RFX4 Knowpia

RFX4
Identifiers
Aliases	RFX4, NYD-SP10, regulatory factor X4
External IDs	OMIM: 603958 MGI: 1918387 HomoloGene: 31119 GeneCards: RFX4
Gene location (Human)
Chr.	Chromosome 12 (human)
End	106,762,803 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	84,742,402 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; internal globus pallidus; ; sperm; ; caudate nucleus; ; amygdala; ; nucleus accumbens; ; superior vestibular nucleus; ; ganglionic eminence; ; putamen; ; entorhinal cortex;
	Top expressed in
	spermatocyte; ; spermatid; ; suprachiasmatic nucleus; ; globus pallidus; ; seminiferous tubule; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; paraventricular nucleus of hypothalamus; ; mammillary body; ; urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; forebrain development; telencephalon development; dorsal spinal cord development; regulation of transcription, DNA-templated; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning; cerebellar cortex morphogenesis; midbrain development; positive regulation of transcription by RNA polymerase II; regulation of protein processing; transcription, DNA-templated; transcription by RNA polymerase II; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	5992
	71137
	ENSG00000111783
	ENSMUSG00000020037
	Q33E94
	Q7TNK1
	NM_213594; NM_001206691; NM_002920; NM_032491
	NM_001024918; NM_027689
	NP_001193620; NP_115880; NP_998759
	NP_001020089; NP_081965
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.^[5]^[6]^[7]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111783 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020037 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Emery P, Durand B, Mach B, Reith W (May 1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.
^ Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y (Jan 2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.
^ ^a ^b "Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)".