participants. Furthermore, there is a conspicuous lack of trials comparing MDMA-assisted psychotherapy to existent first-line treatments for PTSD, such as trauma-focused psychological treatments, which seems to achieve similar or even better outcomes than MDMA-assisted psychotherapy.
Trauma-focused psychotherapies for PTSD (also known as "exposure-based" or "exposure" psychotherapies), such as prolonged exposure therapy (PE), eye movement desensitization and reprocessing (EMDR), and cognitive-reprocessing therapy (CPT) have the most evidence for efficacy and are recommended as first-line treatment for PTSD by almost all clinical practice guidelines. Exposure-based psychotherapies demonstrate efficacy for PTSD caused by different trauma "types", such as combat, sexual-assault, or natural disasters. At the same time, many trauma-focused psychotherapies evince high drop-out rates.
Most systematic reviews and clinical guidelines indicate that psychotherapies for PTSD, most of which are trauma-focused therapies, are more effective than pharmacotherapy (medication), although there are reviews that suggest exposure-based psychotherapies for PTSD and pharmacotherapy are equally effective. Interpersonal psychotherapy shows preliminary evidence of probable efficacy, but more research is needed to reach definitive conclusions.
^Acceptable variants of this term exist; see the Terminology section in this article.
^As an example of such research, see: Bonn-Miller MO, Sisley S, Riggs P, Yazar-Klosinski B, Wang JB, Loflin MJE, et al. (2021) The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial. PLoS ONE 16(3): e0246990.
^ abcdefghijklmnoAmerican Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing. pp. 271–80. ISBN 978-0-89042-555-8.
^ abcdefghBisson JI, Cosgrove S, Lewis C, Robert NP (November 2015). "Post-traumatic stress disorder". BMJ. 351: h6161. doi:10.1136/bmj.h6161. PMC4663500. PMID26611143.
^ abcdef"Post-Traumatic Stress Disorder". National Institute of Mental Health. February 2016. Archived from the original on 9 March 2016. Retrieved 10 March 2016.
^ abcdeBerger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, Figueira I (March 2009). "Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33 (2): 169–80. doi:10.1016/j.pnpbp.2008.12.004. PMC2720612. PMID19141307.
^Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association. 2013. p. 276. ISBN 9780890425558. OCLC 830807378.
^Drs; Sartorius, Norman; Henderson, A.S.; Strotzka, H.; Lipowski, Z.; Yu-cun, Shen; You-xin, Xu; Strömgren, E.; Glatzel, J.; Kühne, G.-E.; Misès, R.; Soldatos, C.R.; Pull, C.B.; Giel, R.; Jegede, R.; Malt, U.; Nadzharov, R.A.; Smulevitch, A.B.; Hagberg, B.; Perris, C.; Scharfetter, C.; Clare, A.; Cooper, J.E.; Corbett, J.A.; Griffith Edwards, J.; Gelder, M.; Goldberg, D.; Gossop, M.; Graham, P.; Kendell, R.E.; Marks, I.; Russell, G.; Rutter, M.; Shepherd, M.; West, D.J.; Wing, J.; Wing, L.; Neki, J.S.; Benson, F.; Cantwell, D.; Guze, S.; Helzer, J.; Holzman, P.; Kleinman, A.; Kupfer, D.J.; Mezzich, J.; Spitzer, R.; Lokar, J. "The ICD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines" (PDF). www.who.int World Health Organization. Microsoft Word. bluebook.doc. p. 110. Retrieved 3 July 2021 – via Microsoft Bing.
^"Post-traumatic stress disorder (PTSD) - Symptoms and causes". Mayo Clinic. Retrieved 8 October 2019.
^Panagioti M, Gooding PA, Triantafyllou K, Tarrier N (April 2015). "Suicidality and posttraumatic stress disorder (PTSD) in adolescents: a systematic review and meta-analysis". Social Psychiatry and Psychiatric Epidemiology. 50 (4): 525–37. doi:10.1007/s00127-014-0978-x. PMID25398198. S2CID 23314414.
^Zoladz PR, Diamond DM (June 2013). "Current status on behavioral and biological markers of PTSD: a search for clarity in a conflicting literature". Neuroscience and Biobehavioral Reviews. 37 (5): 860–95. doi:10.1016/j.neubiorev.2013.03.024. PMID23567521. S2CID 14440116.
^Kessler, Ronald C.; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Benjet, Corina; Bromet, Evelyn J.; Cardoso, Graça; Degenhardt, Louisa; Girolamo, Giovanni de; Dinolova, Rumyana V.; Ferry, Finola; Florescu, Silvia (27 October 2017). "Trauma and PTSD in the WHO World Mental Health Surveys". European Journal of Psychotraumatology. 8 (sup5): 1353383. doi:10.1080/20008198.2017.1353383. ISSN 2000-8198. PMC5632781. PMID29075426. As detailed in another recent WMH report, conditional risk of PTSD after trauma exposure is 4.0%, but varies significantly by trauma type. The highest conditional risk is associated with being raped (19.0%), physical abuse by a romantic partner (11.7%), being kidnapped (11.0%), and being sexually assaulted other than rape (10.5%). In terms of broader categories, the traumas associated with the highest PTSD risk are those involving intimate partner or sexual violence (11.4%), and other traumas (9.2%), with aggregate conditional risk much lower in the other broad trauma categories (2.0–5.4%) [citations omitted; emphasis added].
^Darves-Bornoz, Jean-Michel; Alonso, Jordi; Girolamo, Giovanni de; Graaf, Ron de; Haro, Josep-Maria; Kovess-Masfety, Viviane; Lepine, Jean-Pierre; Nachbaur, Gaëlle; Negre-Pages, Laurence; Vilagut, Gemma; Gasquet, Isabelle (2008). "Main traumatic events in Europe: PTSD in the European study of the epidemiology of mental disorders survey". Journal of Traumatic Stress. 21 (5): 455–462. doi:10.1002/jts.20357. ISSN 1573-6598. PMID18956444. In univariate analyses adjusted on gender, six events were found to be the most significantly associated with PTSD ( p < .001) among individuals exposed to at least one event. They were being raped (OR = 8.9), being beaten up by spouse or romantic partner (OR = 7.3), experiencing an undisclosed private event (OR = 5.5), having a child with serious illness (OR = 5.1), being beaten up by a caregiver (OR = 4.5), or being stalked (OR = 4.2)" [OR = odds ratio].
^Brewin CR, Cloitre M, Hyland P, Shevlin M, Maercker A, Bryant RA, et al. (December 2017). "A review of current evidence regarding the ICD-11 proposals for diagnosing PTSD and complex PTSD" (PDF). Clinical Psychology Review. 58: 1–15. doi:10.1016/j.cpr.2017.09.001. PMID 29029837.
^ abHaagen JF, Smid GE, Knipscheer JW, Kleber RJ (August 2015). "The efficacy of recommended treatments for veterans with PTSD: A metaregression analysis". Clinical Psychology Review. 40: 184–94. doi:10.1016/j.cpr.2015.06.008. PMID26164548.
^ abHetrick SE, Purcell R, Garner B, Parslow R (July 2010). "Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews (7): CD007316. doi:10.1002/14651858.CD007316.pub2. PMID20614457.
^ abcGuina J, Rossetter SR, DeRHODES BJ, Nahhas RW, Welton RS (July 2015). "Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis". Journal of Psychiatric Practice. 21 (4): 281–303. doi:10.1097/pra.0000000000000091. PMID26164054. S2CID 24968844.
^ abcdHoskins M, Pearce J, Bethell A, Dankova L, Barbui C, Tol WA, van Ommeren M, de Jong J, Seedat S, Chen H, Bisson JI (February 2015). "Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis". The British Journal of Psychiatry. 206 (2): 93–100. doi:10.1192/bjp.bp.114.148551. PMID25644881. Some drugs have a small positive impact on PTSD symptoms
^Carlstedt R (2009). Handbook of Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine Perspectives, Practices, and Research. New York: Springer Pub. Co. p. 353. ISBN 9780826110954.
^O'Brien, Samuel (1998). Traumatic Events and Mental Health. Cambridge University Press. p. 7.
^Herman J (2015). Trauma and Recovery: The Aftermath of Violence – From Domestic Abuse to Political Terror. Basic Books. p. 9. ISBN 9780465098736.
^Klykylo WM (2012). Clinical child psychiatry (3 ed.). Chichester, West Sussex, UK: John Wiley & Sons. p. Chapter 15. ISBN 9781119967705.
^Friedman MJ (October 2013). "Finalizing PTSD in DSM-5: getting here from there and where to go next". Journal of Traumatic Stress. 26 (5): 548–56. doi:10.1002/jts.21840. PMID24151001.
^ abWaltman, Scott H.; Shearer, David; Moore, Bret A. (11 October 2018). "Management of Post-Traumatic Nightmares: a Review of Pharmacologic and Nonpharmacologic Treatments Since 2013". Current Psychiatry Reports. Springer Science and Business Media LLC. 20 (12): 108. doi:10.1007/s11920-018-0971-2. ISSN 1523-3812. PMID30306339. S2CID 52958432.
^ abcAmerican Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders: DSM-IV. Washington, DC: American Psychiatric Association. ISBN 978-0-89042-061-4.[page needed]; on-line.
^ abRothschild B (2000). The Body Remembers: The Psychophysiology of Trauma and Trauma Treatment. New York: W.W. Norton & Company. ISBN 978-0-393-70327-6.[page needed]
^Kaplan HI, Sadock BJ (1994). Grebb JA (ed.). Kaplan and Sadock's synopsis of psychiatry: Behavioral sciences, clinical psychiatry (7th ed.). Baltimore: Williams & Williams. pp. 606–609.[page needed]
^Bernstein M, Pfefferbaum B (May 2018). "Posttraumatic Growth as a Response to Natural Disasters in Children and Adolescents". Current Psychiatry Reports. 20 (5): 37. doi:10.1007/s11920-018-0900-4. PMID29766312. S2CID 21721645.
^O'Donnell ML, Creamer M, Bryant RA, Schnyder U, Shalev A (July 2003). "Posttraumatic disorders following injury: an empirical and methodological review". Clinical Psychology Review. 23 (4): 587–603. doi:10.1016/S0272-7358(03)00036-9. PMID12788111.
^Maxmen JS, Ward NG (2002). Psychotropic drugs: fast facts (3rd ed.). New York: W. W. Norton. p. 348. ISBN 978-0-393-70301-6.
^Cohen SI (February 1995). "Alcohol and benzodiazepines generate anxiety, panic and phobias". Journal of the Royal Society of Medicine. 88 (2): 73–7. PMC1295099. PMID7769598.
^Spates R, Souza T (2007). "Treatment of PTSD and Substance Abuse Comorbidity" (PDF). The Behavior Analyst Today. 9 (1): 11–26. doi:10.1037/h0100643. Archived from the original (PDF) on 6 November 2014.
^Villalta L, Smith P, Hickin N, Stringaris A (April 2018). "Emotion regulation difficulties in traumatized youth: a meta-analysis and conceptual review" (PDF). European Child & Adolescent Psychiatry. 27 (4): 527–544. doi:10.1007/s00787-018-1105-4. PMID29380069. S2CID 4731753.
^Robinson M (27 May 2006). "Review of Francisco Goya's Disasters of War". Associated Press. Archived from the original on 28 July 2014.
^Fullerton CS, Ursano RJ, Wang L (August 2004). "Acute stress disorder, posttraumatic stress disorder, and depression in disaster or rescue workers". The American Journal of Psychiatry. 161 (8): 1370–6. CiteSeerX10.1.1.600.4486. doi:10.1176/appi.ajp.161.8.1370. PMID15285961.
^Skogstad M, Skorstad M, Lie A, Conradi HS, Heir T, Weisæth L (April 2013). "Work-related post-traumatic stress disorder". Occupational Medicine. 63 (3): 175–82. doi:10.1093/occmed/kqt003. PMID23564090.
^Vieweg WV, Julius DA, Fernandez A, Beatty-Brooks M, Hettema JM, Pandurangi AK (May 2006). "Posttraumatic stress disorder: clinical features, pathophysiology, and treatment". The American Journal of Medicine. 119 (5): 383–90. doi:10.1016/j.amjmed.2005.09.027. PMID16651048.
^Dekel S, Gilbertson MW, Orr SP, Rauch SL, Wood NE, Pitman RK (2016). "Trauma and Posttraumatic Stress Disorder". In Stern TA, Fava M, Wilens TE, Rosenbaum JF (eds.). Massachusetts General Hospital comprehensive clinical psychiatry (Second ed.). London: Elsevier. pp. 380–392. ISBN 9780323295079. OCLC 905232521.
^ abcdeKessler RC, Aguilar-Gaxiola S, Alonso J, Benjet C, Bromet EJ, Cardoso G, Degenhardt L, de Girolamo G, Dinolova RV, Ferry F, Florescu S, Gureje O, Haro JM, Huang Y, Karam EG, Kawakami N, Lee S, Lepine JP, Levinson D, Navarro-Mateu F, Pennell BE, Piazza M, Posada-Villa J, Scott KM, Stein DJ, Ten Have M, Torres Y, Viana MC, Petukhova MV, Sampson NA, Zaslavsky AM, Koenen KC (27 October 2017). "Trauma and PTSD in the WHO World Mental Health Surveys". European Journal of Psychotraumatology. 8 (sup5): 1353383. doi:10.1080/20008198.2017.1353383. PMC5632781. PMID29075426.
^National Collaborating Centre for Mental Health (UK) (2005). Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care. NICE Clinical Guidelines, No. 26. National Institute for Health and Clinical Excellence: Guidance. Gaskell (Royal College of Psychiatrists). ISBN 9781904671251.
^ abLin W, Gong L, Xia M, Dai W (January 2018). "Prevalence of posttraumatic stress disorder among road traffic accident survivors: A PRISMA-compliant meta-analysis". Medicine. 97 (3): e9693. doi:10.1097/md.0000000000009693. PMC5779792. PMID29505023.
^ abDai W, Liu A, Kaminga AC, Deng J, Lai Z, Wen SW (August 2018). "Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis". Canadian Journal of Psychiatry. 63 (12): 798–808. doi:10.1177/0706743718792194. PMC6309043. PMID30081648.
^Bisson JI, Berliner L, Cloitre M, Forbes D, Jensen TK, Lewis C, Monson CM, Olff M, Pilling S, Riggs DS, Roberts NP, Shapiro F (August 2019). "The International Society for Traumatic Stress Studies New Guidelines for the Prevention and Treatment of Posttraumatic Stress Disorder: Methodology and Development Process" (PDF). Journal of Traumatic Stress. 32 (4): 475–483. doi:10.1002/jts.22421. hdl:10852/77258. PMID31283056. S2CID 195830995.
^ abcdefgNational Collaborating Centre for Mental Health (UK) (2005). Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care. National Institute for Health and Clinical Excellence: Guidance No. 26. Gaskell (Royal College of Psychiatrists). ISBN 9781904671251. Archived from the original on 8 September 2017.
^Alisic E, Zalta AK, van Wesel F, Larsen SE, Hafstad GS, Hassanpour K, Smid GE (2014). "Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: meta-analysis" (PDF). The British Journal of Psychiatry. 204 (5): 335–40. doi:10.1192/bjp.bp.113.131227. PMID24785767.
^Lai BS, Lewis R, Livings MS, La Greca AM, Esnard AM (December 2017). "Posttraumatic Stress Symptom Trajectories Among Children After Disaster Exposure: A Review". Journal of Traumatic Stress. 30 (6): 571–582. doi:10.1002/jts.22242. PMC5953201. PMID29193316.
^Koenen KC, Moffitt TE, Poulton R, Martin J, Caspi A (February 2007). "Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort". Psychological Medicine. 37 (2): 181–92. doi:10.1017/S0033291706009019. PMC2254221. PMID17052377.
^Lapp KG, Bosworth HB, Strauss JL, Stechuchak KM, Horner RD, Calhoun PS, Meador KG, Lipper S, Butterfield MI (September 2005). "Lifetime sexual and physical victimization among male veterans with combat-related post-traumatic stress disorder". Military Medicine. 170 (9): 787–90. doi:10.7205/MILMED.170.9.787. PMID16261985.
^Otte C, Neylan TC, Pole N, Metzler T, Best S, Henn-Haase C, Yehuda R, Marmar CR (January 2005). "Association between childhood trauma and catecholamine response to psychological stress in police academy recruits". Biological Psychiatry. 57 (1): 27–32. doi:10.1016/j.biopsych.2004.10.009. PMID15607297. S2CID 35801179.
^ abcdefghiSkelton K, Ressler KJ, Norrholm SD, Jovanovic T, Bradley-Davino B (February 2012). "PTSD and gene variants: new pathways and new thinking". Neuropharmacology. 62 (2): 628–37. doi:10.1016/j.neuropharm.2011.02.013. PMC3136568. PMID21356219.
^Janoff-Bulman R (1992). Shattered Assumptions: Toward a New Psychology of Trauma. New York: Free Press.[page needed]
^Scheeringa MS (2015). "Untangling Psychiatric Comorbidity in Young Children Who Experienced Single, Repeated, or Hurricane Katrina Traumatic Events". Child and Youth Care Forum. 44 (4): 475–492. doi:10.1007/s10566-014-9293-7. PMC4511493. PMID26213455.
^ abcdKessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (December 1995). "Posttraumatic stress disorder in the National Comorbidity Survey". Archives of General Psychiatry. 52 (12): 1048–60. doi:10.1001/archpsyc.1995.03950240066012. PMID7492257.
^Liu H, Petukhova MV, Sampson NA, Aguilar-Gaxiola S, Alonso J, Andrade LH, Bromet EJ, de Girolamo G, Haro JM, Hinkov H, Kawakami N, Koenen KC, Kovess-Masfety V, Lee S, Medina-Mora ME, Navarro-Mateu F, O'Neill S, Piazza M, Posada-Villa J, Scott KM, Shahly V, Stein DJ, Ten Have M, Torres Y, Gureje O, Zaslavsky AM, Kessler RC (March 2017). "Association of DSM-IV Posttraumatic Stress Disorder With Traumatic Experience Type and History in the World Health Organization World Mental Health Surveys". JAMA Psychiatry. 74 (3): 270–281. doi:10.1001/jamapsychiatry.2016.3783. PMC5441566. PMID28055082.
^Rothschild B (2000). The Body Remembers: The Psychophysiology of Trauma and Trauma Treatment. New York: W.W. Norton & Company. ISBN 978-0-393-70327-6.[page needed]
^Howard LM, Oram S, Galley H, Trevillion K, Feder G (2013). "Domestic violence and perinatal mental disorders: a systematic review and meta-analysis". PLOS Medicine. 10 (5): e1001452. doi:10.1371/journal.pmed.1001452. PMC3665851. PMID23723741.
^Hoffman BL, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM, eds. (2016). Williams Gynecology (3rd ed.). McGraw Hill Professional. ISBN 9780071849098.
^Surís A, Lind L, Kashner TM, Borman PD, Petty F (2004). "Sexual assault in women veterans: an examination of PTSD risk, health care utilization, and cost of care". Psychosomatic Medicine. 66 (5): 749–56. CiteSeerX10.1.1.508.9827. doi:10.1097/01.psy.0000138117.58559.7b. PMID15385701. S2CID 14118203.
^Mason F, Lodrick Z (February 2013). "Psychological consequences of sexual assault". Best Practice & Research. Clinical Obstetrics & Gynaecology. 27 (1): 27–37. doi:10.1016/j.bpobgyn.2012.08.015. PMID23182852.
^ abShalev A, Liberzon I, Marmar C (June 2017). "Post-Traumatic Stress Disorder". The New England Journal of Medicine. 376 (25): 2459–2469. doi:10.1056/NEJMra1612499. PMID28636846.
^Hollifield M, Warner TD, Lian N, Krakow B, Jenkins JH, Kesler J, Stevenson J, Westermeyer J (August 2002). "Measuring trauma and health status in refugees: a critical review". JAMA. 288 (5): 611–21. doi:10.1001/jama.288.5.611. PMID12150673.
^Porter M, Haslam N (October 2001). "Forced displacement in Yugoslavia: a meta-analysis of psychological consequences and their moderators". Journal of Traumatic Stress. 14 (4): 817–34. doi:10.1023/A:1013054524810. PMID11776427. S2CID 41804120.
^ abUNESCO (2018). A Lifeline to learning: leveraging mobile technology to support education for refugees. UNESCO. ISBN 978-92-3-100262-5.
^ abAtwoli L, Stein DJ, King A, Petukhova M, Aguilar-Gaxiola S, Alonso J, Bromet EJ, de Girolamo G, Demyttenaere K, Florescu S, Maria Haro J, Karam EG, Kawakami N, Lee S, Lepine JP, Navarro-Mateu F, O'Neill S, Pennell BE, Piazza M, Posada-Villa J, Sampson NA, Ten Have M, Zaslavsky AM, Kessler RC (April 2017). "Posttraumatic stress disorder associated with unexpected death of a loved one: Cross-national findings from the world mental health surveys". Depression and Anxiety. 34 (4): 315–326. doi:10.1002/da.22579. PMC5661943. PMID27921352.
^ ab"Cancer-Related Post-traumatic Stress". National Cancer Institute. January 1980. Retrieved 16 September 2017.
^Swartzman S, Booth JN, Munro A, Sani F (April 2017). "Posttraumatic stress disorder after cancer diagnosis in adults: A meta-analysis". Depression and Anxiety (Submitted manuscript). 34 (4): 327–339. doi:10.1002/da.22542. PMID27466972. S2CID 1828418.
^Cordova MJ, Riba MB, Spiegel D (April 2017). "Post-traumatic stress disorder and cancer". The Lancet. Psychiatry. 4 (4): 330–338. doi:10.1016/S2215-0366(17)30014-7. PMC5676567. PMID28109647.
^Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y (2012). "Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review". PLOS ONE. 7 (6): e38915. Bibcode:2012PLoSO...738915E. doi:10.1371/journal.pone.0038915. PMC3380054. PMID22745687.
^Edmondson D, Richardson S, Fausett JK, Falzon L, Howard VJ, Kronish IM (19 June 2013). "Prevalence of PTSD in Survivors of Stroke and Transient Ischemic Attack: A Meta-Analytic Review". PLOS ONE. 8 (6): e66435. Bibcode:2013PLoSO...866435E. doi:10.1371/journal.pone.0066435. PMC3686746. PMID23840467.
^Abbey G, Thompson SB, Hickish T, Heathcote D (April 2015). "A meta-analysis of prevalence rates and moderating factors for cancer-related post-traumatic stress disorder". Psycho-Oncology. 24 (4): 371–81. doi:10.1002/pon.3654. PMC4409098. PMID25146298.
^Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ (September 2008). "Posttraumatic stress disorder in general intensive care unit survivors: a systematic review". General Hospital Psychiatry. 30 (5): 421–34. doi:10.1016/j.genhosppsych.2008.05.006. PMC2572638. PMID18774425.
^Arnaboldi P, Riva S, Crico C, Pravettoni G (2017). "A systematic literature review exploring the prevalence of post-traumatic stress disorder and the role played by stress and traumatic stress in breast cancer diagnosis and trajectory". Breast Cancer: Targets and Therapy. 9: 473–485. doi:10.2147/BCTT.S111101. PMC5505536. PMID28740430.
^Liu C, Zhang Y, Jiang H, Wu H (5 May 2017). "Association between social support and post-traumatic stress disorder symptoms among Chinese patients with ovarian cancer: A multiple mediation model". PLOS ONE. 12 (5): e0177055. Bibcode:2017PLoSO..1277055L. doi:10.1371/journal.pone.0177055. PMC5419605. PMID28475593.
^"PsycNET". psycnet.apa.org. Retrieved 30 September 2018.
^ abChristiansen DM (February 2017). "Posttraumatic stress disorder in parents following infant death: A systematic review". Clinical Psychology Review. 51: 60–74. doi:10.1016/j.cpr.2016.10.007. PMID27838460.
^Kersting A, Wagner B (June 2012). "Complicated grief after perinatal loss". Dialogues in Clinical Neuroscience. 14 (2): 187–94. doi:10.31887/DCNS.2012.14.2/akersting. PMC3384447. PMID22754291.
^Daugirdaitė V, van den Akker O, Purewal S (2015). "Posttraumatic stress and posttraumatic stress disorder after termination of pregnancy and reproductive loss: a systematic review". Journal of Pregnancy. 2015: 646345. doi:10.1155/2015/646345. PMC4334933. PMID25734016.
^Ayers S, Bond R, Bertullies S, Wijma K (April 2016). "The aetiology of post-traumatic stress following childbirth: a meta-analysis and theoretical framework". Psychological Medicine. 46 (6): 1121–34. doi:10.1017/s0033291715002706. PMID26878223.
^James S (December 2015). "Women's experiences of symptoms of posttraumatic stress disorder (PTSD) after traumatic childbirth: a review and critical appraisal". Archives of Women's Mental Health. 18 (6): 761–71. doi:10.1007/s00737-015-0560-x. PMC4624822. PMID26264506.
^ abcOlde E, van der Hart O, Kleber R, van Son M (January 2006). "Posttraumatic stress following childbirth: a review". Clinical Psychology Review. 26 (1): 1–16. doi:10.1016/j.cpr.2005.07.002. hdl:1874/16760. PMID16176853.
^Alder J, Stadlmayr W, Tschudin S, Bitzer J (June 2006). "Post-traumatic symptoms after childbirth: what should we offer?". Journal of Psychosomatic Obstetrics and Gynaecology. 27 (2): 107–12. doi:10.1080/01674820600714632. PMID16808085. S2CID 21859634.
^Montmasson H, Bertrand P, Perrotin F, El-Hage W (October 2012). "[Predictors of postpartum post-traumatic stress disorder in primiparous mothers]". Journal de Gynécologie, Obstétrique et Biologie de la Reproduction. 41 (6): 553–60. doi:10.1016/j.jgyn.2012.04.010. PMID22622194.
^Martin C (2012). Perinatal Mental Health : a Clinical Guide. Cumbria England: M & K Pub. p. 26. ISBN 9781907830495.
^True WR, Rice J, Eisen SA, Heath AC, Goldberg J, Lyons MJ, Nowak J (April 1993). "A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms". Archives of General Psychiatry. 50 (4): 257–64. doi:10.1001/archpsyc.1993.01820160019002. PMID8466386.
^Quidé, Y.; Andersson, F.; Dufour-Rainfray, D.; Descriaud, C.; Brizard, B.; Gissot, V.; Cléry, H.; Carrey Le Bas, M-P.; Osterreicher, S.; Ogielska, M.; Saint-Martin, P. (October 2018). "Smaller hippocampal volume following sexual assault in women is associated with post-traumatic stress disorder". Acta Psychiatrica Scandinavica. 138 (4): 312–324. doi:10.1111/acps.12920. PMID29952088. S2CID 49484570.
^Yamasue H, Kasai K, Iwanami A, Ohtani T, Yamada H, Abe O, Kuroki N, Fukuda R, Tochigi M, Furukawa S, Sadamatsu M, Sasaki T, Aoki S, Ohtomo K, Asukai N, Kato N (July 2003). "Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 9039–43. Bibcode:2003PNAS..100.9039Y. doi:10.1073/pnas.1530467100. PMC166434. PMID12853571.
^Delahanty DL (January 2011). "Toward the predeployment detection of risk for PTSD". The American Journal of Psychiatry. 168 (1): 9–11. doi:10.1176/appi.ajp.2010.10101519. PMID21205813.
^The Secret Life of the Brain (Series), episode 4. PBS. 2001. Archived from the original on 2 February 2014. Retrieved 29 January 2014.
^ abZohar J, Juven-Wetzler A, Myers V, Fostick L (January 2008). "Post-traumatic stress disorder: facts and fiction". Current Opinion in Psychiatry. 21 (1): 74–7. doi:10.1097/YCO.0b013e3282f269ee. PMID18281844. S2CID 206142172.
^Yehuda R, Halligan SL, Golier JA, Grossman R, Bierer LM (April 2004). "Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder". Psychoneuroendocrinology. 29 (3): 389–404. doi:10.1016/S0306-4530(03)00052-0. PMID14644068. S2CID 21615196.
^Yehuda R, Halligan SL, Grossman R, Golier JA, Wong C (September 2002). "The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder". Biological Psychiatry. 52 (5): 393–403. doi:10.1016/S0006-3223(02)01357-4. PMID12242055. S2CID 21403230.
^Heim C, Ehlert U, Hellhammer DH (January 2000). "The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders". Psychoneuroendocrinology. 25 (1): 1–35. doi:10.1016/S0306-4530(99)00035-9. PMID10633533. S2CID 25151441.
^Mason JW, Giller EL, Kosten TR, Harkness L (August 1988). "Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder". The Journal of Nervous and Mental Disease. 176 (8): 498–502. doi:10.1097/00005053-198808000-00008. PMID3404142. S2CID 24585702.
^Bohnen N, Nicolson N, Sulon J, Jolles J (1991). "Coping style, trait anxiety and cortisol reactivity during mental stress". Journal of Psychosomatic Research. 35 (2–3): 141–7. CiteSeerX10.1.1.467.4323. doi:10.1016/0022-3999(91)90068-Y. PMID2046048.
^Geracioti TD, Baker DG, Ekhator NN, West SA, Hill KK, Bruce AB, Schmidt D, Rounds-Kugler B, Yehuda R, Keck PE, Kasckow JW (August 2001). "CSF norepinephrine concentrations in posttraumatic stress disorder". The American Journal of Psychiatry. 158 (8): 1227–30. doi:10.1176/appi.ajp.158.8.1227. PMID11481155.
^Sautter FJ, Bissette G, Wiley J, Manguno-Mire G, Schoenbachler B, Myers L, Johnson JE, Cerbone A, Malaspina D (December 2003). "Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects". Biological Psychiatry. 54 (12): 1382–8. doi:10.1016/S0006-3223(03)00571-7. PMID14675802. S2CID 35766262.
^de Kloet CS, Vermetten E, Geuze E, Lentjes EG, Heijnen CJ, Stalla GK, Westenberg HG (2008). "Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder". Stress Hormones and Post Traumatic Stress Disorder Basic Studies and Clinical Perspectives. Progress in Brain Research. Vol. 167. pp. 287–91. doi:10.1016/S0079-6123(07)67025-3. ISBN 978-0-444-53140-7. PMID18037027.
^Radley JJ, Kabbaj M, Jacobson L, Heydendael W, Yehuda R, Herman JP (September 2011). "Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes". Stress. 14 (5): 481–97. doi:10.3109/10253890.2011.604751. PMC3641164. PMID21848436.
^Yehuda R (2001). "Biology of posttraumatic stress disorder". The Journal of Clinical Psychiatry. 62. 62 Suppl 17: 41–6. PMID11495096.
^Yehuda R (2002). "Clinical relevance of biologic findings in PTSD". The Psychiatric Quarterly. 73 (2): 123–33. doi:10.1023/A:1015055711424. PMID12025720. S2CID 19767960.
^Aardal-Eriksson E, Eriksson TE, Thorell LH (December 2001). "Salivary cortisol, posttraumatic stress symptoms, and general health in the acute phase and during 9-month follow-up". Biological Psychiatry. 50 (12): 986–93. doi:10.1016/S0006-3223(01)01253-7. PMID11750895. S2CID 9149956.
^ abcdeOlszewski TM, Varrasse JF (June 2005). "The neurobiology of PTSD: implications for nurses". Journal of Psychosocial Nursing and Mental Health Services. 43 (6): 40–7. doi:10.3928/02793695-20050601-09. PMID16018133.
^Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW (20 July 2017). "Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming". Frontiers in Endocrinology. 8: 163. doi:10.3389/fendo.2017.00163. PMC5517413. PMID28775711.
^Lindley SE, Carlson EB, Benoit M (May 2004). "Basal and dexamethasone suppressed salivary cortisol concentrations in a community sample of patients with posttraumatic stress disorder". Biological Psychiatry. 55 (9): 940–5. doi:10.1016/j.biopsych.2003.12.021. PMID15110738. S2CID 31580825.
^"NIMH · Post Traumatic Stress Disorder Research Fact Sheet". National Institutes of Health. Archived from the original on 23 January 2014. Retrieved 29 January 2014.
^Bromis K, Calem M, Reinders AA, Williams SC, Kempton MJ (July 2018). "Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder". The American Journal of Psychiatry. 175 (10): 989–998. doi:10.1176/appi.ajp.2018.17111199. PMC6169727. PMID30021460.
^Liberzon I, Sripada CS (2008). "The functional neuroanatomy of PTSD: A critical review". Stress Hormones and Post Traumatic Stress Disorder Basic Studies and Clinical Perspectives. Progress in Brain Research. Vol. 167. pp. 151–69. doi:10.1016/S0079-6123(07)67011-3. ISBN 9780444531407. PMID18037013.
^Etkin A, Wager TD (October 2007). "Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia". The American Journal of Psychiatry. 164 (10): 1476–88. doi:10.1176/appi.ajp.2007.07030504. PMC3318959. PMID17898336.
^van der Kolk B (March 2000). "Posttraumatic stress disorder and the nature of trauma". Dialogues in Clinical Neuroscience. 2 (1): 7–22. doi:10.31887/DCNS.2000.2.1/bvdkolk. PMC3181584. PMID22034447.
^Stein MB, Paulus MP (December 2009). "Imbalance of approach and avoidance: the yin and yang of anxiety disorders". Biological Psychiatry. 66 (12): 1072–4. doi:10.1016/j.biopsych.2009.09.023. PMC2825567. PMID19944792.
^Goodkind M, Etkin A. "Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders". In Sklar P, Buxbaum J, Nestler E, Charney D (eds.). Neurobiology of Mental Illness (5th ed.). Oxford University Press.
^Carlson, Neil R. (2007). Physiology of Behavior (9 ed.). Pearson Education, Inc.[full citation needed]
^Jatzko A, Rothenhöfer S, Schmitt A, Gaser C, Demirakca T, Weber-Fahr W, Wessa M, Magnotta V, Braus DF (August 2006). "Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods" (PDF). Journal of Affective Disorders. 94 (1–3): 121–6. doi:10.1016/j.jad.2006.03.010. PMID16701903. Archived (PDF) from the original on 19 October 2013.
^Neumeister A, Seidel J, Ragen BJ, Pietrzak RH (January 2015). "Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder". Psychoneuroendocrinology. 51: 577–84. doi:10.1016/j.psyneuen.2014.10.012. PMC4268027. PMID25456347.
^Shura, Robert D.; Epstein, Erica L.; Ord, Anna S.; Martindale, Sarah L.; Rowland, Jared A.; Brearly, Timothy W.; Taber, Katherine H. (1 September 2020). "Relationship between intelligence and posttraumatic stress disorder in veterans". Intelligence. 82: 101472. doi:10.1016/j.intell.2020.101472. ISSN 0160-2896.
^Boskovic, Irena; Merckelbach, Harald (2018). "Fake Posttraumatic Stress Disorder (PTSD) Costs Real Money". The Inquisitive Mind. 4 (36). Retrieved 30 September 2021.
^First MB (2013). DSM-5® Handbook of Differential Diagnosis. American Psychiatric Pub. p. 225. ISBN 9781585629985.
^"Trauma- and Stressor-Related Disorders", Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, 22 May 2013, doi:10.1176/appi.books.9780890425596.dsm07, ISBN 978-0890425558
^"PTSD Checklist for DSM-5 (PCL-5)". National Center for PTSD. 11 May 2017.
^Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL (December 2015). "The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): Development and Initial Psychometric Evaluation". Journal of Traumatic Stress. 28 (6): 489–98. doi:10.1002/jts.22059. PMID26606250.
^"Primary Care PTSD Screen for DSM-5 (PC-PTSD-5)". National Center for PTSD. 7 April 2017.
^"Child PTSD Symptom Scale". International Society for Traumatic Stress Studies.
^Foa EB, Johnson KM, Feeny NC, Treadwell KR (September 2001). "The child PTSD Symptom Scale: a preliminary examination of its psychometric properties". Journal of Clinical Child Psychology. 30 (3): 376–84. doi:10.1207/S15374424JCCP3003_9. PMID11501254. S2CID 9334984.
^"Child Trauma Screening Questionnaire". The National Child Traumatic Stress Network. 5 September 2013.
^Kenardy JA, Spence SH, Macleod AC (September 2006). "Screening for posttraumatic stress disorder in children after accidental injury". Pediatrics. 118 (3): 1002–9. doi:10.1542/peds.2006-0406. PMID16950991. S2CID 1320859.
^"UCLA Posttraumatic Stress Disorder Reaction Index". International Society for Traumatic Stress Studies.
^Elhai JD, Layne CM, Steinberg AM, Brymer MJ, Briggs EC, Ostrowski SA, Pynoos RS (February 2013). "Psychometric properties of the UCLA PTSD reaction index. part II: investigating factor structure findings in a national clinic-referred youth sample". Journal of Traumatic Stress. 26 (1): 10–8. doi:10.1002/jts.21755. PMID23417874.
^ abScheeringa M. "Young Child PTSD Screen". Tulane University. Retrieved 8 April 2018.
^Scheeringa MS, Haslett N (June 2010). "The reliability and criterion validity of the Diagnostic Infant and Preschool Assessment: a new diagnostic instrument for young children". Child Psychiatry and Human Development. 41 (3): 299–312. doi:10.1007/s10578-009-0169-2. PMC2862973. PMID20052532.
^Bovin MJ, Marx BP, Schnurr PP (2015). "Evolving DSM Diagnostic Criteria for PTSD: Relevance for Assessment and Treatment". Current Treatment Options in Psychiatry. 2 (1): 86–98. doi:10.1007/s40501-015-0032-y. [... the use of a multi-measure approach eliminates the bias associated with any given instrument ...."
^Ben Barnes J, Presseau C, Jordan AH, Kline NK, Young-McCaughan S, Keane TM, et al. (May 2019). "Common Data Elements in the Assessment of Military-Related PTSD Research Applied in the Consortium to Alleviate PTSD". Military Medicine. 184 (5–6): e218–e226. doi:10.1093/milmed/usy226. PMID30252077.
^Weathers, Frank W., Terence M. Keane, and Edna B. Foa, "Assessment and Diagnosis of Adults", in Effective Treatments for PTSD: Practice Guidelines from the International Society for Traumatic Stress Studies, 2nd ed., edited by Edna B. Foa, Terence M. Keane, and Matthew J. Friedman (New York: Guilford, 2009), 23–61. ("Thus, ample resources are now available to conduct psychometrically sound assessments of trauma survivors in any context, and it is no longer defensible for clinicians to do otherwise." (p. 25)).
^ ab"The ICD-10 Classification of Mental and Behavioural Disorders" (PDF). World Health Organization. pp. 120–121. Archived (PDF) from the original on 23 March 2014. Retrieved 29 January 2014.
^"WHO releases new International Classification of Diseases (ICD 11)". World Health Organization. Retrieved 15 November 2018.
^ abcdBrewin CR, Cloitre M, Hyland P, Shevlin M, Maercker A, Bryant RA, et al. (December 2017). "A review of current evidence regarding the ICD-11 proposals for diagnosing PTSD and complex PTSD" (PDF). Clinical Psychology Review. 58: 1–15. doi:10.1016/j.cpr.2017.09.001. PMID29029837.
^Herman JL (July 1992). "Complex PTSD: A syndrome in survivors of prolonged and repeated trauma". Journal of Traumatic Stress. 5 (3): 377–391. doi:10.1007/BF00977235. S2CID 189943097.
^Herman JL (1997). Trauma and Recovery (2nd ed.). New York: Basic Books. pp. 119–122. ISBN 978-0-465-08730-3.
^Carlier IV, Lamberts RD, van Uchelen AJ, Gersons BP (1998). "Disaster-related post-traumatic stress in police officers: A field study of the impact of debriefing". Stress Medicine. 14 (3): 143–8. doi:10.1002/(SICI)1099-1700(199807)14:3<143::AID-SMI770>3.0.CO;2-S.
^Mayou RA, Ehlers A, Hobbs M (June 2000). "Psychological debriefing for road traffic accident victims. Three-year follow-up of a randomised controlled trial". The British Journal of Psychiatry. 176 (6): 589–93. doi:10.1192/bjp.176.6.589. PMID10974967.
^ abRoberts NP, Kitchiner NJ, Kenardy J, Robertson L, Lewis C, Bisson JI (August 2019). "Multiple session early psychological interventions for the prevention of post-traumatic stress disorder". The Cochrane Database of Systematic Reviews. 8: CD006869. doi:10.1002/14651858.CD006869.pub3. PMC6699654. PMID31425615.
^Assessment and Management of Conditions Specifically Related to Stress(PDF). Geneva: World Health Organization. 2013. ISBN 978-92-4-150593-2. Archived (PDF) from the original on 1 February 2014. Retrieved 29 January 2014.
^Amos T, Stein DJ, Ipser JC (July 2014). "Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews. 7 (7): CD006239. doi:10.1002/14651858.CD006239.pub2. PMID25001071.
^ abGartlehner G, Forneris CA, Brownley KA, Gaynes BN, Sonis J, Coker-Schwimmer E, Jonas DE, Greenblatt A, Wilkins TM, Woodell CL, Lohr KN (2013). Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma. Agency for Healthcare Research and Quality (US). PMID23658936.
^Feldner MT, Monson CM, Friedman MJ (January 2007). "A critical analysis of approaches to targeted PTSD prevention: current status and theoretically derived future directions". Behavior Modification. 31 (1): 80–116. CiteSeerX10.1.1.595.9186. doi:10.1177/0145445506295057. PMID17179532. S2CID 44619491.
^Rose S, Bisson J, Churchill R, Wessely S (2002). "Psychological debriefing for preventing post traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews (2): CD000560. doi:10.1002/14651858.CD000560. PMC7032695. PMID12076399.
^"Psychological Debriefing for Post-Traumatic Stress Disorder". www.div12.org. Society of Clinical Psychology: Division 12 of The American Psychological Association. 19 August 2014. Retrieved 9 September 2017.
^Wiseman T, Foster K, Curtis K (November 2013). "Mental health following traumatic physical injury: an integrative literature review". Injury. 44 (11): 1383–90. doi:10.1016/j.injury.2012.02.015. PMID22409991.
^Kassam-Adams N, Marsac ML, Hildenbrand A, Winston F (December 2013). "Posttraumatic stress following pediatric injury: update on diagnosis, risk factors, and intervention". JAMA Pediatrics. 167 (12): 1158–65. doi:10.1001/jamapediatrics.2013.2741. PMID24100470.
^Powers MB, Halpern JM, Ferenschak MP, Gillihan SJ, Foa EB (August 2010). "A meta-analytic review of prolonged exposure for posttraumatic stress disorder". Clinical Psychology Review. 30 (6): 635–41. doi:10.1016/j.cpr.2010.04.007. PMID20546985.
^Guideline Development Panel for the Treatment of PTSD in Adults (2017). Clinical Practice Guideline for the Treatment of Posttraumatic Stress Disorder (PTSD) in Adults(PDF). Washington, D.C.: American Psychological Association. pp. ES–2.
^ abLee CW, Cuijpers P (June 2013). "A meta-analysis of the contribution of eye movements in processing emotional memories". Journal of Behavior Therapy and Experimental Psychiatry (Submitted manuscript). 44 (2): 231–9. doi:10.1016/j.jbtep.2012.11.001. PMID23266601.
^Cahill SP, Foa EB (2004). Taylor S (ed.). Advances in the Treatment of Posttraumatic Stress Disorder: Cognitive-behavioral perspectives. New York: Springer. pp. 267–313.
^VA/DOD Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder and Acute Stress Disorder(PDF). United States Department of Veterans Affairs. 2017. pp. 46–47.
^ abSuomi A, Evans L, Rodgers B, Taplin S, Cowlishaw S (December 2019). "Couple and family therapies for post-traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews. 2019 (12): CD011257. doi:10.1002/14651858.CD011257.pub2. PMC6890534. PMID31797352.
^Seidler GH, Wagner FE (November 2006). "Comparing the efficacy of EMDR and trauma-focused cognitive-behavioral therapy in the treatment of PTSD: a meta-analytic study". Psychological Medicine. 36 (11): 1515–22. doi:10.1017/S0033291706007963. PMID16740177. S2CID 39751799.
^ abMoreno-Alcázar A, Treen D, Valiente-Gómez A, Sio-Eroles A, Pérez V, Amann BL, Radua J (2017). "Efficacy of Eye Movement Desensitization and Reprocessing in Children and Adolescent with Post-traumatic Stress Disorder: A Meta-Analysis of Randomized Controlled Trials". Frontiers in Psychology. 8: 1750. doi:10.3389/fpsyg.2017.01750. PMC5641384. PMID29066991.
^Rolfsnes ES, Idsoe T (April 2011). "School-based intervention programs for PTSD symptoms: a review and meta-analysis". Journal of Traumatic Stress. 24 (2): 155–65. doi:10.1002/jts.20622. PMID21425191.
^ abForman-Hoffman, Valerie; Cook Middleton, Jennifer; Feltner, Cynthia; Gaynes, Bradley N.; Palmieri Weber, Rachel; Bann, Carla; Viswanathan, Meera; Lohr, Kathleen N.; Baker, Claire; Green, Joshua (17 May 2018). "Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update". Agency for Healthcare Research and Quality. doi:10.23970/ahrqepccer207.
^"Treatment of PTSD – PTSD: National Center for PTSD". U.S. Department of Veterans Affairs. 26 May 2016. Archived from the original on 1 December 2016.
^"PTSD Treatment Options". Defense Centers of Excellence. 23 November 2016. Archived from the original on 30 November 2016.
^"Cognitive Behavioral Therapy (CBT) for Treatment of PTSD". www.apa.org. Archived from the original on 9 January 2018. Retrieved 8 January 2018.
^"Treatment of PTSD - PTSD". National Center for PTSD. Retrieved 8 January 2018.
^Lewis, Catrin; Roberts, Neil P.; Bethell, Andrew; Robertson, Lindsay; Bisson, Jonathan I. (14 December 2018). "Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults". The Cochrane Database of Systematic Reviews. 12: CD011710. doi:10.1002/14651858.CD011710.pub2. ISSN 1469-493X. PMC6516951. PMID30550643.
^Grohol JM (17 May 2016). "What Is Exposure Therapy?". Psychcentral.com. Archived from the original on 11 August 2010. Retrieved 14 July 2010.
^Joseph JS, Gray MJ (2008). "Exposure Therapy for Posttraumatic Stress Disorder" (PDF). Journal of Behavior Analysis of Offender and Victim: Treatment and Prevention. 1 (4): 69–80. doi:10.1037/h0100457. Archived from the original (PDF) on 29 December 2010. Retrieved 10 May 2010.
^Ursano RJ, Bell C, Eth S, Friedman M, Norwood A, Pfefferbaum B, Pynoos JD, Zatzick DF, Benedek DM, McIntyre JS, Charles SC, Altshuler K, Cook I, Cross CD, Mellman L, Moench LA, Norquist G, Twemlow SW, Woods S, Yager J (November 2004). "Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder". The American Journal of Psychiatry. 161 (11 Suppl): 3–31. PMID15617511.
^Committee on Treatment of Posttraumatic Stress Disorder, Institute of Medicine: Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. Washington, D.C.: National Academies Press. 2008. ISBN 978-0-309-10926-0.[page needed]
^"Prolonged Exposure Therapy". PTSD: National Center for PTSD. U.S. Department of Veteran Affairs. 29 September 2009. Archived from the original on 14 November 2009. Retrieved 14 July 2010.
^Karlin BE, Ruzek JI, Chard KM, Eftekhari A, Monson CM, Hembree EA, Resick PA, Foa EB (December 2010). "Dissemination of evidence-based psychological treatments for posttraumatic stress disorder in the Veterans Health Administration". Journal of Traumatic Stress. 23 (6): 663–73. doi:10.1002/jts.20588. PMID21171126.
^Mulick PS, Landes S, Kanter JW (2005). "Contextual Behavior Therapies in the Treatment of PTSD: A Review" (PDF). International Journal of Behavioral Consultation and Therapy. 1 (3): 223–228. CiteSeerX10.1.1.625.4407. doi:10.1037/h0100747.
^Hassija CM, Gray MJ (2007). "Behavioral Interventions for Trauma and Posttraumatic Stress Disorder". International Journal of Behavioral Consultation and Therapy. 3 (2): 166–175. doi:10.1037/h0100797.
^Mulick PS, Naugle AE (2009). "Behavioral Activation in the Treatment of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder". International Journal of Behavioral Consultation and Therapy. 5 (2): 330–339. doi:10.1037/h0100892.
^ abShapiro F (April 1989). "Efficacy of the eye movement desensitization procedure in the treatment of traumatic memories". Journal of Traumatic Stress. 2 (2): 199–223. doi:10.1002/jts.2490020207.
^Shapiro F, Maxfield L (August 2002). "Eye Movement Desensitization and Reprocessing (EMDR): information processing in the treatment of trauma". Journal of Clinical Psychology. 58 (8): 933–46. doi:10.1002/jclp.10068. PMID12115716.
^ abThe Management of Post-Traumatic Stress Working Group (2010). "VA/DoD clinical practice guideline for management of post-traumatic stress". Department of Veterans Affairs, Department of Defense. p. Version 2.0. Archived from the original on 30 May 2013. Retrieved 2 June 2013.
^ abcGillies D, Taylor F, Gray C, O'Brien L, D'Abrew N (December 2012). "Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents". The Cochrane Database of Systematic Reviews. 12: CD006726. doi:10.1002/14651858.CD006726.pub2. hdl:1959.13/1311467. PMID23235632.
^ abJeffries FW, Davis P (May 2013). "What is the role of eye movements in eye movement desensitization and reprocessing (EMDR) for post-traumatic stress disorder (PTSD)? a review". Behavioural and Cognitive Psychotherapy. 41 (3): 290–300. doi:10.1017/S1352465812000793. PMID23102050. S2CID 33309479.
^ abcdefJonas DE, Cusack K, Forneris CA (April 2013). Psychological and pharmacological treatments for adults with posttraumatic stress disorder (PTSD). Comparative Effectiveness Reviews No. 92. Rockville, MD: Agency for Healthcare Research and Quality. PMID23658937. Archived from the original on 18 January 2017.
^Brewin CR, Andrews B, Valentine JD (October 2000). "Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults". Journal of Consulting and Clinical Psychology. 68 (5): 748–66. doi:10.1037/0022-006X.68.5.748. PMID11068961.
^Ozer EJ, Best SR, Lipsey TL, Weiss DS (January 2003). "Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis". Psychological Bulletin. 129 (1): 52–73. doi:10.1037/0033-2909.129.1.52. PMID12555794.
^Weissman MM, Markowitz JC, Klerman GL (2007). Clinician's Quick Guide to Interpersonal Psychotherapy. New York: Oxford University Press.[page needed]
^Bleiberg KL, Markowitz JC (January 2005). "A pilot study of interpersonal psychotherapy for posttraumatic stress disorder". The American Journal of Psychiatry. 162 (1): 181–3. doi:10.1176/appi.ajp.162.1.181. PMID15625219.
^"Trauma and PTSD Program – Columbia University Department of Psychiatry". Columbiatrauma.org. Archived from the original on 1 February 2014. Retrieved 29 January 2014.[full citation needed]
^Markowitz JC, Milrod B, Bleiberg K, Marshall RD (March 2009). "Interpersonal factors in understanding and treating posttraumatic stress disorder". Journal of Psychiatric Practice. 15 (2): 133–40. doi:10.1097/01.pra.0000348366.34419.28. PMC2852131. PMID19339847.
^Markowitz JC (October 2010). "IPT and PTSD". Depression and Anxiety. 27 (10): 879–81. doi:10.1002/da.20752. PMC3683871. PMID20886608.
^Krystal JH, Neumeister A (October 2009). "Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience". Brain Research. 1293: 13–23. doi:10.1016/j.brainres.2009.03.044. PMC2761677. PMID19332037.
^ abJeffreys M, Capehart B, Friedman MJ (2012). "Pharmacotherapy for posttraumatic stress disorder: review with clinical applications". Journal of Rehabilitation Research and Development. 49 (5): 703–15. doi:10.1682/JRRD.2011.09.0183. PMID23015581. While evidence-based, trauma-focused psychotherapy is the preferred treatment for PTSD, pharmacotherapy is also an important treatment option. First-line pharmacotherapy agents include selective serotonin reuptake inhibitors and the selective serotonin-norepinephrine reuptake inhibitor venlafaxine.
^Stein DJ, Ipser JC, Seedat S (January 2006). "Pharmacotherapy for post traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews (1): CD002795. doi:10.1002/14651858.CD002795.pub2. PMC6993948. PMID16437445.
^Puetz TW, Youngstedt SD, Herring MP (28 May 2015). Hashimoto K (ed.). "Effects of Pharmacotherapy on Combat-Related PTSD, Anxiety, and Depression: A Systematic Review and Meta-Regression Analysis". PLOS ONE. 10 (5): e0126529. Bibcode:2015PLoSO..1026529P. doi:10.1371/journal.pone.0126529. PMC4447407. PMID26020791. The cumulative evidence summarized in this review indicates that pharmacotherapy significantly reduces PTSD, anxiety, and depressive symptom severity among combat veterans with PTSD. The magnitude of the overall effects of pharmacotherapy on PTSD (Δ = 0.38), anxiety (Δ = 0.42), and depressive symptoms (Δ = 0.52) were moderate...
^Kapfhammer HP (June 2014). "Patient-reported outcomes in post-traumatic stress disorder. Part II: focus on pharmacological treatment". Dialogues in Clinical Neuroscience (in English, Spanish, and French). 16 (2): 227–37. doi:10.31887/DCNS.2014.16.2/hkapfhammer. PMC4140515. PMID25152660.
^Jain S, Greenbaum MA, Rosen C (February 2012). "Concordance between psychotropic prescribing for veterans with PTSD and clinical practice guidelines". Psychiatric Services. 63 (2): 154–60. doi:10.1176/appi.ps.201100199. PMID22302333.
^Auxéméry Y (October 2012). "[Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context]". L'Encephale (in French). 38 (5): 373–80. doi:10.1016/j.encep.2011.12.003. PMID23062450.
^Kapfhammer HP (December 2008). "[Therapeutic possibilities after traumatic experiences]". Psychiatria Danubina. 20 (4): 532–45. PMID19011595.
^Reist, C (2005). Post-traumatic Stress Disorder. Compendia, Build ID: F000005, published by Epocrates.com
^Maxmen JS, Ward NG (2002). Psychotropic drugs: fast facts (3rd ed.). New York: W. W. Norton. p. 349. ISBN 978-0-393-70301-6.
^Martényi F (March 2005). "[Three paradigms in the treatment of posttraumatic stress disorder]". Neuropsychopharmacologia Hungarica. 7 (1): 11–21. PMID16167463.
^ abVeterans Affairs and Department of Defense clinical practice guideline for management of post-traumatic stress. VA/DoD. 2010.
^Bandelow B, Zohar J, Hollander E, Kasper S, Möller HJ, Zohar J, Hollander E, Kasper S, Möller HJ, Bandelow B, Allgulander C, Ayuso-Gutierrez J, Baldwin DS, Buenvicius R, Cassano G, Fineberg N, Gabriels L, Hindmarch I, Kaiya H, Klein DF, Lader M, Lecrubier Y, Lépine JP, Liebowitz MR, Lopez-Ibor JJ, Marazziti D, Miguel EC, Oh KS, Preter M, Rupprecht R, Sato M, Starcevic V, Stein DJ, van Ameringen M, Vega J (2008). "World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision". The World Journal of Biological Psychiatry. 9 (4): 248–312. doi:10.1080/15622970802465807. PMID18949648.
^Green B (July 2014). "Prazosin in the treatment of PTSD". Journal of Psychiatric Practice. 20 (4): 253–9. doi:10.1097/01.pra.0000452561.98286.1e. PMID25036580. S2CID 40069887.
^Singh B, Hughes AJ, Mehta G, Erwin PJ, Parsaik AK (July 2016). "Efficacy of Prazosin in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis". The Primary Care Companion for CNS Disorders. 18 (4). doi:10.4088/PCC.16r01943. PMID27828694.
^Griffin GD, Charron D, Al-Daccak R (November 2014). "Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis". Clinical & Translational Immunology. 3 (11): e27. doi:10.1038/cti.2014.26. PMC4255796. PMID25505957.
^Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, et al. (December 2019). "Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis". The Lancet. Psychiatry. 6 (12): 995–1010. doi:10.1016/S2215-0366(19)30401-8. PMC6949116. PMID31672337.
^O'Neil ME, Nugent SM, Morasco BJ, Freeman M, Low A, Kondo K, et al. (September 2017). "Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review". Annals of Internal Medicine. 167 (5): 332–340. doi:10.7326/M17-0477. PMID28806794.
^Betthauser K, Pilz J, Vollmer LE (August 2015). "Use and effects of cannabinoids in military veterans with posttraumatic stress disorder". American Journal of Health-System Pharmacy (Review). 72 (15): 1279–84. doi:10.2146/ajhp140523. PMID26195653.
^"Long-term Nabilone Use: A Review of the Clinical Effectiveness and Safety". CADTH Rapid Response Reports. October 2015. PMID26561692.
^Gregg K (13 July 2016). "Raimondo signs law allowing marijuana for treatment of PTSD". Providence Journal. Archived from the original on 16 August 2016. Retrieved 18 August 2016.
^Lawrence S, De Silva M, Henley R (January 2010). Lawrence S (ed.). "Sports and games for post-traumatic stress disorder (PTSD)". The Cochrane Database of Systematic Reviews (1): CD007171. doi:10.1002/14651858.CD007171.pub2. PMC7390394. PMID20091620. Archived from the original on 1 February 2014.
^Jankowski K. "PTSD and physical health". Information on trauma and PTSD for professionals, National Center for PTSD. U.S. Department of Veterans Affairs. Archived from the original on 30 July 2009. Retrieved 8 June 2013.
^U.S. Department of Veterans Affairs. "Lifestyle Changes Recommended for PTSD Patients". Information on trauma and PTSD for veterans, general public and family from the National Center for PTSD. U.S. Department of Veterans Affairs. Archived from the original on 31 July 2009. Retrieved 8 June 2013.
^ abWethington HR, Hahn RA, Fuqua-Whitley DS, Sipe TA, Crosby AE, Johnson RL, Liberman AM, Mościcki E, Price LN, Tuma FK, Kalra G, Chattopadhyay SK (September 2008). "The effectiveness of interventions to reduce psychological harm from traumatic events among children and adolescents: a systematic review". American Journal of Preventive Medicine. 35 (3): 287–313. doi:10.1016/j.amepre.2008.06.024. PMID18692745. Archived from the original on 3 February 2014.
^Fletcher KE, Barkley RA (2003). "7". In Mash EJ (ed.). Child psychopathology (2nd ed.). New York: Guilford Press. pp. 330–371. ISBN 978-1-57230-609-7.
^"Marine Corps Offers Yoga, Massages to Marriages Strained by War". Fox News Channel. Associated Press. 2 April 2008. Archived from the original on 5 April 2008. Retrieved 3 April 2008.
^Sweeney H (6 November 2015). "Private Hospital Network to Help VA with Mental Health Care for Vets". Military.com. Archived from the original on 30 March 2017. Retrieved 29 March 2017.
^Cullen K (2 May 2016). "Covering all the bases for veterans". The Boston Globe. Archived from the original on 30 March 2017. Retrieved 29 March 2017.
^FDA approves Apple Watch app NightWare to treat PTSD nightmares
^"Mortality and Burden of Disease Estimates for WHO Member States in 2004". World Health Organization.
^Brunet A, Akerib V, Birmes P (August 2007). "Don't throw out the baby with the bathwater (PTSD is not overdiagnosed)". Canadian Journal of Psychiatry. 52 (8): 501–2, discussion 503. doi:10.1177/070674370705200805. PMID17955912.
^Kilpatrick DG, Resnick HS, Milanak ME, Miller MW, Keyes KM, Friedman MJ (October 2013). "National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria". Journal of Traumatic Stress. 26 (5): 537–47. doi:10.1002/jts.21848. PMC4096796. PMID24151000.
^ ab"Mortality and Burden of Disease Estimates for WHO Member States: Persons, all ages (2004)" (xls). World Health Organization. 2004. Retrieved 12 November 2009.
^ ab"Mortality and Burden of Disease Estimates for WHO Member States: Females, all ages (2004)" (xls). World Health Organization. 2004. Retrieved 12 November 2009.
^ ab"Mortality and Burden of Disease Estimates for WHO Member States: Males, all ages (2004)" (xls). World Health Organization. 2004. Retrieved 12 November 2009.
^ abKoenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ, Karam EG, Meron Ruscio A, Benjet C, Scott K, Atwoli L, Petukhova M, Lim CC, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bunting B, Ciutan M, de Girolamo G, Degenhardt L, Gureje O, Haro JM, Huang Y, Kawakami N, Lee S, Navarro-Mateu F, Pennell BE, Piazza M, Sampson N, Ten Have M, Torres Y, Viana MC, Williams D, Xavier M, Kessler RC (October 2017). "Posttraumatic stress disorder in the World Mental Health Surveys". Psychological Medicine. 47 (13): 2260–2274. doi:10.1017/S0033291717000708. PMC6034513. PMID28385165.
^Sher L (August 2010). "Neurobiology of suicidal behavior in post-traumatic stress disorder". Expert Review of Neurotherapeutics. 10 (8): 1233–5. doi:10.1586/ern.10.114. PMID20662745. S2CID 5900319.
^Mintz S (2007). "The War's Costs". Digital History. Archived from the original on 7 September 2003.
^Price JL. "Findings from the National Vietnam Veterans' Readjustment Study – Factsheet". United States Department of Veterans Affairs. National Center for PTSD. Archived from the original on 30 April 2009.
^"Psychological Costs of War: Military Combat and Mental Health". Journalistsresource.org. 27 February 2012. Archived from the original on 2 February 2014. Retrieved 29 January 2014.
^Spoont M, Arbisi P, Fu S, Greer N, Kehle-Forbes S, Meis L, Rutks I, Wilt TJ (January 2013). Screening for Post-Traumatic Stress Disorder (PTSD) in Primary Care: A Systematic Review. VA Evidence-based Synthesis Program Reports. Department of Veterans Affairs. PMID23487872.
^Meade BJ, Glenn MK, Wirth O (29 March 2013). "Mission Critical: Getting Vets With PTSD Back to Work". NIOSH: Workplace Safety and Health. Medscape & NIOSH. Archived from the original on 16 March 2016.
^ abcdefLowell A, Suarez-Jimenez B, Helpman L, Zhu X, Durosky A, Hilburn A, Schneier F, Gross R, Neria Y (March 2018). "9/11-related PTSD among highly exposed populations: a systematic review 15 years after the attack". Psychological Medicine. 48 (4): 537–553. doi:10.1017/S0033291717002033. PMC5805615. PMID28805168.
^ abcdPerrin MA, DiGrande L, Wheeler K, Thorpe L, Farfel M, Brackbill R (September 2007). "Differences in PTSD prevalence and associated risk factors among World Trade Center disaster rescue and recovery workers". The American Journal of Psychiatry. 164 (9): 1385–94. doi:10.1176/appi.ajp.2007.06101645. PMID17728424.
^ abcdeStellman JM, Smith RP, Katz CL, Sharma V, Charney DS, Herbert R, Moline J, Luft BJ, Markowitz S, Udasin I, Harrison D, Baron S, Landrigan PJ, Levin SM, Southwick S (September 2008). "Enduring mental health morbidity and social function impairment in world trade center rescue, recovery, and cleanup workers: the psychological dimension of an environmental health disaster". Environmental Health Perspectives. 116 (9): 1248–53. doi:10.1289/ehp.11164. PMC2535630. PMID18795171.
^"VA Compensation Rate Table". Department of Veterans Affairs. Archived from the original on 3 November 2012. Retrieved 20 October 2012.
^"Access VA Health Benefits". Department of Veterans Affairs. Archived from the original on 16 October 2012. Retrieved 20 October 2012.
^"VA Vocational Rehabilitation". Department of Veterans Affairs. Archived from the original on 19 October 2012. Retrieved 20 October 2012.
^"Vet Success". Department of Veterans Affairs + State Government Veterans Agencies. Archived from the original on 19 October 2012. Retrieved 20 October 2012.
^"Independent Living Support for Veterans". Department of Veterans Affairs. Archived from the original on 24 October 2012. Retrieved 20 October 2012.
^"Veterans Benefits". Veterans Benefits Administration. Archived from the original on 26 November 2012. Retrieved 30 November 2012.
^al-Shawi A (February 2017). "Posttraumatic Stress Disorder among Youth in Iraq, Short Systemic Reviews". austinpublishinggroup.com. Journal of Community Medicine And Healthcare. Retrieved 5 July 2019.
^Dixon L (28 February 2009). "Lance Corporal Johnson Beharry accuses Government of neglecting soldiers". The Times. London. Retrieved 29 August 2009. (subscription required)
^"UK | Full interview: L/Cpl Johnson Beharry". BBC News. 28 February 2009. Archived from the original on 19 February 2014. Retrieved 29 August 2009.
^"The Operational Stress Injury Social Support (OSISS) Program for Canadian Veterans". Archived from the original on 6 July 2011. See also "Evaluation of the OSISS Peer Support Network" (PDF). Dept. of National Defence and Veterans Affairs Canada. January 2005. Archived (PDF) from the original on 30 January 2014.
^Heber A, Grenier S, Richardson D, Darte K (2006). "Combining Clinical Treatment and Peer Support: A Unique Approach to Overcoming Stigma and Delivering Care" (PDF). Human Dimensions in Military Operations – Military Leaders' Strategies for Addressing Stress and Psychological Support. Neuilly-sur-Seine, France: Canadian Department Of National Defence. Archived from the original on 7 October 2012. Retrieved 30 January 2014.
^Richardson JD, Darte K, Grenier S, English A, Sharpe J (2008). "Operational Stress Injury Social Support: a Canadian innovation in professional peer support". Canadian Military Journal. 9 (1): 57–64. Archived from the original on 21 December 2013. Retrieved 30 January 2014.
^"The New Veterans Charter for CF Veterans and their Families". Vac-Acc.Gc.Ca. 12 July 2006. Archived from the original on 19 June 2006. Retrieved 29 August 2009.
^ abAndreasen NC (October 2010). "Posttraumatic stress disorder: a history and a critique". Annals of the New York Academy of Sciences. 1208 (Psychiatric and Neurologic Aspects of War): 67–71. Bibcode:2010NYASA1208...67A. doi:10.1111/j.1749-6632.2010.05699.x. PMID20955327. S2CID 42645212.
^ abAmerican Psychiatric Association (1952). Diagnostic and Statistical Manual. American Psychiatric Association Mental Hospital Service. p. 326.3. ISBN 978-0890420171.
^Jones DR, Fischer JR (1 April 1982). "Emotional Effects on USAF Personnel of Recovering and Identifying Victims from Jonestown, Guyana" (PDF).
^ abShalev AY, Yehuda R, McFarlane AC (2000). International handbook of human response to trauma. New York: Kluwer Academic/Plenum Press. ISBN 978-0-306-46095-1.[page needed];on-line.
^"International Statistical Classification of Diseases and Related Health Problems 10th Revision Version for 2007". World Health Organization (UN). 2007. Archived from the original on 5 December 2014. Retrieved 3 October 2011.
^"When trauma tips you over: PTSD Part 1". All in the Mind. Australian Broadcasting Commission. 9 October 2004. Archived from the original on 3 June 2008.
^Andreasen NC (19 February 2004). Brave New Brain: Conquering Mental Illness in the Era of the Genome. New York: Oxford University Press. p. 303. ISBN 978-0-19-516728-3.
^Jones JA (2013). "From Nostalgia to Post-Traumatic Stress Disorder: A Mass Society Theory of Psychological Reactions to Combat". Inquiries Journal. 5 (2): 1–3. Archived from the original on 17 February 2014.
^"Henry IV, Part I, Act II, Scene 3 : |: Open Source Shakespeare". Opensourceshakespeare.org. Archived from the original on 27 March 2014. Retrieved 30 January 2014.
^Shay J (1994). Achilles in Vietnam: Combat Trauma and the Undoing of Character. Scribner. pp. 165–66.
^"World War One – A New Kind of War, Part II". www.ralphmag.org. Archived from the original on 3 March 2016., From 14 – 18 Understanding the Great War, by Stéphane Audoin-Rouzeau, Annette Becker[incomplete short citation]
^Möbius S (2015). "Im Kugelhagel der Musketen". Damals (in German). Vol. 47, no. 12. pp. 64–69.
^"Ancient Assyrian Soldiers Were Haunted by War, Too".
^Shay J (2000). "Killing rage: physis or nomos—or both". War and Violence in Ancient Greece. Duckworth and the Classical Press of Wales. pp. 31–56. ISBN 0715630466.
^"Civilian PTSD Symptoms and Risk for Involvement in the Criminal Justice System". Journal of the Academy of Psychiatry and the Law. 40 (4): 522–529. 1 December 2012. ISSN 1093-6793. Retrieved 29 November 2014.
^Holmstrom LL, Burgess AW (1978). The Victim of Rape: Institutional Reactions. Wiley-Interscience. ISBN 978-0471407850.
^Scrignar CB. "PTSD, the Traumatic Principle and Lawsuits". Psychiatric Times. Retrieved 25 June 2018.
^"Search results: 'post-traumatic stress disorder' in the title of a journal article". U.S. National Library of Medicine. Archived from the original on 14 May 2016. Retrieved 21 January 2015.
^Thompson M (2011). "The Disappearing 'Disorder': Why PTSD is becoming PTS". Time. Retrieved 3 October 2018.
^Peters M (19 May 2017). "George Carlin: Euphemism Fighter Supreme". McSweeny's. Retrieved 3 April 2019.
^Fodor KE, Unterhitzenberger J, Chou CY, Kartal D, Leistner S, Milosavljevic M, Nocon A, Soler L, White J, Yoo S, Alisic E (2014). "Is traumatic stress research global? A bibliometric analysis". European Journal of Psychotraumatology. 5 (1): 23269. doi:10.3402/ejpt.v5.23269. PMC3930940. PMID24563730.
^ abOjo JO, Greenberg MB, Leary P, Mouzon B, Bachmeier C, Mullan M, Diamond DM, Crawford F (December 2014). "Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury". Frontiers in Behavioral Neuroscience. 8: 213. doi:10.3389/fnbeh.2014.00213. PMC4067099. PMID25002839.
^Poulos AM, Reger M, Mehta N, Zhuravka I, Sterlace SS, Gannam C, Hovda DA, Giza CC, Fanselow MS (August 2014). "Amnesia for early life stress does not preclude the adult development of posttraumatic stress disorder symptoms in rats". Biological Psychiatry. 76 (4): 306–14. doi:10.1016/j.biopsych.2013.10.007. PMC3984614. PMID24231200.
^Hill MN, Patel S (October 2013). "Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses". Biology of Mood & Anxiety Disorders. 3 (1): 19. doi:10.1186/2045-5380-3-19. PMC3817535. PMID24286185.
^Feldwisch-Drentrup H (July 2002). "New clues to why a French drug trial went horribly wrong". Science. Retrieved 11 December 2019.
^Mitchell JM, Bogenschutz M, Lilienstein A, et al. (2021). "MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study". Nature Medicine. 27 (6): 1025–1033. doi:10.1038/s41591-021-01336-3. PMC8205851. PMID33972795.
^Muthukumaraswamy, Suresh D.; Forsyth, Anna; Lumley, Thomas (2 September 2021). "Blinding and expectancy confounds in psychedelic randomized controlled trials". Expert Review of Clinical Pharmacology. 14 (9): 1133–1152. doi:10.1080/17512433.2021.1933434. ISSN 1751-2433. PMID34038314. S2CID 235215630.
^Burke, Matthew J.; Blumberger, Daniel M. (October 2021). "Caution at psychiatry's psychedelic frontier". Nature Medicine. 27 (10): 1687–1688. doi:10.1038/s41591-021-01524-1. ISSN 1078-8956. PMID34635858. S2CID 238635462.
^Halvorsen, Joar Øveraas; Naudet, Florian; Cristea, Ioana A. (October 2021). "Challenges with benchmarking of MDMA-assisted psychotherapy". Nature Medicine. 27 (10): 1689–1690. doi:10.1038/s41591-021-01525-0. ISSN 1078-8956. PMID34635857. S2CID 238636360.
^ abStraud CL, Siev J, Messer S, Zalta AK (October 2019). "Examining military population and trauma type as moderators of treatment outcome for first-line psychotherapies for PTSD: A meta-analysis". Journal of Anxiety Disorders. 67: 102133. doi:10.1016/j.janxdis.2019.102133. PMC6739153. PMID31472332.
^Hamblen JL, Norman SB, Sonis JH, Phelps AJ, Bisson JI, Nunes VD, et al. (September 2019). "A guide to guidelines for the treatment of posttraumatic stress disorder in adults: An update" (PDF). Psychotherapy. 56 (3): 359–373. doi:10.1037/pst0000231. PMID31282712. S2CID 195829939.
^Kline AC, Cooper AA, Rytwinksi NK, Feeny NC (February 2018). "Long-term efficacy of psychotherapy for posttraumatic stress disorder: A meta-analysis of randomized controlled trials". Clinical Psychology Review. 59: 30–40. doi:10.1016/j.cpr.2017.10.009. PMC5741501. PMID29169664.
^Goetter EM, Bui E, Ojserkis RA, Zakarian RJ, Brendel RW, Simon NM (October 2015). "A Systematic Review of Dropout From Psychotherapy for Posttraumatic Stress Disorder Among Iraq and Afghanistan Combat Veterans". Journal of Traumatic Stress. 28 (5): 401–9. doi:10.1002/jts.22038. PMID26375387.
^Merz J, Schwarzer G, Gerger H (June 2019). "Comparative Efficacy and Acceptability of Pharmacological, Psychotherapeutic, and Combination Treatments in Adults With Posttraumatic Stress Disorder: A Network Meta-analysis". JAMA Psychiatry. 76 (9): 904–913. doi:10.1001/jamapsychiatry.2019.0951. PMC6563588. PMID31188399.
^Forman-Hoffman V, Middleton JC, Feltner C, Gaynes BN, Weber RP, Bann C, et al. (2018). Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update. AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID30204376.
^Althobaiti S, Kazantzis N, Ofori-Asenso R, Romero L, Fisher J, Mills KE, Liew D (March 2020). "Efficacy of interpersonal psychotherapy for post-traumatic stress disorder: A systematic review and meta-analysis". Journal of Affective Disorders. 264: 286–294. doi:10.1016/j.jad.2019.12.021. PMID32056763. S2CID 211111940.
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