In enzymology, a protein geranylgeranyltransferase type I (EC 2.5.1.59) is an enzyme that catalyzes the chemical reaction
CAAX-protein geranylgeranyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.59 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.
As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1S63, 1S64, 1SA4, 1SA5, 1TNB, 1TNO, 1TNU, 1TNY, 1TNZ, 1X81, 2BED, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, and 2IEJ.