Rinaldo Piscicello was born in Naples in 1415 or 1416, the son of Nicola Piscicello and Maria d'Alagni.^[1] His mother was related to Lucrezia d'Alagni, the mistress of Alfonso V of Aragon, which likely helped his career in the church.^[1]

He became a prebendary and canon of Naples Cathedral.^[1] He later became vicar general of the cathedral chapter.^[1] He also became a protonotary apostolic.^[1]

On 12 May 1451 he was elected Archbishop of Naples.^[1] He rebuilt the cathedral of San Severo,^{[clarification needed]} which had been badly damaged by earthquakes in December 1456.

In the consistory of 17 December 1456, Pope Callixtus III made him a cardinal.^[1] He arrived in Rome on 20 March 1457 and received the red hat, and the titular church of Santa Cecilia in Trastevere, on 21 March 1457.^[1]

He died in Rome on 4 July 1457.^[1] In 1458, his body was transferred to Naples Cathedral, where he is buried.^[1]