The River Dene is a small river in Warwickshire, England.

Dene
Old Stratford and Midland Junction Railway bridge over the River Dene at Kineton.
Location
Country	England
County	Warwickshire
Physical characteristics
Source
• location	Burton Dassett Hills
Mouth	Avon
• location	Charlecote Park
• coordinates	52°12′16″N 1°37′23″W / 52.20444°N 1.62306°W / 52.20444; -1.62306

It is a tributary of the Avon, which it joins at Charlecote Park. The headwaters of the River Dene rise on the western slopes of the Burton Dassett Hills and flow westward towards Kineton. Five miles downstream of Kineton, the river turns abruptly north, flowing through the villages of Walton and Wellesbourne before joining the Avon.

To the west of Kineton, the Dene was followed, and bridged in numerous places, by the Stratford-upon-Avon and Midland Junction Railway. At Kineton can be seen the remains of four sets of sluice-gates, possibly used for flooding the land in the cultivation of osiers for use in basket making.