Summary
Robert W. Horne (21 January 1923 – 13 November 2010) was a British virologist and expert in electron microscopy.[1]
Life and academic career edit
Horne was raised in Montreal and served in the Royal Air Force during the Second World War.[1][2] He began his scientific career at the Cavendish Laboratory at the University of Cambridge, where he began working with transmission electron microscopes with Vernon Ellis Cosslett.[1] He received his master's and doctorate from the University of Cambridge.[2] In 1961, Horne moved to what was then the Institute of Animal Physiology (now the Babraham Institute), and in 1968 he moved again to what became the John Innes Centre, directed by Roy Markham. Horne remained there as a department head until retiring in 1982.[1] He continued working after his retirement as an honorary professor at the University of East Anglia.[1][2]
In addition to his scientific interests, Horne was a sailing enthusiast and an artist who focused on marine art.[1]
Research edit
Horne specialized in the use of electron microscopy to study viruses. In 1959, he and Sydney Brenner pioneered the technique of negative staining in electron microscopy and used it to study virus structure, beginning with bacteriophages.[1][3] With Peter Wildy and Willie Russell, Horne applied the technique to study the herpes simplex virus and the geometry of its capsid.[4][5] In the 1960s, Horne, André Michel Lwoff, and Paul Tournier developed early systems of viral taxonomy.[6][7][8] His work with Alec Bangham on phospholipids contributed to the discovery of liposomes.[1]
Horne wrote two books on virology and co-authored reference works in electron microscopy. He joined the editorial board of the journal Micron at its founding in 1969 and served as its editor-in-chief from 1978 to 1995.[1]
References edit
- ^ a b c d e f g h i Harris, J. Robin; Munn, Edward A. (July 2011). "An Appreciation: Robert (Bob) W. Horne (21st January 1923–13th November 2010)". Micron. 42 (5): 528–530. doi:10.1016/j.micron.2010.12.009. PMID 21534267.
- ^ a b c Horne, Robert (1991). "Viruses: architecture smaller than life". RSA Journal. 139 (5414): 929–35. JSTOR 41375434.
- ^ BRENNER, S; HORNE, RW (July 1959). "A negative staining method for high resolution electron microscopy of viruses". Biochimica et Biophysica Acta. 34: 103–10. doi:10.1016/0006-3002(59)90237-9. PMID 13804200.
- ^ Kemp, Martin (November 1998). "Visible viruses". Nature. 396 (6707): 123. Bibcode:1998Natur.396..123K. doi:10.1038/24062. PMID 9823890. S2CID 29241274.
- ^ WILDY, P; RUSSELL, WC; HORNE, RW (October 1960). "The morphology of herpes virus". Virology. 12 (2): 204–22. doi:10.1016/0042-6822(60)90195-1. PMID 13785268.
- ^ Lwoff, André; Tournier, Paul (October 1966). "The Classification of Viruses". Annual Review of Microbiology. 20 (1): 45–74. doi:10.1146/annurev.mi.20.100166.000401. PMID 5330240.
- ^ Lwoff, A; Horne, RW; Tournier, P (13 June 1962). "[A virus system]". Comptes rendus hebdomadaires des séances de l'Académie des sciences. 254: 4225–7. PMID 14467544.
- ^ Lwoff, A.; Horne, R.; Tournier, P. (1 January 1962). "A System of Viruses". Cold Spring Harbor Symposia on Quantitative Biology. 27: 51–55. doi:10.1101/sqb.1962.027.001.008. PMID 13931895.
External links edit
- Taking the electron microscope out of the hands of the elite: video interview with Sydney Brenner, describing the development of negative staining