Prilep is a city in North Macedonia.

Prilep (Cyrillic: Прилеп) may also refer to:

• Lordship of Prilep, a successor-state of the Serbian Empire
• Prilep, Burgas Province, a village in the Burgas Province, Bulgaria
• Prilep, Dobrich Province, a village in the Dobrich Province, Bulgaria
• Prilep, Kosovo, a village in Kosovo
• Prilep Knoll, a hill in Graham Land, Antarctica
• Prilep Municipality, North Macedonia