The prion pseudoknot is predicted RNA pseudoknot structure found in prion protein mRNA.[1] It has been suggested that this element has a possible effect in prion protein translation.[2] The human prion protein gene contains 5 copies of a 24 nucleotide repeat that contains this structure.[2] The number of nucleotide repeats found in an organism may vary from one organism to another. Each species has a set number of nucleotide repeats, but when the organism deviates from this number, mutations in the prion genes may arise.[2] Human individuals that exhibit these mutations may be prone to developing prion diseases, such as Creutzfeldt-Jakob disease. [2]
Prion pseudoknot | |
---|---|
Identifiers | |
Symbol | Prion_pknot |
Rfam | RF00523 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Eukaryota |
SO | SO:0000233 |
PDB structures | PDBe |