RBP2 Knowpia

RBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RCQ, 2RCT, 4EDE, 4EEJ, 4EFG, 4EXZ, 4GKC, 4QYN, 4QYP, 4QZT, 4QZU, 4RUU, 4ZGU, 4ZH9, 4ZCB, 4ZH6, 4ZJ0, 4ZR2
Identifiers
Aliases	RBP2, CRABP-II, CCRBPII, RBPC2, retinol binding protein 2
External IDs	OMIM: 180280 MGI: 97877 HomoloGene: 3070 GeneCards: RBP2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	139,480,747 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	98,391,834 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; right lung; ; amniotic fluid; ; right uterine tube; ; upper lobe of left lung; ; rectum; ; corpus callosum; ; islet of Langerhans; ; gallbladder;
	Top expressed in
	duodenum; ; esophagus; ; pyloric antrum; ; jejunum; ; ileum; ; lip; ; mucous cell of stomach; ; yolk sac; ; corneal stroma; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; retinol binding; retinoid binding; retinal binding;
Cellular component	cytoplasm; cytosol;
Biological process	retinoid metabolic process; epidermis development; vitamin A metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	5948
	19660
	ENSG00000114113
	ENSMUSG00000032454
	P50120
	Q08652
	NM_004164
	NM_009034
	NP_004155
	NP_033060
	Wikidata
View/Edit Human	View/Edit Mouse

Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.^[5]^[6]^[7]

Function edit

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114113 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032454 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod. 10 (5): 1297–304. doi:10.1093/oxfordjournals.humrep.a136137. PMID 7657783.
^ De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 240–1. doi:10.1159/000015191. PMID 10072590. S2CID 22941923.
^ ^a ^b "Entrez Gene: RBP2 retinol binding protein 2, cellular".