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Reidun Twarock

Summary

Reidun Twarock (German: [ˈʁaɪdɐn ˈtvæʁɔk][1]) is a German-born mathematical biologist at the University of York. She is known for developing mathematical models of viruses based on higher-dimensional lattices.[2][3]

Reidun Twarock
NationalityGerman
Alma materTechnische Universität Clausthal
Known forMathematical Biology, Virology, Bioinformatics
Scientific career
FieldsMathematician, Biologist
InstitutionsUniversity of York

Education edit

Twarock originally studied mathematical physics at the universities of Cologne and Bath. During her PhD at Technische Universität Clausthal she experimented with quantum mechanical models confined to the surface of a sphere.

Research edit

In the early 2000s, while thinking about the Penrose tiling and different ways of dividing the surface of a sphere, Twarock created a model describing the exceptional structure of papovaviridae.[4] Almost all icosahedral viruses have proteins on their capsids arranged in clusters of five and six, with a structure permitting at most 12 clusters of five, but papovaviridae, including HPV, have 72 clusters of five[5] This protein layout did not correspond to any spherical polyhedron known to mathematics.

After this, Twarock entered virology. The structure of the virus HK97 was exceptional too, not being modelled by any goldberg polyhedron. Mathematical virology had previously only studied the surfaces of virus, using models that were tilings of the 2-sphere; Twarock hoped to go further than this, to model the three-dimensional protein structure and interior of viruses where their genome is packaged.[6]

It was known that, using rotations, virus protein patterns could be generated from a single shape by making copies of it and moving them around in ways that preserve the symmetry. Twarock added an outward translation to this generating process, which created a quite complex patterns of points in 3D space. These patterns turned out to accurately predict the shape and size of the proteins, as well as the structure of packaged genetic material, for many viruses including Nodaviridae.[7]

The models turned out to be useful for studying the assembly of RNA viruses, which involves proteins binding to specific parts of the genome that end up in 3-dimensional locations[8] that can be determined mathematically.[9][10][11] More insights were gained using the "cut and project" method of generating penrose tilings. Her models can be thought of as squashed-down three dimensional pictures of the 6-demicubic honeycomb tiling, which is a six-dimensional version of the three-dimensional Tetrahedral-octahedral honeycomb. Different viruses are modelled by different subsets of the vertices of this lattice. The viruses appear to use these patterns because they are the most stable way of connecting multiple interacting layers that all have icosahedral symmetry.

Her work has applications to the study of nanomaterials.[12]

Awards and honours edit

  • She was awarded the 2018 IMA Gold Medal [13]

See also edit

References edit

  1. ^ "Virus Structure through a Mathematical Microscope by Reidun Twarock". YouTube. Retrieved 17 September 2020.
  2. ^ Stewart, Ian. The mathematics of life. Basic Books, 2011.
  3. ^ Cepelewicz, Jordana (19 July 2017), "The Illuminating Geometry of Viruses", Quanta Magazine
  4. ^ Twarock, R. (2004). "A tiling approach to virus capsid assembly explaining a structural puzzle in virology". Journal of Theoretical Biology. 226 (4). Elsevier BV: 477–482. Bibcode:2004JThBi.226..477T. doi:10.1016/j.jtbi.2003.10.006. ISSN 0022-5193. PMID 14759653.
  5. ^ Rayment, I.; Baker, T. S.; Caspar, D. L. D.; Murakami, W. T. (1982). "Polyoma virus capsid structure at 22.5 Å resolution". Nature. 295 (5845). Springer Science and Business Media LLC: 110–115. Bibcode:1982Natur.295..110R. doi:10.1038/295110a0. ISSN 0028-0836. PMC 4144041. PMID 6276752.
  6. ^ West, Mark (30 September 2007). "A symmetry approach to viruses". Plus Maths. plus magazine. Retrieved 30 November 2014.
  7. ^ Keef, T.; Twarock, R. (1 November 2008). "Affine extensions of the icosahedral group with applications to the three-dimensional organisation of simple viruses". Journal of Mathematical Biology. 59 (3). Springer Science and Business Media LLC: 287–313. doi:10.1007/s00285-008-0228-5. ISSN 0303-6812. PMID 18979101. S2CID 37042491.
  8. ^ Rolfsson, Óttar; Middleton, Stefani; Manfield, Iain W.; White, Simon J.; Fan, Baochang; Vaughan, Robert; Ranson, Neil A.; Dykeman, Eric; Twarock, Reidun; Ford, James; Cheng Kao, C.; Stockley, Peter G. (2016). "Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2". Journal of Molecular Biology. 428 (2). Elsevier BV: 431–448. doi:10.1016/j.jmb.2015.11.014. ISSN 0022-2836. PMC 4751978. PMID 26608810.
  9. ^ Self-Assembly of Viral Capsids via a Hamiltonian Paths Approach: The Case of Bacteriophage MS2
  10. ^ Twarock, Reidun; Valiunas, Motiejus; Zappa, Emilio (22 September 2015). "Orbits of crystallographic embedding of non-crystallographic groups and applications to virology" (PDF). Acta Crystallographica Section A. 71 (6). International Union of Crystallography (IUCr): 569–582. arXiv:1411.2115. doi:10.1107/s2053273315015326. ISSN 2053-2733. PMID 26522406. S2CID 36526939.
  11. ^ Zappa, Emilio; Dykeman, Eric C.; Twarock, Reidun (10 July 2014). "On the subgroup structure of the hyperoctahedral group in six dimensions". Acta Crystallographica Section A. 70 (5). International Union of Crystallography (IUCr): 417–428. arXiv:1402.3136. doi:10.1107/s2053273314007712. ISSN 2053-2733. PMC 4186354. PMID 25176990.
  12. ^ Know your onion, Vol 10, p. 244, April 2014
  13. ^ "IMA Gold Medal 2018 awarded to Professor Reidun Twarock". 14 August 2018. Retrieved 5 January 2022.

External links edit

  • "The York Research Database - Prof. Reidun Twarock". The University of York. Retrieved 29 February 2020.
  • "An Interview with Reidun Twarock FIMA". Institute of Mathematics. 12 October 2019. Retrieved 29 February 2020.
  • "Mathematics and the fight against viral infections - Professor Reidun Twarock". YouTube. University of York. 10 February 2016. Retrieved 29 February 2020.
  • "Geometry: A New Weapon in the Fight Against Viruses, Professor Reidun Twarock". Gresham College. 20 May 2015. Retrieved 29 February 2020.
  • "LMS Popular Lecture Series 2008, Know your Enemy, Dr Reidun Twarock". YouTube. London Mathematical Society. 15 May 2014. Retrieved 29 February 2020.
  • "Viruses under the Mathematical Microscope: Deciphering the Code of Viral Geometry". YouTube. Cambridge University. 10 May 2011. Retrieved 29 February 2020.

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